Peral B

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BEC 2020.1 Mitochondrial physiology
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COST Action CA15203 (2016-2021): MitoEAGLE
Evolution-Age-Gender-Lifestyle-Environment: mitochondrial fitness mapping

Peral B

MitoPedia topics: EAGLE 

COST: Member


Name Peral BelΓ©n, Dr.
Institution Institute of Biomedical Research, Alberto Sols (IIBM)

Superior Council of Scientific Investigations (CSIC) and Universidad AutΓ³noma de Madrid (UAM)

Address Arturo Duperier, 4, E-28029
City Madrid
Country Spain
Email [email protected]
O2k-Network Lab



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Peral 2017 Abstract MITOEAGLE Barcelona2017
Adipocyte mitochondrial dysfunction in aging and diabetes: a redox proteomics approach.


My field of research is the human adipose tissue proteome, which I have recently expanded to explore the human adipocyte mitochondrial proteome. My studies are aimed at investigating obesity, obesity-associated diseases and aging....For that reason I think I would fit perfectly in Working Group 3, β€œMitoEAGLE data repository on fat tissues and other tissues” - Peral BelΓ©n 2017.

        • Benefits for COST and for the COST Action MitoEAGLE
Obesity is an outstanding cause of morbidity and mortality in developed countries. Nowadays obesity is a main global health issue not only in view of its enormous social and economic impacts, but also because it predisposes to insulin resistance, type 2 diabetes (T2DM), dyslipidemias, cardiovascular diseases (CVD) and even some types of cancer.
My group is widely experienced in gene and protein expression analysis on adipose tissue, as well in immunolocalization bapproaches. We have conducted a number of proteomics analyses in human adipose tissue (visceral and subcutaneous) in the context of obesity, obesity-associated diseases and aging, tackling in addition the sexual dimorphism of adipose tissue. Two years ago, we started a project to study the differential oxidation of adipocyte mitochondrial proteins, an exciting application of what has been termed Redox Proteomics. This pioneering study has a great potential impact given the role of oxidative stress in obesity, T2DM, CVD and aging.
Over the years we have acquired a strong background on adipose tissue and mitochondrion biology. Thus, we have recently described the human adipocyte mitochondrial proteome and its oxidative modifications associated with aging and type 2 diabetes (TDM2) (GΓ³mez-Serrano, et al., 2017; doi: 10.1016/j.redox.2016.12.013). Our data have provided the most comprehensive representation of the human mitochondrial proteome to date, as well as the first assessment of redox changes in adipocyte mitochondria.
We collaborate with a team of surgeons and endocrine medical doctors from two large and prominent hospitals in Madrid. We also work in close collaboration with the Cardiovascular Proteomics Laboratory of the National Centre for Cardiovascular Research (CNIC) in Madrid.
I am looking forward to meeting you in March at Barcelona in order to share my expertise in mitochondrial function in adipose tissue with all the participants of MitoEAGLE network.

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