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Perfluorooctanoic acid

From Bioblast


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Perfluorooctanoic acid

Description

Perfluorooctanoic acid (PFOA) is a metabolically inert perfluorinated fatty acid which activates UCP1 in brown-fat mitochondria. UCP1-dependent respiration can be stimulated with 600โ€‰ฮผM PFOA after inhibition of the phosphorylation system.

Abbreviation: PFOA

Reference: Shabalina et al (2016) Arch Toxicol






MitoPedia topics: Uncoupler 

Reference

Shabalina IG, Kalinovich AV, Cannon B, Nedergaard J (2016) Metabolically inert perfluorinated fatty acids directly activate uncoupling protein 1 in brown-fat mitochondria. Arch Toxicol 90:1117โ€“28.