Perfluorooctanoic acid (PFOA) is a metabolically inert perfluorinated fatty acid which activates UCP1 in brown-fat mitochondria. UCP1-dependent respiration can be stimulated with 600 μM PFOA after inhibition of the phosphorylation system.
Reference: Shabalina et al (2016) Arch Toxicol
MitoPedia topics: Uncoupler
- Shabalina IG, Kalinovich AV, Cannon B, Nedergaard J (2016) Metabolically inert perfluorinated fatty acids directly activate uncoupling protein 1 in brown-fat mitochondria. Arch Toxicol 90:1117–28.