Prosthetic group

high-resolution terminology - matching measurements at high-resolution

Prosthetic group

Description

A prosthetic group is a cofactor that is attached permanently and tightly or even covalently to an enzyme and that is regenerated in each enzymatic turnover. Thus a prostethic group is distinguished from a coenzyme or cosubstrate that is attached loosely and transiently. Like a coenzyme, the prosthetic group is required by an enzyme for its activity. A prosthetic group is 'a tightly bound, specific nonpolypeptide unit in a protein determining and involved in its biological activity' (IUPAC definition).

FMN/FMNH₂ and FAD/FADH₂ are prosthetic groups of Complex I and Complex II, respectively.

Reference: https://www.ebi.ac.uk/chebi/searchId.do?chebiId=26348

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Substrate

» Substrate

» Product

» Substrates as electron donors

» Cellular substrates

» MitoPedia: Substrates and metabolites

» Substrate-uncoupler-inhibitor titration

Cofactor

» Cofactor

» Coenzyme, cosubstrate

» Nicotinamide adenine dinucleotide

» Coenzyme Q2

» Prosthetic group

» Flavin adenine dinucleotide

Referennces

» Gnaiger E (2023) Complex II ambiguities ― FADH2 in the electron transfer system. MitoFit Preprints 2023.3.v6. https://doi.org/10.26124/mitofit:2023-0003.v6

MitoPedia topics: Enzyme, Substrate and metabolite