Rodriguez 2020 J Gerontol A Biol Sci Med Sci

From Bioblast
Publications in the MiPMap
RodrΓ­guez E, Hakkou M, Hagen TM, Lemieux H, Blier PU (2020) Divergences in the control of mitochondrial respiration are associated with lifespan variation in marine bivalves. J Gerontol A Biol Sci Med Sci 76:796-804.

Β» PMID: 33257932

Rodriguez Enrique, Hakkou Mohammed, Hagen Tory M, Lemieux Helene, Blier Pierre U (2020) J Gerontol A Biol Sci Med Sci

Abstract: The role played by mitochondrial function in the aging process has been a subject of intense debate in the past few decades, as part of the efforts to understand the mechanistic basis of longevity. The mitochondrial oxidative stress theory of aging (MOSTA) suggests that a progressive decay of this organelle's function leads to an exacerbation of oxidative stress, with deleterious impact on mitochondrial structure and DNA, ultimately promoting aging. Among the traits suspected to be associated with longevity is the variation in regulation of oxidative phosphorylation, potentially impacting the management of oxidative stress. Longitudinal studies using the framework of metabolic control analysis have shown age-related differences in flux control of respiration, but this approach has seldom been taken on a comparative scale. Using four species of marine bivalves exhibiting a large range of maximum lifespans (from 28y to 507y), we report lifespan-related differences in flux control at different steps of the electron transfer system. Increased longevity was characterized by a lower control by NADH- (complex I-linked) and Succinate- (complex II- linked) pathways, while respiration was strongly controlled by complex IV when compared to shorter-lived species. Complex III exterted a strong control over respiration in all species. Furthermore, high longevity was associated with higher citrate synthase activity, and lower ATP synthase activity. Relieving the control exerted by the electron entry pathways could be advantageous for reaching a higher longevity, leading to an increased control by complex IV, the final electron acceptor in the electron transfer system. β€’ Keywords: Invertebrate, Longevity, Metabolism, Mitochondria β€’ Bioblast editor: Plangger M β€’ O2k-Network Lab: UK London Lane N, CA Edmonton Lemieux H, CA Rimouski Blier PU

Labels: MiParea: Respiration  Pathology: Aging;senescence 

Organism: Molluscs 

Preparation: Isolated mitochondria 

Regulation: Flux control  Coupling state: LEAK, OXPHOS, ET  Pathway: F, N, S, Gp, CIV, ROX  HRR: Oxygraph-2k 


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