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Sandri 2016 Abstract Mito Xmas Meeting Innsbruck

From Bioblast
Mitochondrial quality control in muscle physiology and ageing.

Link:

Sandri M, Romanello V, Tezze C, Favaro G, Lo Verso F (2016)

Event: Mito Xmas Meeting 2016 Innsbruck AT

The cellular basis of age-related tissue deterioration remains largely obscure. The ability to activate compensatory mechanisms in response to environmental stress is an important factor for survival and maintenance of cellular functions. Autophagy is activated both under short and prolonged stress and is required to clear the cell of dysfunctional organelles and altered proteins. The removal of mitochondria via mitophagy requires an efficient mitochondrial shaping machinery. We report that autophagy and mitochondrial dynamics in muscles declines with ageing and their inhibition correlates with age-dependent muscle loss and weakness. Specific autophagy inhibition in muscle has a major impact on muscle strength, ultimately affecting the lifespan of animals. Inhibition of autophagy also exacerbates aging phenotypes in muscle, such as mitochondrial dysfunction, oxidative stress, and profound weakness. Mitochondrial dysfunction and oxidative stress directly affect acto-myosin interaction and force generation. Inhibition of mitochondrial fission or fusion inhibits or enhances mitophagy, respectively. Both fusion and fission when specifically blocked in muscles shorten life span of animals. Therefore, mitochondrial quality control is critical both for muscle function and when impaired it systemically reverberates to whole organism affecting animal health.


Labels: Pathology: Aging;senescence 


Tissue;cell: Skeletal muscle 




Event: B1, Oral, Review 


Affiliations

Sandri M(1,2), Romanello V(1,2), Tezze C(1,2), Favaro G(1,2), Lo Verso F(1,2)
  1. Dept Biomedical Sciences, Univ Padova, Italy.
  2. Venetian Inst Molecular Medicine, Padova, Italy.