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Carriere 2014 Diabetes
Additional label Lactate  +
Coupling states LEAK  + , ROUTINE  + , ET  +
Has abstract The presence of brown adipose tissue (BAT)
The presence of brown adipose tissue (BAT) in human adults opens attractive perspectives to treat metabolic disorders. Indeed, BAT dissipates energy as heat via uncoupling protein (UCP)1. Brown adipocytes are located in specific deposits or can emerge among white fat through the so-called browning process. Although numerous inducers have been shown to drive this process, no study has investigated whether it could be controlled by specific metabolites. Here, we show that lactate, an important metabolic intermediate, induces browning of murine white adipose cells with expression of functional UCP1. Lactate-induced browning also occurs in human cells and ''in vivo''. Lactate controls Ucp1 expression independently of hypoxia-inducible factor-1α and PPARα pathways but requires active PPARγ signaling. We demonstrate that the lactate effect on Ucp1 is mediated by intracellular redox modifications as a result of lactate transport through monocarboxylate transporters. Further, the ketone body β-hydroxybutyrate, another metabolite that impacts redox state, is also a strong browning inducer. Because this redox-dependent increase in Ucp1 expression promotes an oxidative phenotype with mitochondria, browning appears as an adaptive mechanism to alleviate redox pressure. Our findings open new perspectives for the control of adipose tissue browning and its physiological relevance. © 2014 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.
t for profit, and the work is not altered.  +
Has info [http://www.ncbi.nlm.nih.gov/pubmed/25601284 PMID:25601284]  +
Has title Carrière A, Jeanson Y, Berger-Müller S, An
Carrière A, Jeanson Y, Berger-Müller S, André M, Chenouard V, Arnaud E, Barreau C, Walther R, Galinier A, Wdziekonski B, Villageois P, Louche K, Collas P, Moro C, Dani C, Villarroya F, Casteilla L (2014) Browning of white adipose cells by intermediate metabolites: an adaptive mechanism to alleviate redox pressure. Diabetes 63:3253-65.
viate redox pressure. Diabetes 63:3253-65.  +
Instrument and method Oxygraph-2k  +
Mammal and model Mouse  +
MiP area Respiration  + , Exercise physiology;nutrition;life style  +
Preparation Intact cells  +
Tissue and cell Fat  +
Was published by MiPNetLab FR Toulouse Casteilla L +
Was published in journal Diabetes +
Was published in year 2014  +
Was written by Carriere A + , Jeanson Y + , Berger-Mueller S + , Andre M + , Chenouard V + , Arnaud E + , Barreau C + , Walther R + , Galinier A + , Wdziekonski B + , Villageois P + , Louche K + , Collas P + , Moro C + , Dani C + , Villarroya F + , Casteilla L +
Categories Publications
Modification date
"Modification date" is a predefined property that corresponds to the date of the last modification of a subject and is provided by Semantic MediaWiki.
15:11:49, 9 November 2017  +
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