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Coen 2015 Diabetes
Additional label BMI  + , VO2max  +
Coupling states ET  + , LEAK  + , OXPHOS  +
Diseases Obesity  +
Enzyme Complex II;succinate dehydrogenase  + , Marker enzyme  +
Has abstract Both Roux-en-Y gastric bypass (RYGB) surge
Both Roux-en-Y gastric bypass (RYGB) surgery and exercise can improve insulin sensitivity in individuals with severe obesity. However, the impact of RYGB with or without exercise on skeletal muscle mitochondria, intramyocellular lipids, and insulin sensitivity index (S<sub>I</sub>) is unknown. We conducted a randomized exercise trial in patients (''n'' = 101) who underwent RYGB surgery and completed either a 6-month moderate exercise (EX) or a health education control (CON) intervention. S<sub>I</sub> was determined by intravenous glucose tolerance test. Mitochondrial respiration and intramyocellular triglyceride, sphingolipid, and diacylglycerol content were measured in ''vastus lateralis'' biopsy specimens. We found that EX provided additional improvements in S<sub>I</sub> and that only EX improved cardiorespiratory fitness, mitochondrial respiration and enzyme activities, and cardiolipin profile with no change in mitochondrial content. Muscle triglycerides were reduced in type I fibers in CON, and sphingolipids decreased in both groups, with EX showing a further reduction in a number of ceramide species. In conclusion, exercise superimposed on bariatric surgery-induced weight loss enhances mitochondrial respiration, induces cardiolipin remodeling, reduces specific sphingolipids, and provides additional improvements in insulin sensitivity.
ional improvements in insulin sensitivity.  +
Has info [http://www.ncbi.nlm.nih.gov/pubmed/26293505 PMID: 26293505]  +
Has title Coen PM, Menshikova EV, Distefano G, Zheng
Coen PM, Menshikova EV, Distefano G, Zheng D, Tanner CJ, Standley RA, Helbling NL, Dubis GS, Ritov VB, Xie H, Desimone ME, Smith SR, Stefanovic-Racic M, Toledo FG, Houmard JA, Goodpaster BH (2015) Exercise and weight loss improve muscle mitochondrial respiration, lipid partitioning, and insulin sensitivity after gastric bypass surgery. Diabetes 64:3737-50.
stric bypass surgery. Diabetes 64:3737-50.  +
Instrument and method Oxygraph-2k  +
Mammal and model Human  +
MiP area Exercise physiology;nutrition;life style  + , Patients  + , Respiration  + , mt-Medicine  +
Pathways F  + , N  + , NS  + , Other combinations  +
Preparation Permeabilized tissue  +
Tissue and cell Skeletal muscle  +
Was published by MiPNetLab US FL Orlando Goodpaster BH + , US PA Pittsburgh Goodpaster BH + , US FL Orlando Sparks LM + , US FL Orlando Translational Research Institute + , US NC Greenville Neufer PD +
Was published in journal Diabetes +
Was published in year 2015  +
Was written by Coen PM + , Menshikova EV + , Distefano G + , Zheng D + , Tanner CJ + , Standley RA + , Helbling NL + , Dubis GS + , Ritov VB + , Xie H + , Desimone ME + , Smith SR + , Stefanovic-Racic M + , Toledo FGS + , Houmard JA + , Goodpaster BH +
Categories Publications
Modification date
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15:25:19, 9 November 2017  +
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