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Den Besten 2015 Diabetes
Coupling states LEAK  + , OXPHOS  +
Diseases Obesity  +
Has abstract Short-chain fatty acids (SCFAs) are the ma
Short-chain fatty acids (SCFAs) are the main products of dietary fiber fermentation and are believed to drive the fiber-related prevention of the metabolic syndrome. Here we show that dietary SCFAs induce a peroxisome proliferator-activated receptor (PPAR) γ-dependent switch from lipid synthesis to utilization. Dietary SCFA supplementation prevented and reversed high-fat diet-induced metabolic abnormalities in mice by decreasing PPARγ expression and activity. This increased the expression of mitochondrial uncoupling protein 2 and raised the AMP/ATP ratio, thereby stimulating oxidative metabolism in liver and adipose tissue via AMP-activated protein kinase. The SCFA-induced reduction in body weight and stimulation of insulin sensitivity were absent in mice with adipose-specific disruption of PPARγ. Similarly, SCFA-induced reduction of hepatic steatosis was absent in mice lacking hepatic PPARγ. These results demonstrate that adipose and hepatic PPARγ are critical mediators of the beneficial effects of SCFA on the metabolic syndrome, with clearly distinct and complementary roles. Our findings indicate that SCFAs may be used therapeutically as cheap and selective PPARγ modulators.
y as cheap and selective PPARγ modulators.  +
Has info [ PMID:25695945]  +
Has title den Besten G, Bleeker A, Gerding A, van Eu
den Besten G, Bleeker A, Gerding A, van Eunen K, Havinga R, van Dijk TH, Oosterveer MH, Jonker JW, Groen AK, Reijngoud DJ, Bakker BM (2015) Short-chain fatty acids protect against high-fat diet-induced obesity via a PPARγ-dependent switch from lipogenesis to fat oxidation. Diabetes 64:2398-408.
is to fat oxidation. Diabetes 64:2398-408.  +
Instrument and method Oxygraph-2k  +
Mammal and model Mouse  +
MiP area Respiration  + , Exercise physiology;nutrition;life style  +
Pathways F  +
Preparation Isolated mitochondria  +
Tissue and cell Liver  +
Was published by MiPNetLab NL Groningen Reijngoud RJ +
Was published in journal Diabetes +
Was published in year 2015  +
Was written by Den Besten G + , Bleeker A + , Gerding A + , Van Eunen K + , Havinga R + , Van Dijk TH + , Oosterveer MH + , Jonker JW + , Groen AK + , Reijngoud DJ + , Bakker BM +
Categories Publications
Modification date
"Modification date" is a predefined property that corresponds to the date of the last modification of a subject and is provided by Semantic MediaWiki.
09:04:24, 8 November 2016  +
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