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Gnaiger 2000 Transplant Proc
Has abstract AUTOOXIDATION reactions of highly reduced
AUTOOXIDATION reactions of highly reduced organic compounds are a source of reactive oxygen species that contribute to ischemia/reperfusion injury. Antioxidants such as reduced glutathione (GSH; g-glutamylcysteinylglycine) are added to organ preservation solutions to reduce oxidative stress.<sup>1,2</sup> GSH is unstable, however, in University of Wisconsin (UW) solution in the presence of oxygen.<sup>3</sup> To our knowledge, no reports are available on the stability of GSH in other organ preservation solutions, such as histidine-tryptophan-ketoglutarate (HTK) or Celsior solution. The present study reports for the first time a quantitative comparison of autooxidation of GSH in a variety of established preservation solutions, demonstrating in particular the high stability of GSH in HTK solution.
the high stability of GSH in HTK solution.  +
Has info [http://www.ncbi.nlm.nih.gov/pubmed/10700947 PMID: 10700947]  +
Has title Gnaiger E, Kuznetsov AV, Königsrainer A, Margreiter R (2000) Autooxidation of glutathione in organ preservation solutions. Transplant Proc 32:14.  +
Instrument and method Oxygraph-2k  +
MiP area Pharmacology;toxicology  +
Preparation Oxidase;biochemical oxidation  +
Respiration and regulation Oxygen kinetics  + , pH  + , Substrate  + , Temperature  +
Stress Ischemia-reperfusion  + , Oxidative stress;RONS  +
Was published by MiPNetLab AT Innsbruck Gnaiger E + , AT Innsbruck Oroboros +
Was published in journal Transplant Proc +
Was published in year 2000  +
Was written by Gnaiger E + , Kuznetsov AV + , Koenigsrainer A + , Margreiter R +
Categories Publications
Modification date
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07:49:10, 23 January 2019  +
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