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Hanssen 2015 Diabetes
Additional label 2016-02  +
Coupling states LEAK  + , OXPHOS  + , ET  +
Diseases Obesity  +
Has abstract Recruitment of brown adipose tissue (BAT)
Recruitment of brown adipose tissue (BAT) has emerged as a potential tool to combat obesity and associated metabolic complications. Short-term cold acclimation has been shown to not only enhance BAT presence and activity in lean humans, but also improve skeletal muscle metabolic profile to benefit glucose uptake in type 2 diabetic patients. Here, we examined whether short-term cold acclimation also induced such adaptations in ten metabolically healthy obese male subjects. A 10-day cold acclimation period resulted in increased cold-induced glucose uptake in BAT, as assessed by [18F]FDG-PET/CT scanning. BAT activity was negatively related to age, with a similar trend for body fat%. In addition, cold-induced glucose uptake in BAT was positively related to glucose uptake in visceral WAT, although glucose uptake in visceral and subcutaneous WAT depots was unchanged upon cold acclimation. Cold-induced skeletal muscle glucose uptake tended to increase upon cold acclimation, which was paralleled by increased basal GLUT4 localization in the sarcolemma, as assessed in muscle biopsies. Proximal skin temperature was increased and subjective responses to cold were slightly improved at the end of the acclimation period. These metabolic adaptations to prolonged mild cold exposure may lead to improved glucose metabolism or prevent development of obesity-associated insulin resistance and hyperglycemia.
ated insulin resistance and hyperglycemia.  +
Has info [http://www.ncbi.nlm.nih.gov/pubmed/26718499 PMID: 26718499]  +
Has title Hanssen MJ, van der Lans AA, Brans B, Hoeks J, Jardon KM, Schaart G, Mottaghy FM, Schrauwen P, van Marken Lichtenbelt WD (2015) Short-term cold acclimation recruits brown adipose tissue in obese humans. Diabetes 65:1179-89.  +
Instrument and method Oxygraph-2k  +
Mammal and model Human  +
MiP area Respiration  +
Pathways F  + , N  + , NS  + , Other combinations  +
Preparation Permeabilized tissue  +
Stress Temperature  +
Tissue and cell Skeletal muscle  +
Was published by MiPNetLab NL Maastricht Schrauwen P +
Was published in journal Diabetes +
Was published in year 2015  +
Was written by Hanssen MJ + , Van der Lans AA + , Brans B + , Hoeks J + , Jardon KM + , Schaart G + , Mottaghy FM + , Schrauwen P + , Van Marken Lichtenbelt WD +
Categories Publications
Modification date
"Modification date" is a predefined property that corresponds to the date of the last modification of a subject and is provided by Semantic MediaWiki.
12:31:17, 13 November 2017  +
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