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Jelenik 2014 Diabetes
Coupling states OXPHOS  + , ET  +
Diseases Diabetes  +
Has abstract While insulin resistance is known to under
While insulin resistance is known to underlie type 2 diabetes, its role in the development of type 1 diabetes is gaining increasing interest more recently. In a model of type 1 diabetes, the non-obese diabetic (NOD) mouse, we found that insulin resistance driven by lipid- and glucose-independent mechanisms is already present in liver of pre-diabetic mice. Hepatic insulin resistance is associated with a transient rise in mitochondrial respiration, followed by increased production of lipid peroxides and c-jun N-terminal kinase (JNK) activity. At the onset of diabetes, increased adipose tissue lipolysis promotes myocellular diacylglycerol accumulation. This is paralleled by increased myocellular protein kinase C theta (PKCθ) activity and serum fetuin A levels. Muscle mitochondrial oxidative capacity is unchanged at the onset, but decreases at later stages of diabetes. In conclusion, hepatic and muscle insulin resistance manifest at different stages and involve distinct cellular mechanisms during the development of diabetes in the NOD mouse.
development of diabetes in the NOD mouse.  +
Has info [http://www.ncbi.nlm.nih.gov/pubmed/24917575 PMID: 24917575]  +
Has publicationkeywords DE Duesseldorf Roden M  +
Has title Jelenik T, Séquaris G, Kaul K, Ouwens DM,
Jelenik T, Séquaris G, Kaul K, Ouwens DM, Phielix E, Kotzka J, Knebel B, Weiß J, Reinbeck AL, Janke L, Nowotny P, Partke HJ, Zhang D, Shulman GI, Szendroedi J, Roden M (2014) Tissue-specific differences in the development of insulin resistance in a mouse model for type 1 diabetes. Diabetes 63:3856-67.
for type 1 diabetes. Diabetes 63:3856-67.  +
Instrument and method Oxygraph-2k  +
Mammal and model Mouse  +
MiP area Respiration  +
Pathways N  + , NS  + , ROX  +
Preparation Permeabilized tissue  + , Isolated mitochondria  +
Tissue and cell Skeletal muscle  + , Liver  +
Was published by MiPNetLab DE Duesseldorf Roden M +
Was published in journal Diabetes +
Was published in year 2014  +
Was written by Jelenik T + , Sequaris G + , Kaul K + , Ouwens DM + , Phielix E + , Kotzka J + , Knebel B + , Weiß J + , Reinbeck AL + , Janke L + , Nowotny P + , Partke HJ + , Zhang D + , Shulman GI + , Szendroedi J + , Roden M +
Categories Publications
Modification date
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12:46:12, 13 November 2017  +
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