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Lemieux 2009 JBB
Additional label Review  +
Diseases Cardiovascular  +
Has abstract The heart relies mainly on mitochondrial m
The heart relies mainly on mitochondrial metabolism to provide the energy needed for pumping blood to oxygenate the organs of the body. The study of mitochondrial function in the human heart faces many obstacles and elucidation of the role of mitochondria in cardiac diseases has relied mainly on studies with animal models. Cardiac diseases are the leading cause of mortality worldwide. With the emergence of new therapies to treat and prevent heart disease, some aiming at metabolic modulation, a need for acquiring a better understanding of mitochondrial function in the human heart becomes apparent. Our review is aimed at specific evaluation of the human heart in terms of (1) methods to understand mitochondrial function, with particular emphasis on integrated function, (2) data on the role of mitochondrial dysfunction in cardiovascular disease, and (3) possible applications of this knowledge in the treatment of patients with cardiac disease.
reatment of patients with cardiac disease.  +
Has info [http://www.ncbi.nlm.nih.gov/pubmed/19353253 PMID: 19353253]  +
Has publicationkeywords Electron transport complexes  + , Heart failure  + , Mitochondrial defect  + , Oxidative phosphorylation  + , Permeabilized fibers  +
Has title Lemieux H, Hoppel CL (2009) Mitochondria in the human heart. J. Bioenerg. Biomembr. 41:99-106.  +
Mammal and model Human  +
MiP area Respiration  +
Tissue and cell Heart  +
Was published by MiPNetLab US OH Cleveland Hoppel CL + , CA Edmonton Lemieux H +
Was published in journal J Bioenerg Biomembr +
Was published in year 2009  +
Was written by Lemieux H + , Hoppel CL +
Categories Publications
Modification date
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14:48:38, 27 March 2018  +
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