Starkov 2014 Abstract MiP2014
|Mitochondria as H2O2 buffering system.|
Starkov AA (2014)
For decades, mitochondria have been considered a major intracellular source of reactive oxygen species (ROS). Mitochondrial ROS have been viewed as a negative factor, contributing to the damage of cellular components. More recent data point to a more physiological role of mitochondrial-produced ROS in mitochondria-cell communication and intra- and extracellular signaling .
The eventual unraveling of the complex and powerful mitochondrial ROS detoxication system resulted in a concept that mitochondria are more a sink than a source of ROS [2,3]. However, our research indicates that mitochondria are a ROS buffering system that can maintain the intracellular level of ROS in relation to the metabolic circumstances.
In this presentation, I will briefly summarize the state of knowledge on the sources and regulation of ROS production and scavenging in mitochondria and present experimental data on mitochondrial ROS-buffering properties.
Event: B2, Oral MiP2014
Brain Mind Research Inst, Weill Cornell Medical College Cornell Univ, NY, USA. - [email protected]
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