Succinyl-CoA ligase (SUCLA or SUCLG) is a TCA cycle enzyme converting succinyl-CoA + ADP or (GDP) + Pi to succinate + ATP (GTP). Two different isoforms exsist: SUCLA (EC: 220.127.116.11) is the ATP-forming isoenzyme, SUCLG (EC: 18.104.22.168) is the GTP-forming isoenzyme. Both reactions are reversible. This reaction is attributed to mitochondrial substrate-level phosphorylation, which is considered as an alternative way of ATP synthesis because it is partially independent from the respiratory chain and from the mitochondrial proton motive force.
Abbreviation: SUCLA, SUCLG
MitoPedia topics: Enzyme
Communicated by Komlodi T (2016-11-30)