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MitoCom O2k-Fluorometer Report 2011-2014

Dissemination

Public awareness

Year 3:


Year 2:


Year 1:

  • Houska Preis 2011 - Siegerprojekt:
GEWINNER:INNEN DES HOUSKAPREISES 2012
Standard Artikel
Standard Artikel II
TT Artikel
econova

Overview on internet presentations of K-Regio MitoCom

MitoCom Workshops


Publications K-Regio MitoCom

International peer-reviewed journals

MiPNet Publications



Abstracts: Invited lectures at international conferences

Abstracts: Poster presentations at international conferences


Exhibitions at international conferences

Exhibitions and presentations at regional and national events


International cooperations

Semmelweiss Univ. Budapest, HU

Project meeting with L. Tretter, G. Horvath, A. Nagy, T. Komlodi, V. Laner and E. Gnaiger

Duration: 2014-07-20 to 24

Location: Budapest, Hungary

O2k-Network Lab: HU_Budapest_Tretter_L

Univ. Granada, ES

Carolina Doerrier Velasco was working in the D. Swarovski Research Laboratory between September 19th and December 19th, 2011. The scientific visit aimed at improving her professional skills in the field of high resolution respirometry (HRR) based on her involvement in protocol development of the Network MitoCom Tyrol (www.bioblast/MitoCom).

Zewail City for Science and Technology, ET

Two sudents of Prof. Ali Sameh (O2k-Network Lab: EG Cairo Ali SS) were working for two months at the D. Swarovski Lab and focused on their individual projects, learnig high-resolution respirometry.
see: Oroboros_Laboratories:_visiting_scientists#April_2013

University of Cambdrige, UK

Xtreme Everst 2 - high-altitude research in Nepal


Erich Gnaiger with 3 Oxygraphs at the Everest Base Camp
Verena Laner assisted Andrew Murray in the Kathamandu Laboratory
Dr. Erich Gnaiger and Verena Laner participated at the Xtreme Everest 2 Expedition in Nepal.
Erich Gnaiger (Innsbruck, AT) joined the Xtreme Everest 2 mitochondrial team at Everest Base Camp (5,300 m) where acclimation to high altitude was studied using three O2k (March to May 2013). In Kathmandu (Nepal) at low altitude (1,400 m), Andrew Murray (Cambridge, UK) operated high-resolution respirometry on human musle biopsies with assistance by Verena Laner (Innsbruck, AT).


More infomation: Xtreme Everest 2


Some impressions of the Expedition:


The participants from Innsbruck were supported by the K-Regio project MitoCom Tyrol, D. Swarovski Research Laboratory (Medical University of Innsbruck), and OROBOROS INSTRUMENTS.
The project "Light in the powerhouse of the cell - the O2k-Fluorometer" has been nominated for the Tyrolean Innovation Award! see pdf (in German)
Das Projekt "Licht in die Kraftwerke der Zellen - das O2k-Fluorometer" wurde für den Tiroler Innovationspreis nominiert! siehe pdf


MitoCom Track Record 2014

 WhenWhere
MitoCom20142014-10-16
MitoCom
Innsbruck AT, 2014 Oct 16. MitoCom Tyrol - a success story.
MiPNet19.10 IOC95 Obergurgl2014-09-12
Oroboros Instruments
Obergurgl AT, 2014 Sep 12-16. Oroboros O2k-Workshop on O2k-Fluorometry, IOC95 at MiP2014.
EBEC20142014-07-12
EBEC2014.png
Lisbon PT, 2014 Jul 12-17. 18th European Bioenergetics Conference - EBEC2014
Harrison DK, Fasching M, Fontana-Ayoub M, Gnaiger E (2014) The relationship between cytochrome redox state and oxygen consumption in isolated mouse and beef heart mitochondria during hypoxia. EBEC2014.
Krumschnabel G, Eigentler A, Fasching M, Gnaiger E (2014) Combined high-resolution respirometry and fluorometry. Validation of safranin for determination of mitochondrial membrane potential. EBEC2014.
MiPNet19.09 IOC94 Shanghai CN2014-06-27
O2k-Network
Shanghai CN, 2014 Jun 27-Jul 02. Oroboros O2k-Workshop on HRR and O2k-Fluorometry, IOC94. Oroboros representative in China: »CN Shanghai Zenda.
MiPNet19.08 IOC932014-06-17
Oroboros Instruments
Tampere FI, 2014 Jun 17. Oroboros O2k-Lunch Workshop on HRR and O2k-Fluorometry, IOC93 at EUROMIT2014.
EUROMIT20142014-06-15
Euromit2014.jpg
Tampere FI, 2014 Jun 15-19. International Meeting on Mitochondrial Pathology - EUROMIT 2014.
MiPNet19.07 IOC922014-06-05
Oroboros Instruments
Pittsburgh US, 2014 Jun 04-07. OROBOROS O2k-Lunch Workshop on HRR and O2k-Fluorometry, IOC92 at UMDF2014.
UMDF20142014-06-04
UMDF LOGO.JPG
Pittsburgh US, 2014 Jun 04-07. Mitochondrial Medicine, UMDF2014.
MiPNet19.06 IOC91 Philadelphia US2014-06-02
O2k-Network
Philadelphia US, 2014 Jun 02-03. Oroboros O2k-Workshop on HRR and O2k-Fluorometry, IOC91. O2k-Network Lab »US PA Philadelphia Wallace DC.
MiPNet19.05 IOC90 Bolzano IT2014-05-27
OROBOROS-solo.png
Bolzano IT, 2014 May 27. Applied Workshop - High-resolution respirometry and mitochondrial function under hypoxia: overview, demo experiment and discussion. IOC90 at ISMM2014.
ISMM20142014-05-25
ISMM2014.jpg
Bolzano IT, 2014 May 25-31. World Congress on High Altitude Medicine and Physiology, ISMM2014.
MiPNet19.04 IOC89 La Jolla US2014-05-01
O2k-Network
La Jolla US, 2014 May 01-02. Oroboros O2k-Workshop on HRR and O2k-Fluorometry, IOC89. O2k-Network Lab »US CA La Jolla Felding-Habermann B
EB20142014-04-26San Diego US, 2014 Apr 26-30. Symposium for Experimental Biology, EB2014.
MiPNet19.02 IOC88 Schroecken AT2014-04-07
Oroboros Instruments
Schroecken AT, 2014 Apr 07-12. Oroboros O2k-Workshop on HRR and O2k-Fluorometry, IOC88.
Long Night of Research 20142014-04-04
MitoCom
Innsbruck AT, 2014 Apr 04. OROBOROS at Long Night of Research and Science, CCB.
MiPNet18.16 IOC87 Spitsbergen2014-03-24
O2k-Network
Spitsbergen NO, 2014 Mar 24-27. Oroboros O2k-Workshop on HRR and O2k-Fluorometry: Spitsbergen - Enjoy the Cold, IOC87. MiPNet Lab »NO Trondheim Rognmo O.
MiPNet18.15 IOC862014-01-31
O2k-Network
Mumbay IN, 2014 Jan 31. Oroboros O2k-Workshop on HRR and O2k-Fluorometry, IOC86. »IN Mumbai Kolthur-Seetharam U
MiPNet18.14 IOC852014-01-28
Oroboros Instruments
Mahabaleshwar IN, 2014 Jan 28-30. OROBOROS O2k-Workshop on HRR and O2k-Fluorometry, IOC85 at 38th Mahabaleshwar Seminar. MiPNet Lab »IN Mumbai Kolthur-Seetharam U.
38th Mahabaleshwar Seminar2014-01-27Mahabaleshwar IN, 2014 Jan 27-30. Mitochondria, Metabolism and Energetics: 38th Mahabaleshwar Seminar.
MiPNet18.13 IOC84 Alaska2014-01-04
O2k-Network
Big Lake, Alaska US, 2014 Jan 04-07. Oroboros O2k-Workshop on HRR and Racing dogs at Iditarod, IOC84.  »US OK Stillwater Davis MS


MitoCom Track Record 2013

O2k-Workshop, Bangalore, India, Dec 18 prior SMRM2013

A one-day O2k-Workshop on HRR and Fluorometry was given by Dr. Erich Gnaiger at the SMRM meeting in Bangalore.

O2k-Fluorometry Workshop, Trondheim, Norway, Dec 10-11

Dr. Erich Gnaiger and Verena Laner gave an O2k-Workshop, focused on the Fluorescence LED-2 Module prior the seminar 'Exercise in Medicine', which was organized by CERG of the NTNU University.


O2k-Luncheon Seminar, Seoul, Korea, Nov 05 @ ASMRM2013

Dr. Erich Gnaiger (Medical University of Innsbruck) followed the invitation of Prof. Hong Kyu Lee to give a talk at the ASMRM2013 meeting. Furthermore he took this opportunity to give an O2k-Luncheon Workshop on HRR and Fluorometry.

O2k-Fluorometry Workshop, Schroecken, Austria, Oct 09 - 14

A new concept, integrating the Flurometry-Workshop into the Basic-O2k-Workshop, was celebrated at the 80th O2k-Workshop in Schroecken. Tutors: Dr. Erich Gnaiger, Mona Fontana-Ayoub, Verena Laner and Gerhard Krumschnabel.


O2k-Fluorometry Workshop, Obergurgl, Austria, September 19-23

Prior MiP2013, a O2k-Fluorometry Workshop was given in Obergurgl by Dr. Erich Gnaiger, Dr. Mario Fasching, Mona Fontana-Ayoub and Verena Laner. Hands-on sessions for ~30 participants on 6 O2ks.


O2k-Workshop @ MiPsummer, Copenhagen, DK, August 27-29

  • IOC78 - Tutors: Dr. Erich Gnaiger and Verena Laner

O2k-Luncheon Seminar @ UMDF, Newport Beach, CA, US, June 13


Prof. Gottfried Schatz

Article of the Medical University of Innsbruck

O2k-Workshop, Prague, Austria, May 28 - 29

The workshop is organized by Faculty of Science UK (Doc. M. Kalous and Dr. J. Žurmanová) in cooperation with the Institute of Physiology AVCR (Dr. Z. Drahota and Dr. J. Houštěk) and Medical Faculty UK in Hradec Králové (Prof. Z. Červinková). Dr. Gnaiger was invited on the occasion of We invite you to the occasion of purchasing two new OROBOROS O2k supported bhe the Fund for Universite's Development. The workshop provided an introduction to the Oxygraph-2k and MultiSensor technologies (e.g. the O2k-Fluorescence LED2-Module, which was developped within the K-Regio Project MitoCom Tyrol).

O2k-Workshop, Schroecken, Austria, Apr 09 - 14


O2k-TPP-Workshop, Innsbruck, Austria, Jan 22 - 25


O2k-Workshop, Kolkata, India, January 15 - 16

Dr. Erich Gnaiger - accompanied by Mag. Verena Laner (Oroboros Instruments) - participated at the Neurocon 2013 in Kolkata. Prior the conferece, an O2k-Workshop on high-resolution respirometry and O2k-Fluorometry was held for approx. 30 participants.

MitoCom Track Record 2012

O2k-Workshop, Schroecken, Austria, Dec 5 - 10


Bioblast 2012 - Conference on Mitochondrial Competence

The Bioblast Conference 2012 took place in Hotel Grauer Bär from 10th to 12th December 2012. With more than 70 participants from 19 nations the conference was a great success.

For the article of the Medical University Innsbruck, see: MUI website

More information: Bioblast 2012


Padua Muscle Days, Nov 23 - 25

After the satellite meeting in Vienna on October 17th, Prof. Dr. Gnaiger was invited by Prof. Dr. Ugo Carraro (University of Padua) to Padua for a talk on high-resolution respirometry in permeabilized fibers from small biopsies of human muscle.


MCI Forum Technologie & Life Sciences, Innsbruck, Nov 6

In her talk, Mag. Verena Laner will outline the development of the company OROBOROS INSTRUMENTS and will walk you through the early company days up to the current K-Regio Project MitoCom Tyrol. Programme


Satellite Meeting Vienna, Oct 17

Dr. Erich Gnaiger participated at the Satellite Meeting in Vienna, which took place on 17th October.

Attendees of this meeting were Delegates of the University in Padua (Univ.-Prof. Dr. Ugo Carraro and Dr. Sandra Zampieri), University in Chieti (Univ.-Prof. Dr. Protasi) and University in Rome (Univ.-Prof. Dr. Andrea Musaro).

The meeting was organized by Dr. Kern from the Ludwig Boltzmann Institute in Vienna.


Standort Lunch Vienna, 2012 Sep 27

Dr. Erich Gnaiger presented the MitoCom project at the Standort Lunch in Vienna, organized by the Standortagentur Tirol. More information.

The article of the STANDORT Tirol you can find in issue no. 15, page 8


Medizintechnikforum Hall, 2012 Sep 20 to 21

OROBOROS INSTRUMENTS exhibited at the Medizintechnikforum Hall, showing latest developments in high-resolution respirometry in combination with the O2k-Fluorescence LED2-Module. MitoCom Tyrol was presented together with the Open Innovation project, both supported by the Government of Tyrol.


Tiroltag, Europäisches Forum Alpbach, 2012 Aug 19

Verena Laner, the project manager of MitoCom Tyrol, took part at the Tirolday, which was the "Opening" of the European Congress in Alpbach 2012. The main topic was "The future of sports in the Alps", which is an integral part of the MitoCom project. Additionally to the presentations and the award presentation ceremony for young scientists, there was a podium discussion with well-known experts such as the famous alpinist Reinhard Messner.


MitoCom Cooperation AltitudeOmics 2012, 2012 July 20 to Aug 13

Dr. Erich Gnaiger participated in the AltitudeOmics2012 project in Bolivia and provided the scientists with two O2ks and his expertise. Aim of the study was to investigate the impacts of hypoxia/acclimatization onto molecular mechanisms of the human cells.


Prof. Dr. Fr. Baby Joseph und Prof. Dr. Erich Gnaiger

Visiting scientist: Prof. Dr. Fr. Baby Joseph, July 19

On July 19th, Prof. Dr. Fr. Baby Joseph visited the Oroboros office.

Time schedule of the research visit

Houska Award 2011 - First price for MitoCom Tyrol, April 26

Mitolab O2k-Fluorometry Workshop Madrid, Spain, May 7

>> See also MitoCom_Tyrol - Report 

O2k-Workshop Schröcken, Austria, April 11 to 16

O2k-Workshop Sydney, Australia, April 2 to 4

First O2k-Fluorometry Workshop, Innsbruck, March 15 to 16

Manuscript accepted for publication in PloS One, March 9

  • "Physical fitness and mitochondrial respiratory capacity in horse skeletal muscle" (by Votion DM, Gnaiger E, Lemieux H, Mouithys-Mickalad A, Serteyn D) was accepted for publication in PloS One.
  • From the anonymous referee's comments:
    • Reviewer #1: "This is an original work performed with state of the art methodologies, as high-resolution respirometry. The results indicate that not only mitochondrial capacity is a limiting factor of horse performance but also the modalities of energy substrate utilization. Horse is an animal of choice for energetic studies since it shows a huge consumption of oxygen during muscle contraction, suggesting an positive adaptation of the mitochondrial system as compared to other animals. .. This article provides new findings on the link between mitochondrial capacity and whole animal body size and aerobic capacity. It also clarifies whether mitochondrial capacity is a controling factor for horse performance. An important finding is also that the control by the phosphorylation system is stable and does not vary with the performance of the horse. In contrast, the relative utilization of complex I versus complex II varies witht he performance, and this is a new finding which adds up to our knowledge of energy regulation. This work is of broad interest for sport physiology, metabolic researchers and aging research."
    • Reviewer #2: "The results could be described in a much easier way if utilizing classical definitions of mitochondrial respiratory parameters (from the late Britton Chance's milestones), such as state IV (or II), state III, uncoupled respiration, respiratory control ratio and so on." (Comment: MitoPedia: Respiratory states)


MitoCom track record 2011

2011-11-29: 9. Tiroler Innovationstag

Programm
ab 12.30 Uhr: Treffen im Congress Innsbruck, 3. Stock
13.00 Uhr: Begrüßung DDr. Petra Stöckl (Programm Managerin Life Sciences Tirol)
13.05 Uhr: Die neue Clusterstrategie. Vorstellung der Eckdaten
13.20 Uhr: Vorstellung der Clusterpartner und Diskussion der Clusterstrategie
  • 14.15 Uhr Vorstellung K-Regio MitoCom. Univ.-Prof. Dr. Erich Gnaiger (Oroboros)
15:00 m Tiroler Innovationstag - Programm


2011-11-19: An extension of Bioblast

2011-11-11: Bioblast alert

  • Bioblast alert was launched, for information purposes, not intended to be an advertisement.

2011-11-04: Product news

2011-November: MitoCom Lectures, Innsbruck

2011-10-20 to 21: Targeting Mitochondria, Berlin, DE

  • Invited lecture: Erich Gnaiger - Gnaiger 2011 Abstract-Berlin
  • Exhibition of OROBOROS INSTRUMENTS and MitoCom Tyrol: Katrin Stecher, Lyda Staudacher

2011-09-24: High-output to replace wasteful high-throughput?

2011-09-05 to 04: MiP2011 Bordeaux, France

2011-08-31 to 09-04: KAGOSHIMA JAPAN

2011-08-26 to 27: O2k-Workshop China

2011-08-12: Circular on MitoScore

MitoScore is an initiative of MitoCom:

2011-08-09: Manuscript accepted for publication in IJBCB

  • "Mitochondrial respiratory control and early defects of oxidative phosphorylation in the failing human heart" (by Lemieux H, Semsroth S, Antretter H, Höfer D, Gnaiger E) was accepted for publication in Intl. J. Biochem. Cell Biol.
  • From the anonymous referee's comments:
    • Reviewer #1: "The manuscript by Lemieux and colleagues offers interesting insight into the bioenergetics of early phases of heart failure."
    • Reviewer #2: "This is a beautifully written work, replete with well-designed experiments and, within the space limitations, a nice review of the pertinent literature. The demonstration of impaired mitochondrial fatty acid oxidation in early stages of human failure is very important, as is the demonstration of defects in the phosphorylation system and Complex I-linked respiration."
    • Reviewer #3: "The manuscript belongs literally to the symphony of bioenergetics and have mastered on a maximum thorough and detailed level a priority study of human heart disease bioenergetics in an intermediate state of heart disease, which was done only scarcely in medical sciences and for this orthodox approach this work deserves a high attention. It elegantly describes detailed oxidative phosphorylation parameters in heart disease compared to the control human heart. Using high-resolution respirometry of permeabilized human heart muscle fibres authors progressively describe distinct aspect of measured data in logical steps to present important differences of diminished mitochondrial function during heart failure. Using elegant protocols developed for years, authors distinguish between phosphorylating (OXPHOS) and non-phosphorylating (ETS) conditions with both complex I and II input using physiological substrates of glucose and lipid oxidation. With presented protocols, authors are able to provide conclusions regarding, e.g., complex I impairment, phosphorylation system limitation (3.2) mitochondrial content (3.3), leak respiration involvement, etc., besides OXPHOS and ETS capacities. Authors use their own terminology describing respiratory states. It would be useful to explain briefly their terminology also in terms of the canonical state 2 - 4 terminology. In spite of this, the methodology approach and presented data are well explained."

2011-07-18: Informal MitoCom-MiPArt 18:18

  • Monday, July 18 ● 18:18 h ● Schöpfstr. 18 – we thank our guests for sharing a friendly 18:18 evening with us.
    • Informal get-together at 'Oroboros' - science and art - celebrate a "beautifully written work" - a "symphony of bioenergetics" (see 2011-08-09).
    • Celebrate the official acceptance of K-Regio MitoCom Tyrol.
    • Explore future perspectives.

2011-07-12: The K-Regio MitoCom project - accepted

2011-07-12: Manuscript accepted in AJP

2011-07-11 to 13: Introductory O2k-Workshop (IOC62) - MitoCom Tyrol

  • Location: OROBOROS INSTRUMENTS, Schöpfstr. 18, Innsbruck, Austria.
  • More informatio: IOC62

2011-06-15 to 18: UMDF Mitochondrial Medicine 2011 - Chicago, US

2011-05-18: MiPArt - Mitochondria - the Aliens in our Cells

MiPArt - Mitochondria - the Aliens in our Cells

  • Exhibition (Odra Noel, Richard Altmann and others)
  • Presentation of MitoCom Tyrol

2011-05-01: Start K-Regio Project MitoCom Tyrol

Workshops towards MitoCom 1

» Archive K-Regio MitoCom 1


Management

  • 2011-10-30: ORO installed an 'Intern wiki' for communication, documentation and organization of the K-Regio Project MitoCom.


Minutes and notes

2014-04-23, C. Lass-Flörl

  • Beteiligte: Cornelia Lass-Flörl (HMM), Michael Blatzer (PhD student), Erich Gnaiger (MUI), Verena Laner (ORO)
  • 16. Oktober:
Topic in etwa: "Mitochondrium 2020" - Mito health/disease, new drugs.
alle MitoCom-Konsortialpartner an einen Tisch; Abschlussveranstaltung und Brainstorming für Fortführung/neue Kollaboration;
Moderation Conny oder Dr. Poewe;
max 4 Vorträge, anschließend Round table mit Buffet; speakers: 1 international, Rest: national, e.g. Dominik Pesta > Young Investigator Perspective; Vortrag über Mitos und klinische Bedeutung.
  • Future Collaboration
Interested in future collaboration beyond MitoCom.
1 Oxygraph included in every FWF proposal for a grant.

Platelets und Mitos - some info

  • Mitos leiden unter Platelets
  • Platelets und Pilz: Pilz fährt Stressfaktoren hoch, Pilz kann nicht mehr aushyphen
  • Platelets: Conny Spät, dzt am MCI - kontaktieren?

Low chronic inflammation

  • red. ROS production and red mt-potential, higher metabolism
  • new uncoupler

General

  • Michael Blatzer interessiert an Oxygraph > Einladung, zu uns ins Labor zu kommen

2014-04-18, M. Krismer, ORT

  • Beteiligte: Martin Krismer (ORT), Julian Lair (ORT), Erich Gnaiger (MUI) und Verena Laner (ORO)
  • Interne Besprechung Prof. Gnaiger und Mitarbeiter
  • Festlegung der Tage an welchen Proben angenommen werden können
  • Monatliche Durchsicht der Potentiellen Spender und Markierung der Studienpatienten als solches um eine Verschiebung zu verhindern
  • Einschluss der Knieprothesen-Patienten mit Entnahme aus dem dist. Aspekt des Vast. lat.
  • Prof. Gnaiger vereinbart mit Dr. Lair eine Besprechungstermin.

2014-02-26, M. Burtscher

  • Beteiligte: Martin Burtscher, Erich Gnaiger, Christiane Bauer, Verena Laner (zT auch Marc Philippe - s. MitoLab)

MitoCom und andere Projekte

  • Kurzupdate über Nepal (Xtreme Everest 2, WP2 und Pläne für Oktober 2014)
  • Konsortialvertrag: An Weiterführung interessiert
  • Schlussveranstaltung: am 16. Oktober geplant
  • Update über Ansturm bei Lange Nacht der Forschung
  • Bridge-Projekt: Diabetiker; pre-conditioning hypoxic + dann HIT (high-intensity intervall training) (Blutproben) - zur Einreichung bereit
  • Ludwig-Boltzmann-Institut: Ausschreibung Dominik - wann?
  • IMS Symposium am 17. Oktober

Mobile Lab

  • Mobile Lab: M. Burtscher weiß, dass eine oberösterreichische Firma eine hypobare Kammer gebaut hat - Martins früherer PhD (Michael Angerer, in Stams) hat Kontakt dazu. >> Florian Hoppel mit einbeziehen.
  • Was wären die Anforderungen? Offene Fragen u.a.: Transportkosten Container, Aufstellung 'gebäudepflichtig'?, Sanitärkosten etc.?
  • Einsatzmöglichkeiten: UMDF Roadshow, Skigebiete (mit prominenten Namen): Peter Schröcksnadel (Schnalstaler Gletscher) und Manhart Michael (Skilifte Lech) für Aufstellung von MitoLab.
  • In herkömmlichen Containern ist das Raumklima nicht gut, die Leistungsfähigkeit der darin lebenden/arbeitenden Personen ist eingschränkt, daher:
  • Test auf UniGelände: 1 klassischer Container, 1 Container mit Lehm, 1 Container aus Vollholz (und Lehm) - FFG BigConair Projekt im Laufen; Ansprechperson: [Marc Philippe - PhD Student]; involviert in das Projekt: Holzbox Garber (bereits in Kontakt von Design-in-Tirol Treffen am 5. Februar 2014)

Kühtai

  • Für 2014 oder 2015 großes Symposium bzgl. Höhentraining geplant.
  • Friedl Ludescher (Präsident des Rodelverbandes und in der Bundessportorganisation - Vertretung für Tirol) - interessiert an Höhentraining.
  • Höhenleistungszentrum Kühtai ist Teil des Olympiazentrums.
  • Treffen zwischen M. Burtscher und Mag. A. Brix vereinbaren.

Weitere Projekte

  • Ab 4. März: Kultida (aus Thailand) im Team von evtl. Kooperation mit Lass-Flörl, Grubeck-Löwenstein oder N. Romani



Gespraechsnotiz 2nd MitoCom Workshop

H. Insam berichtet über seine Erfahrungen mit dem K-Regio Projekt BioTreat. Neben einer prinzipiell positiven Beurteilung hebt er hervor, dass er aus heutiger Sicht das Projekt mit weniger Partnern (statt 12) starten würde, sowie als Rechtsform einen Verein oder eine GmbH statt eine Gesellschaft bürgerlichen Rechts wählen würde. Als besondere Vorteile hebt er die nachhaltige Schaffung von neuen Kontakten / Kooperationen sowie die Gründung eines Spinoff Unternehmens hervor.

E. Gnaiger (OROBOROS INSTRUMENTS) hebt die vorhanden Kompetenz an zahlreichen Einzelstandorten in Innsbruck hervor und erläutert die Motivation seitens von OROBOROS INSTRUMENTS, nicht nur mitochondrielle Komptenzzentren an verschiedenen internationalen Standorten auszurüsten sondern ein solches auch in Innsbruck zu schaffen.

Thomas Hugl (Ergopspect) hebt die Bedeutung eines Zentrums, das die verschieden Methoden kombiniert und weiterentwickelt, für das Marketing seiner Firma hervor.

A. Hansel (Ionimed) erläutert, dass Ionimed interessiert ist, die Analyse von VCs (volatile components) mit anderen analytischen Techniken zu kombinieren, eine Abluftanalytik für Sportler aufzubauen und dabei insbesondere in Zusammenarbeit mit der Sportmedizin die tatsächliche Relevanz der gemessenen Parameter (zB NH3) abzuklären.

M. Burtscher (Inst. für Sportwissenschaften) erklärt die derzeitige Tätigkeit seines Instituts im Bereich der Leistungsdiagnostik. Hier sind gute Verfahren zB für cardiovaskuläre Untersuchungen des Gesamtorganismus etabliert, es fehlen aber Methoden um zB den Zustand eines Muskels besser zu beurteilen (mitochondrielle Funktion), sowie die Erfassung weiterer Zusatzparameter, welche die Atemgasanalytik liefern könnte. In diesem Zusammenhang wird zu verschiedenen Zeitpunkten die Akzeptant für analytische Methoden mit unterschiedlichen Graden an Invasivität (Muskelbiopsie, Blutprobe, Atemgasanalyse) diskutiert. Respirometrische Messungen erfordern bis jetzt häufig eine Muskelbiopsie, aber E. Gnaiger verweist auf eine Publikation, die versucht, ähnliche Rückschlüsse aus Thrombozyten (Blutproben) zu gewinnen. M. Burtscher zeigt sich interessiert. Ein Vergleich der Ergebnisse Muskelbiopsie/ Thrombozyten könnte Teil des Projektes sein mit dem Ziel, gleichwertige Information lediglich durch eine Blutprobe zu gewinnen.


Nach der ersten Runde fasst Petra Stöckl (Standortagentur Tirol) zusammen, dass ein Diagnostikzentrum mit Fokus auf Leistungsdiagnostik realistisch erscheint und stellt folgende Fragen:

A: Ist die notwendige Bandbreite an Methoden von den Partnern abgedeckt? Fehlen Methoden (Partner)?

B: Wer kann nun als Zielgrupe „Kunden“ festgeschrieben werden?

M. Burtscher führt bereits existierende Kundengruppen für Leistungsdiagnostik auf: sportmedizinische Praxen (die nicht nur Spitzensportler betreuen!), Zentren für Spitzensportler aber auch Leistungsdiagnostiker, die zB auch im Bereich Fitnessstudios arbeiten.

Als mögliche Ausweitung der Produktpallete / des Kundenkreises erwähnt Rainer Schneider (Inst. Biochemie) diverse Bewegungsstörungen.

O. Galvan und C. Pototschnig (HNO) berichten über den Einsatz von Trainings- und Ernährunsprogrammen bei Tumorpatienten. Alle Methoden, die geeignet erscheinen, den Trainingseffekt zu quantifizieren, bieten sich hier an. Bei solchen Patienten wird manchmal auch ein Gerät zur elektrischen Muskelstimulation der Fa MedEl eingesetzt, was MedEl zu einem potentiellen Partner macht. Der Einsatz von speziellen Nahrungsmitteln zum Konditionsaufbau bei diesen Patienten macht die Herstellerfirmen dieser Nahrungsmittel zu potentiellen Kunden von Wirksamkeitsstudien.

Armin Hansel (Ionimed) möchte den Antrag auf ein Vorzeigeprojekt beschränken, das in 2-3 Jahren auch tatsächlich durchführbar ist. Insbesondere verweist er darauf, dass komplette klinische Studien (für eine Behandlungsmethode, oder eine Nahrungsmittelergänzung) in diesem Rahmen nicht machbar sein. Er plädiert daher für eine starke Fokussierung auf „Sport“. Die Vertreter der HNO stellen jedoch klar, dass keineswegs an komplette klinische Studien gedacht sei, eher an begleitende Analytik bereits angewandter Behandlungsmethoden.

Walther Parson (Gerichtsmedizin) erklärt, dass die Gerichtsmedizin am Aufbau einer mitochondriellen DNA Datenbank arbeitet. Die Qualitätsüberprüfung von mitochondrieller DNA und in Folge die Zuordnung eines Individuums zu einer mitochondriellen Haplogruppe, könnte insbesondere für Sportler (Leistungsdiagnostik) von Interesse sein. W. Parson weist darauf hin, dass es einer großen Stichprobe bedarf, um eine mögliche Korrelation zwischen Haplotypen und Phänotypen nachzuweisen.

E. Gnaiger erklärt, dass das geplante K-Regio Projekt ein Standbein im klinischen Bereich Med.Univ. / TILAK benötigt, auch um die entsprechende Laborkapazität zu haben, eventuell könnte es sich auch um eine mobile Laboreinheit handeln. Es kommen mehrere Partner in Frage, die jedoch heute großteils nicht anwesend sind und noch kontaktiert werden müssen. Von anderen Teilnehmern wird auch darauf hingewiesen, dass eine entsprechende Anbindung auch im Sinne der ärztlichen Betreuung sinnvoll erscheint (die jedoch auch über die Sportmedizin gegeben ist).

In einer Diskussion wird festgehalten, dass der Bedarf für ein „zentrales Labor“ aus der Sicht von Ionimed (A. Hansel) für die Atemgasanalysen nicht, aber aus der Sicht von Oroboros Instruments (M. Fasching) für die respirometrischen Analysen / Probennahme sehr wohl gegeben ist.

P. Stöckl schlägt vor, dass als nächster Schritt eine Kerngruppe von Firmenpartnern weitere Planungsarbeiten übernehmen soll. Unabhängig von den direkten Gesprächen, die nun unmittelbar beginnen sollen, wird ein Treffen am Institut für Sportwissenschaften für den 3. Feb. 2011, 15:30, fixiert.

Gespraechsnotiz 1st MitoCom Workshop

Hintergrund

Das Projekt „MitoCom“ könnte zur Entstehung eines Forschungs- und Diagnostik-Zentrums für Klinische Physiologie und Pathologie der Mitochondrien mit state-of-the-art Ausstattung für bioenergetische Untersuchungen führen. Alle, die an einer Kooperation in diesem Bereich interessiert sind, wurden vorab von Herrn Gnaiger (Oroboros Instruments) als Hauptinitiator mit Unterstützung der TZS zu diesem Impulsgespräch eingeladen. Mit dem heutigen Gespräch sollen Ideen gesammelt werden, wie so ein Kompetenzzentrum ausschauen könnte bzw. welche Kompetenzen aus Sicht der Teilnehmer angeboten werden können.

Ergebnisse

Nach einer kurzen Vorstellungsrunde der einzelnen Teilnehmer und deren Tätigkeitsfelder kristallisieren sich folgende Schwerpunkte für das Angebot eines Kompetenzzentrums heraus:

  • High-Tech Plattform für Messungen (Zertifizierungsstelle)
  • Mitochondriale Diagnostik für Anwendung im Sport/Leistungssport
  • Diagnostik von mitochondrialen Erkrankungen
  • Gesundes Altern (Haut, Muskel, Blutgefäße) – im weiteren Sinne auch bei Tieren (artgerechte Haltung) – Prävention von Erkrankungen
  • Grundlagenforschung bzw. Auftragsforschung (u.a. Krebsforschung,…)

Grundsätzlich sind alle Besprechungsteilnehmer an dieser Projektidee interessiert. Angedacht wäre ein K-Regio (Programmvorstellung durch Rudolf Stoffner) der TZS als erster Schritt. Vor allem der regionale Hintergrund des Kompetenzzentrums sollte im Vordergrund stehen, Internationalisierungsmaßnahmen (EU-Projekte) mit internationalen Partnern sollten erst nach erhöhtem Bekanntheitsgrad und Erfahrungssammlung in Angriff genommen werden.

Weiters ist zu überlegen bei Einreichung eines K-Regios ein klar definiertes Produkt bzw. Dienstleistung mit kommerziellem Hintergrund aufzuzeigen. Eine Idee für ein Endprodukt könnte zB: die örtliche Vernetzung und enge Zusammenarbeit von unterschiedlichen Kompetenzen sein.

Weitere Schritte

Der nächste Call für die Einreichung findet voraussichtlich von Feber bis April 2011 statt. Aus diesem Grund werden die Teilnehmer gebeten für das nächste Treffen am 18.01.2011 konkrete Vorschläge für ein Kernprodukt/-dienstleistung zu sammeln. Auch sollte sich in der nächsten Sitzung das Kernteam (4 bis 5 Partner) herauskristallisieren, welches sich in den darauffolgenden Wochen mit der Antragsstellung befassen wird. Für weitere Fragen zum Projektvorhaben steht Erich Gnaiger, als Hauptinitiator unter [email protected] zur Verfügung.

Call-for-Papers on Sedentary Lifestyle: Causes and Consequences

Dear Dr. Gnaiger,

We have learned of your published research on lifestyles. We would like to invite your participation in our publishing program. In particular, I have in mind a new research or review article for an edited collection (invitation only) being assembled under my overall direction tentatively entitled

Sedentary Lifestyle: Causes and Consequences

The deadline for the abstract is January 10th 2011 and for the completed chapter April 10th 2011.

Proposals to serve as Editor of this volume are welcome up to the abstract deadline. Please send an email to [email protected] including your latest CV.

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We invite you to refer below to an online alternative.

Edited Collection: The contributions for this edited book are intended to range from 4,000-35,000 words (chapters over 10,000 words can be updated by the author for the e-version of their chapter for a period of 2 years at intervals of 6 months, 12 months and 24 months after publication). If you are interested in participating, please consult the Notes for Contributors at the bottom of this letter. Should your schedule not allow a full contribution at this time, we would welcome either a Commentary or Short Communication of 1,000-4,000 words.

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The line-up of chapters is a constantly changing landscape since discussions, commitments and submissions continue on a daily basis right up to and sometimes beyond the close of each volume. 6. Research results (studies) are the primary type of article desired but review articles are also welcome. The Commentary should deal with innovative ideas, developments, directions, misdirections, areas which need to be explored, future outlook, prior errors, problems, personnel, funding, or trends in the field which will be published separately under your name in a section titled Expert Commentary. The deadlines for the abstract for the Commentary and the full Commentary are the same as for regular articles. Please be sure to list the affiliations of the authors. References and figures are permitted without limitation. Short Communications are also subject to the abstract requirement and submission guidelines and deadlines. References and figures are permitted without limitation. 7. 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ONLINE ALTERNATIVE

If the edited collection does not fit your current research profile, we invite you to submit an article for possible online publication in Online Research Updates.

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