Vercesi 2018 Free Radic Biol Med

From Bioblast
Jump to: navigation, search
Publications in the MiPMap
Vercesi AE, Castilho RF, Kowaltowski AJ, Oliveira HC, de Souza-Pinto NC, Figueira TR, Busanello E (2018) Mitochondrial calcium transport and the redox nature of the calcium-induced membrane permeability transition. Free Radic Biol Med 129:1–24.

» PMID: 30172747

Vercesi AE, Castilho RF, Kowaltowski AJ, Oliveira HC, de Souza-Pinto NC, Figueira TR, Busanello E (2018) Free Radic Biol Med

Abstract: Mitochondria possess a Ca2+ transport system composed of separate Ca2+ influx and efflux pathways. Intramitochondrial Ca2+ concentrations regulate oxidative phosphorylation, required for cell function and survival, and mitochondrial redox balance, that participates in a myriad of signaling and damaging pathways. The interaction between Ca2+ accumulation and redox imbalance regulates opening and closing of a highly regulated inner membrane pore, the membrane permeability transition pore (PTP). In this review, we discuss the regulation of the PTP by mitochondrial oxidants, reactive nitrogen species, and the interactions between these species and other PTP inducers. In addition, we discuss the involvement of mitochondrial redox imbalance and PTP in metabolic conditions such as atherogenesis, diabetes, obesity and in mtDNA stability.

Keywords: Calcium, Redox balance, Mitochondrial permeability transition Bioblast editor: Cecatto C O2k-Network Lab: BR_Campinas_Vercesi_AE, BR_Sao_Paulo_Kowaltowski_AJ


Labels: Pathology: Diabetes, Inherited, Obesity  Stress:Permeability transition, Oxidative stress;RONS 





2020-02