Willems 2015 Cell Metab

From Bioblast
Jump to: navigation, search
Publications in the MiPMap
Willems PH, Rossignol R, Dieteren CE, Murphy MP, Koopman WJH (2015) Redox homeostasis and mitochondrial dynamics. Cell Metab 22:207-18.

» PMID: 26166745 Open Access

Willems PH, Rossignol R, Dieteren CE, Murphy MP, Koopman WJH (2015) Cell Metab

Abstract: Within living cells, mitochondria are considered relevant sources of reactive oxygen species (ROS) and are exposed to reactive nitrogen species (RNS). During the last decade, accumulating evidence suggests that mitochondrial (dys)function, ROS/RNS levels, and aberrations in mitochondrial morphology are interconnected, albeit in a cell- and context-dependent manner. Here it is hypothesized that ROS and RNS are involved in the short-term regulation of mitochondrial morphology and function via non-transcriptional pathways. We review the evidence for such a mechanism and propose that it allows homeostatic control of mitochondrial function and morphology by redox signaling.

Copyright © 2015 Elsevier Inc. All rights reserved.


O2k-Network Lab: FR Bordeaux Rossignol R, NL Nijmegen Koopman WJ


Labels:

Stress:Oxidative stress;RONS