Hildebrandt 2008 FEBS J: Difference between revisions
Gnaiger Caro (talk | contribs) No edit summary |
Beno Marija (talk | contribs) No edit summary |
||
Line 12: | Line 12: | ||
{{Labeling | {{Labeling | ||
|area=Respiration, Comparative MiP;environmental MiP | |area=Respiration, Comparative MiP;environmental MiP | ||
| | |injuries=Ischemia-reperfusion | ||
| | |organism=Rat, Annelids | ||
|tissues=Liver | |tissues=Liver | ||
|preparations=Isolated mitochondria | |preparations=Isolated mitochondria | ||
|topics=Inhibitor, Substrate | |topics=Inhibitor, Substrate | ||
|couplingstates=OXPHOS | |couplingstates=OXPHOS |
Revision as of 09:34, 9 November 2016
Hildebrandt TM, Grieshaber MK (2008) Three enzymatic activities catalyze the oxidation of sulfide to thiosulfate in mammalian and invertebrate mitochondria. FEBS J 275:3352-6. |
Hildebrandt TM, Grieshaber MK (2008) FEBS J
Abstract: Hydrogen sulfide is a potent toxin of aerobic respiration, but also has physiological functions as a signalling molecule and as a substrate for ATP production. A mitochondrial pathway catalyzing sulfide oxidation to thiosulfate in three consecutive reactions has been identified in rat liver as well as in the body-wall tissue of the lugworm, Arenicola marina. A membrane-bound sulfide : quinone oxidoreductase converts sulfide to persulfides and transfers the electrons to the ubiquinone pool. Subsequently, a putative sulfur dioxygenase in the mitochondrial matrix oxidizes one persulfide molecule to sulfite, consuming molecular oxygen. The final reaction is catalyzed by a sulfur transferase, which adds a second persulfide from the sulfide : quinone oxidoreductase to sulfite, resulting in the final product thiosulfate. This role in sulfide oxidation is an additional physiological function of the mitochondrial sulfur transferase, rhodanese. โข Keywords: Mitochondria, Sulfide oxidation, Sulfide : quinone oxidoreductase, Sulfur dioxygenase, Sulfur transferase
โข O2k-Network Lab: DE Duesseldorf Grieshaber MK
Labels: MiParea: Respiration, Comparative MiP;environmental MiP
Stress:Ischemia-reperfusion Organism: Rat, Annelids Tissue;cell: Liver Preparation: Isolated mitochondria
Regulation: Inhibitor, Substrate Coupling state: OXPHOS
HRR: Oxygraph-2k
Sulfide