Difference between revisions of "Additive effect of convergent electron flow"
Line 3: | Line 3: | ||
Convergent electron flow simultaneously through CI+II into the [[Q-junction]] supports higher [[OXPHOS capacity]] and [[ETS capacity]] than separate electron flow through either CI or CII.Β Physiological substrate combinations supporting convergent CI+II e-input are required for reconstitution of intracellular [[TCA cycle]] function.Β The convergent CI+II effect may be completely or partially additive, suggesting that conventional bioenergetic protocols with [[mt-preparations]] have underestimated cellular OXPHOS capacities. | Convergent electron flow simultaneously through CI+II into the [[Q-junction]] supports higher [[OXPHOS capacity]] and [[ETS capacity]] than separate electron flow through either CI or CII.Β Physiological substrate combinations supporting convergent CI+II e-input are required for reconstitution of intracellular [[TCA cycle]] function.Β The convergent CI+II effect may be completely or partially additive, suggesting that conventional bioenergetic protocols with [[mt-preparations]] have underestimated cellular OXPHOS capacities. | ||
==References== | ==References== | ||
* | *[[MiPNet12.12]] | ||
* | *[[Gnaiger_2009_IntJBiochemCellBiol]] | ||
{{#set:keyword=Respiration|keyword=Mitochondrial pathways}} | {{#set:keyword=Respiration|keyword=Mitochondrial pathways}} | ||
{{MitoPedia}} | {{MitoPedia}} |
Revision as of 10:50, 20 August 2010
Electron flow converges at the Q-junction from respiratory Complexes I and II (CI+II e-input), glycerophosphate dehydrogenase and electron-transferring flavoprotein. Convergent electron flow corresponds to the operation of the TCA cycle and mitochondrial substrate supply in vivo.
Additive effect
Convergent electron flow simultaneously through CI+II into the Q-junction supports higher OXPHOS capacity and ETS capacity than separate electron flow through either CI or CII. Physiological substrate combinations supporting convergent CI+II e-input are required for reconstitution of intracellular TCA cycle function. The convergent CI+II effect may be completely or partially additive, suggesting that conventional bioenergetic protocols with mt-preparations have underestimated cellular OXPHOS capacities.
References
- high-resolution terminology - matching measurements at high-resolution
Additive effect of convergent electron flow