Difference between revisions of "Additive effect of convergent electron flow"
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|abbr=''A''<sub>''α+β''</sub> | |abbr=''A''<sub>''α+β''</sub> | ||
|description='''Additivity''' describes the princple of substrate control of mitochondrial respiration, where the '''additive effect of convergent CI+II electron flow''' is a consequence of electron flow converging at the '''Q-junction''' from respiratory Complexes I and II ([[CI+II e-input]]). Further additivity may be observed by convergent electron flow through [[glycerophosphate dehydrogenase]] and [[electron-transferring flavoprotein]]. Convergent electron flow corresponds to the operation of the [[TCA cycle]] and mitochondrial substrate supply ''in vivo''. Convergent electron flow simultaneously through C<sub>I+II</sub> into the [[Q-junction]] supports higher [[OXPHOS capacity]] and [[ETS capacity]] than separate electron flow through either CI or CII. Physiological substrate combinations supporting convergent CI+II e-input are required for reconstitution of intracellular [[TCA cycle]] function. The convergent C<sub>I+II</sub> effect may be completely or partially additive, suggesting that conventional bioenergetic protocols with [[Mitochondrial preparations|mt-preparations]] have underestimated cellular OXPHOS capacities, due to the gating effect through a single branch, corresponding to [[additivity]]. | |description='''Additivity''' describes the princple of substrate control of mitochondrial respiration, where the '''additive effect of convergent CI+II electron flow''' is a consequence of electron flow converging at the '''Q-junction''' from respiratory Complexes I and II ([[CI+II e-input]]). Further additivity may be observed by convergent electron flow through [[glycerophosphate dehydrogenase]] and [[electron-transferring flavoprotein]]. Convergent electron flow corresponds to the operation of the [[TCA cycle]] and mitochondrial substrate supply ''in vivo''. Convergent electron flow simultaneously through C<sub>I+II</sub> into the [[Q-junction]] supports higher [[OXPHOS capacity]] and [[ETS capacity]] than separate electron flow through either CI or CII. Physiological substrate combinations supporting convergent CI+II e-input are required for reconstitution of intracellular [[TCA cycle]] function. The convergent C<sub>I+II</sub> effect may be completely or partially additive, suggesting that conventional bioenergetic protocols with [[Mitochondrial preparations|mt-preparations]] have underestimated cellular OXPHOS capacities, due to the gating effect through a single branch, corresponding to [[additivity]]. | ||
|info=[ | |info=[[Gnaiger 2014 MitoPathways]], [[Gnaiger_2009_Int J Biochem Cell Biol]] | ||
|type=Respiration | |type=Respiration | ||
}} | }} | ||
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|mitopedia topic=Substrate and metabolite | |mitopedia topic=Substrate and metabolite | ||
|type=Respiration | |type=Respiration | ||
}} | |||
= List of publications: CI and CII and CI+II = | |||
{{#ask:[[Category:Publications]] [[Substrate states::CI]] [[Substrate states::CII]] [[Substrate states::CI+II]] | |||
|?Was published in year=Year | |||
|?Has title=Reference | |||
|?Mammal and model | |||
|?Tissue and cell | |||
|?Stress | |||
|?Diseases | |||
|format=broadtable | |||
|limit=5000 | |||
|offset=0 | |||
|sort=Was published in year | |||
|order=descending | |||
}} | }} | ||
Revision as of 13:40, 28 July 2014
- high-resolution terminology - matching measurements at high-resolution
Additive effect of convergent electron flow
Description
Additivity describes the princple of substrate control of mitochondrial respiration, where the additive effect of convergent CI+II electron flow is a consequence of electron flow converging at the Q-junction from respiratory Complexes I and II (CI+II e-input). Further additivity may be observed by convergent electron flow through glycerophosphate dehydrogenase and electron-transferring flavoprotein. Convergent electron flow corresponds to the operation of the TCA cycle and mitochondrial substrate supply in vivo. Convergent electron flow simultaneously through CI+II into the Q-junction supports higher OXPHOS capacity and ETS capacity than separate electron flow through either CI or CII. Physiological substrate combinations supporting convergent CI+II e-input are required for reconstitution of intracellular TCA cycle function. The convergent CI+II effect may be completely or partially additive, suggesting that conventional bioenergetic protocols with mt-preparations have underestimated cellular OXPHOS capacities, due to the gating effect through a single branch, corresponding to additivity.
Abbreviation: Aα+β
Reference: Gnaiger 2014 MitoPathways, Gnaiger_2009_Int J Biochem Cell Biol
MitoPedia methods:
Respirometry
MitoPedia topics:
Substrate and metabolite
