Difference between revisions of "Biochemical threshold effect"
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|description=Due to threshold effects, even a large defect diminishing the velocity of an individual enzyme results in only minor changes of pathway flux. | |description=Due to threshold effects, even a large defect diminishing the velocity of an individual enzyme results in only minor changes of pathway flux. | ||
| | |info=[[Gnaiger 2020 BEC MitoPathways]] | ||
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{{ | [[File:NS-threshold.jpg|400px|thumb|Biochemical threshold plot for convergent NS (CI<small>&</small>II-linked; full line, left) and N (CI-linked) pathway flux based on electron gating (dotted line, right). An enzymatic defect of a single step (CIV) exerts no or little effect on N-pathway and NS-pathway flux (horizontal lines) up to a threshold. Beyond the threshold a linear slope is obtained, which is extrapolated to the apparent excess capacity of the single step. The physiological threshold is overestimated for N-pathway flux, which is restricted by electron gating ([[Gnaiger 2020 BEC MitoPathways]].]] | ||
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|mitopedia method=Respirometry | |||
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Latest revision as of 19:45, 1 January 2021
- high-resolution terminology - matching measurements at high-resolution
Biochemical threshold effect
Description
Due to threshold effects, even a large defect diminishing the velocity of an individual enzyme results in only minor changes of pathway flux.
Reference: Gnaiger 2020 BEC MitoPathways
Biochemical threshold plot for convergent NS (CI&II-linked; full line, left) and N (CI-linked) pathway flux based on electron gating (dotted line, right). An enzymatic defect of a single step (CIV) exerts no or little effect on N-pathway and NS-pathway flux (horizontal lines) up to a threshold. Beyond the threshold a linear slope is obtained, which is extrapolated to the apparent excess capacity of the single step. The physiological threshold is overestimated for N-pathway flux, which is restricted by electron gating (Gnaiger 2020 BEC MitoPathways.
MitoPedia methods:
Respirometry
