Difference between revisions of "Chakrabarti 2019 MiP2019"

Latest revision as of 16:39, 1 October 2019

Levels of eicosanoids and cytokines reveal sex differences in cerebellar mitochondria in Parkinson’s disease and controls.

Link: MiP2019

Event: MiP2019

At the request of the author, this abstract is not made available online.

Labels: MiParea: Comparative MiP;environmental MiP, Gender Pathology: Parkinson's

Organism: Human Tissue;cell: Nervous system

Ingram TL(1), Ortori C(2), Shephard F(1), Barrett D(2), Chakrabarti L(1)

Currais A (2015) Ageing and inflammation - A central role for mitochondria in brain health and disease. Ageing Res Rev 21:30–42.
Bose A, Beal MF (2016) Mitochondrial dysfunction in Parkinson’s disease. J Neurochem 139:216-31.
Savica R, Grossardt BR, Bower JH, Ahlskog JE, Rocca WA (2013) Risk factors for Parkinson’s disease may differ in men and women: an exploratory study. Horm Behav 63:308–14.

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 |event=MiP2019
 |abstract=[[Image:MITOEAGLE-logo.jpg|left|100px|link=http://www.mitoglobal.org/index.php/MITOEAGLE|COST Action MitoEAGLE]]
-Ageing is associated with an increase in inflammatory processes[1]. However, it is not clear whether inflammation is a driver, or a consequence of mechanisms of ageing. Parkinson’s disease (PD) occurs more frequently with increased age and is associated with mitochondrial dysfunction and also neuro-inflammation[2]. An under-investigated feature of PD is the sex disparity in disease risk, symptomology, time of onset, and progression[3]. We have obtained absolute quantitation of oxylipins and endocannabinoids, and measured cytokine levels from cerebellar enriched mitochondrial fractions. Mitochondrial fractions from post mortem cerebellar tissue of age-matched male and female patients and controls were surveyed in order to pinpoint pathways that could be targeted to modify disease. Many of the inflammatory species we interrogated were present in significantly different quantities when the sexes were compared. Sex specific disease profiling can lead to the identification of protective factors and also lead to a personalised medicine approach.
+At the request of the author, this abstract is not made available online.
 |editor=[[Plangger M]], [[Tindle-Solomon L]]
 }}