Difference between revisions of "Complex II-linked substrate state"
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|abbr= | |abbr=CII-linked | ||
|description=The '''Complex II-linked substrate state''' is induced in mt-preparations by addition of [[succinate]]+[[rotenone]] (Complex I inhibitor). Succinate is the direct substrate of [[Complex II]] (succinate dehydrogenase). In | |description=The '''Complex II-linked substrate state''' is induced in mt-preparations by addition of [[succinate]]+[[rotenone]] (Complex I inhibitor). Succinate is the direct substrate of [[Complex II]] (succinate dehydrogenase). In CII-linked respiration, only Complex III and Complex IV are involved in pumping protons from the matrix (P-phase) to the N-phase with a ~P/O ratio of 1.75 (P/O<sub>2</sub> = 3.5). | ||
|info=[[Gnaiger 2014 MitoPathways]], [[Gnaiger 2000 Proc Natl Acad Sci U S A]] | |info=[[Gnaiger 2014 MitoPathways]], [[Gnaiger 2000 Proc Natl Acad Sci U S A]] | ||
}} | }} |
Revision as of 13:00, 14 August 2014
- high-resolution terminology - matching measurements at high-resolution
Complex II-linked substrate state
Description
The Complex II-linked substrate state is induced in mt-preparations by addition of succinate+rotenone (Complex I inhibitor). Succinate is the direct substrate of Complex II (succinate dehydrogenase). In CII-linked respiration, only Complex III and Complex IV are involved in pumping protons from the matrix (P-phase) to the N-phase with a ~P/O ratio of 1.75 (P/O2 = 3.5).
Abbreviation: CII-linked
Reference: Gnaiger 2014 MitoPathways, Gnaiger 2000 Proc Natl Acad Sci U S A
MitoPedia topics: "Respiratory state" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property. Respiratory state"Respiratory state" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property., Substrate and metabolite