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Difference between revisions of "Coupling-control efficiency"

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{{MitoPedia
{{MitoPedia
|abbr=''CCC''
|abbr=
|description='''Coupling control capacities''', ''CCC'', are [[flux control capacity|flux control capacities]], ''FCC'', at a constant [[ETS-competent substrate state]]. In mitochondrial preparations, there are three well-defined coupling states of respiration, ''L'', ''P'', ''E'' ([[LEAK]], [[OXPHOS]], [[ETS]]). In intact cells, state ''P'' cannot be induced, but a [[ROUTINE]] state of respiration, ''R'', can be measured.
|description='''Coupling-control efficiencies''' are [[flux control efficiency |flux control efficiencies]] ''j<sub>Z-Y</sub>'' at a constant [[ET-pathway competent state]].
|info=[[Flux control efficiency]]
}}


1. If the [[metabolic control variable]], ''X'', is an [[uncoupler]], the reference state ''Z'' is ''E''. Then two [[background state]]s, ''Y'', of coupling control are possible: The uncoupler may act on the ''L'' or ''P'' state in mt-preparations, and on the ''L'' or ''R'' state in intact cells. The corresponding coupling control capacities are:
== Compare ==
* [[E-L coupling control capacity|''E-L'' coupling control capacity]], Ξ”''j<sub>E-L</sub>'' = (''E-L'')/''E'' = 1-''L/E'' (mt-preparations and intact cells)
::::* [[Coupling-control ratio]]
* [[E-P coupling control capacity|''E-P'' coupling control capacity]], Ξ”''j<sub>E-P</sub>'' = (''E-P'')/''E'' = 1-''P/E'' (mt-preparations)
* [[E-R coupling control capacity|''E-R'' coupling control capacity]], Ξ”''j<sub>E-P</sub>'' = (''E-R'')/''E'' = 1-''R/E'' (intact cells)


2. If the metablic control variable is stimulation by [[ADP]], D, or release of an inhibitor of phosphorylation of ADP to ATP ([[DT-phosphorylation]]; e.g. -Omy), the reference state ''Z'' is ''P'' in mt-preparations at saturating [[[ADP]]], or ''R'' in intact cells at physiologically controlled steady states of [ADP] and ATP-turnover. The background state ''Y'' is ''L'', and the corresponding coupling control capacities are:
{{MitoPedia concepts
* [[P-L coupling control capacity|''P-L'' coupling control capacity]], Ξ”''j<sub>P-L</sub>'' = (''P-L'')/''P'' = 1-''L/P'' (mt-preparations)
|mitopedia concept=Respiratory control ratio
* [[R-L coupling control capacity|''R-L'' coupling control capacity]], Ξ”''j<sub>R-L</sub>'' = (''R-L'')/''R'' = 1-''L/R'' (intact cells)
|info=[[Gnaiger 2013 Abstract MiP2013]]
}}
}}
{{MitoPedia methods
{{MitoPedia methods
|mitopedia method=Respirometry
|mitopedia method=Respirometry
}}
}}
{{MitoPedia topics
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|mitopedia topic=Respiratory control ratio
[[Category:Coupling control]]
}}
== Compare ==
* [[Coupling control ratio]]

Latest revision as of 12:10, 12 November 2020


high-resolution terminology - matching measurements at high-resolution


Coupling-control efficiency

Description

Coupling-control efficiencies are flux control efficiencies jZ-Y at a constant ET-pathway competent state.


Reference: Flux control efficiency


Compare


MitoPedia concepts: Respiratory control ratio 


MitoPedia methods: Respirometry