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Dulac 2020 J Physiol - Revision history
2024-03-28T18:28:51Z
Revision history for this page on the wiki
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Plangger Mario at 12:16, 27 October 2021
2021-10-27T12:16:49Z
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Plangger Mario
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Plangger Mario at 16:26, 6 November 2020
2020-11-06T16:26:51Z
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>|title=Dulac M, Leduc-Gaudet JP, Reynaud O, Ayoub MB, Guérin A, Finkelchtein M, Hussain SN, Gouspillou G (2020) Drp1 knockdown induces severe muscle atrophy and remodelling, mitochondrial dysfunction, autophagy impairment and denervation . J Physiol <del style="font-weight: bold; text-decoration: none;">[Epub ahead of print]</del>.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|title=Dulac M, Leduc-Gaudet JP, Reynaud O, Ayoub MB, Guérin A, Finkelchtein M, Hussain SN, Gouspillou G (2020) Drp1 knockdown induces severe muscle atrophy and remodelling, mitochondrial dysfunction, autophagy impairment and denervation . J Physiol <ins style="font-weight: bold; text-decoration: none;">598:3691-710</ins>.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|info=[https://www.ncbi.nlm.nih.gov/pubmed/32539155 PMID: 32539155]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|info=[https://www.ncbi.nlm.nih.gov/pubmed/32539155 PMID: 32539155]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|authors=Dulac Maude, Leduc-Gaudet Jean-Philippe, Reynaud Olivier, Ayoub Marie-Belle, Guerin Amanda, Finkelchtein Michel, Hussain Sabah Na, Gouspillou Gilles</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|authors=Dulac Maude, Leduc-Gaudet Jean-Philippe, Reynaud Olivier, Ayoub Marie-Belle, Guerin Amanda, Finkelchtein Michel, Hussain Sabah Na, Gouspillou Gilles</div></td></tr>
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Plangger Mario
https://wiki.oroboros.at/index.php?title=Dulac_2020_J_Physiol&diff=204011&oldid=prev
Plangger Mario at 17:27, 22 June 2020
2020-06-22T17:27:18Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 17:27, 22 June 2020</td>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>|area=Respiration, Genetic knockout;overexpression</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|area=Respiration<ins style="font-weight: bold; text-decoration: none;">, mt-Structure;fission;fusion</ins>, Genetic knockout;overexpression</div></td></tr>
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Plangger Mario
https://wiki.oroboros.at/index.php?title=Dulac_2020_J_Physiol&diff=204010&oldid=prev
Plangger Mario: Created page with "{{Publication |title=Dulac M, Leduc-Gaudet JP, Reynaud O, Ayoub MB, Guérin A, Finkelchtein M, Hussain SN, Gouspillou G (2020) Drp1 knockdown induces severe muscle atrophy and..."
2020-06-22T17:21:49Z
<p>Created page with "{{Publication |title=Dulac M, Leduc-Gaudet JP, Reynaud O, Ayoub MB, Guérin A, Finkelchtein M, Hussain SN, Gouspillou G (2020) Drp1 knockdown induces severe muscle atrophy and..."</p>
<p><b>New page</b></p><div>{{Publication<br />
|title=Dulac M, Leduc-Gaudet JP, Reynaud O, Ayoub MB, Guérin A, Finkelchtein M, Hussain SN, Gouspillou G (2020) Drp1 knockdown induces severe muscle atrophy and remodelling, mitochondrial dysfunction, autophagy impairment and denervation . J Physiol [Epub ahead of print].<br />
|info=[https://www.ncbi.nlm.nih.gov/pubmed/32539155 PMID: 32539155]<br />
|authors=Dulac Maude, Leduc-Gaudet Jean-Philippe, Reynaud Olivier, Ayoub Marie-Belle, Guerin Amanda, Finkelchtein Michel, Hussain Sabah Na, Gouspillou Gilles<br />
|year=2020<br />
|journal=J Physiol<br />
|abstract=Mitochondria play central roles in skeletal muscle physiology, including energy supply, regulation of energy-sensitive signalling pathways, reactive oxygen species production/signalling, calcium homeostasis and the regulation of apoptosis. The maintenance of optimal mitochondrial content and function is therefore critical for muscle cells. Mitochondria are now well known as highly dynamic organelles, able to change their morphology through fusion and fission processes. Solid experimental evidence indicates that mitochondrial dynamics play key roles in mitochondrial quality control, and alteration in the expression of proteins regulating mitochondrial dynamics have been reported in many conditions associated with muscle atrophy and wasting. However, the exact role that mitochondrial fission plays in skeletal muscle health remains unclear. To address this issue, we investigated the impact of Drp1 (a protein regulating mitochondrial fission) knockdown, obtained intramuscular injection of Adeno-Associated Virus (AAV) in adult mouse skeletal muscle. Knocking down Drp1 for 4 months resulted in very severe muscle atrophy (40% to 50%). Drp1 knockdown also led to a reduction in ADP-stimulated respiration and increases in markers of muscle regeneration, denervation, fibrosis, oxidative stress and impaired autophagy. Our findings indicate that Drp1 is essential for the maintenance of normal mitochondrial function and that Drp1 suppression severely impairs muscle health. This article is protected by copyright. All rights reserved.<br />
|keywords=Fibrosis, Mitochondrial dynamics, Mitochondrial fission, Myopathic phenotype, Neuromuscular junction, Oxidative stress, Skeletal muscle atrophy<br />
|editor=[[Plangger M]]<br />
}}<br />
{{Labeling<br />
|area=Respiration, Genetic knockout;overexpression<br />
|tissues=Skeletal muscle<br />
|preparations=Permeabilized tissue<br />
|instruments=Oxygraph-2k<br />
|additional=2020-06<br />
}}</div>
Plangger Mario