Dungel 2008 Arch Biochem Biophys

From Bioblast
Revision as of 15:44, 20 March 2015 by Bader Helga (talk | contribs)
(diff) ← Older revision | Latest revision (diff) | Newer revision β†’ (diff)
Publications in the MiPMap
Dungel P, Mittermayr R, Haindl S, Osipov A, Wagner C, Redl H, Kozlov AV (2008) Illumination with blue light reactivates respiratory activity of mitochondria inhibited by nitric oxide, but not by glycerol trinitrate. Arch Biochem Biophys 471:109-15.

Β» PMID: 18230326

Dungel P, Mittermayr R, Haindl S, Osipov A, Wagner C, Redl H, Kozlov AV (2008) Arch Biochem Biophys

Abstract: Nitric oxide (NO) is known to inhibit mitochondrial respiration reversibly. This study aimed at clarifying whether low level illumination at specific wavelengths recovers mitochondrial respiration inhibited by NO and glycerol-trinitrate (GTN), a clinically used NO mimetic. NO fully inhibited respiration of liver mitochondria at concentrations occurring under septic shock. The respiration was completely restored by illumination at the wavelength of 430 nm while longer wavelengths were less effective. GTN inhibited mitochondrial respiration though the efficiency of GTN was lower compared to NO concentrations observed in sepsis models. However, GTN inhibition was absolutely insensitive to illumination regardless of wavelength used. Our data show that visible light of short wavelengths efficiently facilitates the recovery of mitochondria inhibited by NO-gas at the levels generated under septic conditions. The inhibition of mitochondrial respiration by GTN is not sensitive to visible light, suggesting an inhibition mechanism other that NO mediation. β€’ Keywords: Nitric oxide, Mitochondria, Visible light illumination, Glycerol trinitrate

β€’ O2k-Network Lab: AT Vienna Kozlov AV

Labels: MiParea: Respiration 

Stress:Oxidative stress;RONS 

Regulation: Inhibitor  Coupling state: OXPHOS 

HRR: Oxygraph-2k 

Cookies help us deliver our services. By using our services, you agree to our use of cookies.