Difference between revisions of "Dyscoupled respiration"
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Revision as of 14:27, 18 November 2016
- high-resolution terminology - matching measurements at high-resolution
Dyscoupled respiration
Description
Dyscoupled respiration is LEAK respiration distinguished from intrinsically (physiologically) uncoupled and from extrinsic experimentally uncoupled respiration as an indication of extrinsic uncoupling (pathological, toxicological, pharmacological by agents that are not specifically applied to induce uncoupling, but are tested for their potential dyscoupling effect). Dyscoupling indicates a mitochondrial dysfunction.
In addition to intrinsic uncoupling, dyscoupling occurs under pathological and toxicological conditions. Thus a distinction is made between physiological uncoupling and pathologically defective dyscoupling in mitochondrial respiration.
Reference: Gnaiger 2014 MitoPathways
MitoPedia concepts:
Respiratory state
MitoPedia methods:
Respirometry
MitoPedia topics: EAGLE
Coupling efficiency: from 0 to <1
- More details: Uncoupler ♦ ETS coupling efficiency
