Cookies help us deliver our services. By using our services, you agree to our use of cookies. More information

Difference between revisions of "Dyscoupled respiration"

From Bioblast
Line 4: Line 4:
In addition to intrinsic uncoupling, dyscoupling occurs under pathological and toxicological conditions.Β  Thus a distinction is made between physiological uncoupling and pathologically defective dyscoupling in mitochondrial respiration.
In addition to intrinsic uncoupling, dyscoupling occurs under pathological and toxicological conditions.Β  Thus a distinction is made between physiological uncoupling and pathologically defective dyscoupling in mitochondrial respiration.
|info=[[Gnaiger 2014 MitoPathways]]
|info=[[Gnaiger 2014 MitoPathways]]
|type=Respiration
}}
}}
{{MitoPedia concepts
{{MitoPedia concepts
|mitopedia concept=Respiratory state
|mitopedia concept=Respiratory state
|type=Respiration
}}
}}
{{MitoPedia methods
{{MitoPedia methods
|mitopedia method=Respirometry
|mitopedia method=Respirometry
|type=Respiration
}}
}}
{{MitoPedia O2k and high-resolution respirometry|type=Respiration
{{MitoPedia O2k and high-resolution respirometry|type=Respiration
Line 18: Line 15:
{{MitoPedia topics
{{MitoPedia topics
|mitopedia topic=EAGLE
|mitopedia topic=EAGLE
|type=Respiration
}}
}}
Communicated by [[Gnaiger E]] 2010-10-19, edited 2012-10-31.
== Coupling efficiency: from 0 to <1 ==
== Coupling efficiency: from 0 to <1 ==
* ''More details:'' [[Uncoupler]] ♦ [[ETS coupling efficiency]]
* ''More details:'' [[Uncoupler]] ♦ [[ETS coupling efficiency]]

Revision as of 17:12, 18 November 2016


high-resolution terminology - matching measurements at high-resolution


Dyscoupled respiration

Description

Dyscoupled respiration is LEAK respiration distinguished from intrinsically (physiologically) uncoupled and from extrinsic experimentally uncoupled respiration as an indication of extrinsic uncoupling (pathological, toxicological, pharmacological by agents that are not specifically applied to induce uncoupling, but are tested for their potential dyscoupling effect). Dyscoupling indicates a mitochondrial dysfunction.

In addition to intrinsic uncoupling, dyscoupling occurs under pathological and toxicological conditions. Thus a distinction is made between physiological uncoupling and pathologically defective dyscoupling in mitochondrial respiration.


Reference: Gnaiger 2014 MitoPathways


MitoPedia concepts: Respiratory state 


MitoPedia methods: Respirometry 



MitoPedia topics: EAGLE 

Communicated by Gnaiger E 2010-10-19, edited 2012-10-31.

Coupling efficiency: from 0 to <1