Difference between revisions of "Dyscoupled respiration"
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{{MitoPedia | {{MitoPedia | ||
|description=In addition to intrinsic [[uncoupling]], dyscoupling occurs under pathological and toxicological conditions. Thus a distinction is made between physiological uncoupling and pathologically defective dyscoupling in mitochondrial respiration. | |description='''Dyscoupled respiration''' is distinguished from intrinsically (physiologically) [[uncoupled]] and from extrinsic experimentally uncoupled respiration as an indication of extrinsic uncoupling (pathological, toxicological, pharmacological by agents that are not specifically applied to induce uncoupling, but are tested for their potential dyscoupling effect). Dyscoupling indicates a mitochondrial dysfunction. | ||
In addition to intrinsic [[uncoupling]], dyscoupling occurs under pathological and toxicological conditions. Thus a distinction is made between physiological uncoupling and pathologically defective dyscoupling in mitochondrial respiration. | |||
|info=[[Pesta_2010_Protocols]] | |info=[[Pesta_2010_Protocols]] | ||
|type=Respiration | |type=Respiration | ||
}} | }} | ||
{{MitoPedia topics|type=Respiration | {{MitoPedia topics | ||
|mitopedia topic=Respiratory state | |||
|type=Respiration | |||
}} | }} | ||
Revision as of 19:22, 12 November 2011
- high-resolution terminology - matching measurements at high-resolution
Dyscoupled respiration
Description
Dyscoupled respiration is distinguished from intrinsically (physiologically) uncoupled and from extrinsic experimentally uncoupled respiration as an indication of extrinsic uncoupling (pathological, toxicological, pharmacological by agents that are not specifically applied to induce uncoupling, but are tested for their potential dyscoupling effect). Dyscoupling indicates a mitochondrial dysfunction.
In addition to intrinsic uncoupling, dyscoupling occurs under pathological and toxicological conditions. Thus a distinction is made between physiological uncoupling and pathologically defective dyscoupling in mitochondrial respiration.
Reference: Pesta_2010_Protocols
MitoPedia topics: "Respiratory state" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property.
Respiratory state"Respiratory state" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property.
