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Esfandiary 2012 Abstract IOC68 - Revision history
2024-03-28T09:30:10Z
Revision history for this page on the wiki
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Gnaiger Erich at 16:51, 18 July 2014
2014-07-18T16:51:22Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 16:51, 18 July 2014</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|title=Esfandiary A, Pak O, Weissmann N, Sommer N (2012) Mitochondrial respiration in experimental right heart hypertrophy. MiPNet17.08.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|title=Esfandiary A, Pak O, Weissmann N, Sommer N (2012) Mitochondrial respiration in experimental right heart hypertrophy. MiPNet17.08.</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>|info=[[<del style="font-weight: bold; text-decoration: none;">IOC68 Abstracts </del>MiPNet17.08]]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|info=[[MiPNet17.08 <ins style="font-weight: bold; text-decoration: none;">IOC68</ins>]]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|authors=Esfandiary A, Pak O, Weissmann N, Sommer N</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|authors=Esfandiary A, Pak O, Weissmann N, Sommer N</div></td></tr>
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Gnaiger Erich
https://wiki.oroboros.at/index.php?title=Esfandiary_2012_Abstract_IOC68&diff=53725&oldid=prev
Bidaurratzaga Eider: moved Esfandiary MiPNet17.08 to Esfandiary 2012 Abstract IOC68
2013-10-21T07:26:27Z
<p>moved <a href="/index.php/Esfandiary_MiPNet17.08" class="mw-redirect" title="Esfandiary MiPNet17.08">Esfandiary MiPNet17.08</a> to <a href="/index.php/Esfandiary_2012_Abstract_IOC68" title="Esfandiary 2012 Abstract IOC68">Esfandiary 2012 Abstract IOC68</a></p>
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<td colspan="1" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 07:26, 21 October 2013</td>
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Bidaurratzaga Eider
https://wiki.oroboros.at/index.php?title=Esfandiary_2012_Abstract_IOC68&diff=43292&oldid=prev
Meissner Barbara at 09:31, 27 February 2013
2013-02-27T09:31:26Z
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Meissner Barbara
https://wiki.oroboros.at/index.php?title=Esfandiary_2012_Abstract_IOC68&diff=30985&oldid=prev
Meissner Barbara at 11:08, 12 June 2012
2012-06-12T11:08:51Z
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Abstract</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Abstract</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|title=Esfandiary A, Pak O, Weissmann N, Sommer N (2012) Mitochondrial respiration in experimental right heart hypertrophy. MiPNet17.08.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|title=Esfandiary A, Pak O, Weissmann N, Sommer N (2012) Mitochondrial respiration in experimental right heart hypertrophy. MiPNet17.08.</div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">|info=[[IOC68 Abstracts MiPNet17.08]]</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|authors=Esfandiary A, Pak O, Weissmann N, Sommer N</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|authors=Esfandiary A, Pak O, Weissmann N, Sommer N</div></td></tr>
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Meissner Barbara
https://wiki.oroboros.at/index.php?title=Esfandiary_2012_Abstract_IOC68&diff=28050&oldid=prev
Gnaiger Erich at 06:22, 9 April 2012
2012-04-09T06:22:03Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 06:22, 9 April 2012</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|year=2012</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|year=2012</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|event=IOC68</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|event=IOC68</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>|abstract=Right heart failure is the leading cause of death in diseases which induce increased right heart afterload (e.g. pulmonary hypertension). Right heart hypertrophy can compensate for increased afterload, before right heart failure develops. Increased right heart afterload and right heart hypertrophy may induce mitochondrial alterations that determine right heart performance. This study aims to investigate the role of mitochondria in right heart hypertrophy. Right heart hypertrophy was induced in C57Bl6/J wild type mice by pulmonary artery banding (PAB). Control mice received sham surgery. Three weeks later, the development of right heart hypertrophy was evaluated by measurement of right ventricular systolic pressure (RVP) and weight of the right ventricle. Mitochondrial respiration of freshly prepared heart biopsies from the right and left ventricles was quantified by respirometry. We used a substrate-inhibitor protocol with pyruvate, ADP, malate, octanoylcarnitine, rotenone, succinate and antimycin A. PAB caused a significant increase in RVP and right ventricular weight in comparison to sham operated animals. Systolic arterial pressure and the ratio of the weight of the left ventricle to body weight were not significantly changed. We could not detect significant differences in respiration of the right ventricular biopsies after PAB compared to sham operation. Thus, respiration was not altered in the right ventricle during right ventricular hypertrophy induced by PAB. Further studies to evaluate the role of mitochondrial membrane potential, ROS and other metabolic pathways <del style="font-weight: bold; text-decoration: none;">need to be performed</del>.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|abstract=Right heart failure is the leading cause of death in diseases which induce increased right heart afterload (e.g. pulmonary hypertension). Right heart hypertrophy can compensate for increased afterload, before right heart failure develops. Increased right heart afterload and right heart hypertrophy may induce mitochondrial alterations that determine right heart performance. This study aims to investigate the role of mitochondria in right heart hypertrophy. Right heart hypertrophy was induced in C57Bl6/J wild type mice by pulmonary artery banding (PAB). Control mice received sham surgery. Three weeks later, the development of right heart hypertrophy was evaluated by measurement of right ventricular systolic pressure (RVP) and weight of the right ventricle. Mitochondrial respiration of freshly prepared heart biopsies from the right and left ventricles was quantified by <ins style="font-weight: bold; text-decoration: none;">high-resolution </ins>respirometry. We used a substrate-inhibitor protocol with pyruvate, ADP, malate, octanoylcarnitine, rotenone, succinate and antimycin A. PAB caused a significant increase in RVP and right ventricular weight in comparison to sham operated animals. Systolic arterial pressure and the ratio of the weight of the left ventricle to body weight were not significantly changed. We could not detect significant differences in respiration of the right ventricular biopsies after PAB compared to sham operation. Thus, respiration was not altered in the right ventricle during right ventricular hypertrophy induced by PAB. Further studies <ins style="font-weight: bold; text-decoration: none;"> need to be performed </ins>to evaluate the role of mitochondrial membrane potential, ROS and other metabolic pathways.</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>|keywords=Right heart hypertrophy, Right ventricular failure, Cardiac afterload<del style="font-weight: bold; text-decoration: none;">, Pulmonary artery banding</del>, Heart ratio, Mitochondria, Respiration, PAB (<del style="font-weight: bold; text-decoration: none;">Pulmonary Artery Banding</del>), RVP (right ventricular pressure)</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|keywords=Right heart hypertrophy, Right ventricular failure, Cardiac afterload, Heart ratio, Mitochondria, Respiration, PAB (<ins style="font-weight: bold; text-decoration: none;">pulmonary artery banding</ins>), RVP (right ventricular pressure)</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|mipnetlab=DE Giessen Weissmann N</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|mipnetlab=DE Giessen Weissmann N</div></td></tr>
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Gnaiger Erich
https://wiki.oroboros.at/index.php?title=Esfandiary_2012_Abstract_IOC68&diff=28040&oldid=prev
Gnaiger Erich at 11:11, 8 April 2012
2012-04-08T11:11:54Z
<p></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 11:11, 8 April 2012</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Abstract</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Abstract</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>|title=Esfandiary A, Pak O, Weissmann N, Sommer N (2012) Mitochondrial respiration in experimental right heart hypertrophy. MiPNet17.08</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|title=Esfandiary A, Pak O, Weissmann N, Sommer N (2012) Mitochondrial respiration in experimental right heart hypertrophy. MiPNet17.08<ins style="font-weight: bold; text-decoration: none;">.</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|authors=Esfandiary A, Pak O, Weissmann N, Sommer N</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|authors=Esfandiary A, Pak O, Weissmann N, Sommer N</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|year=2012</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|year=2012</div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|organism=Mouse</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|organism=Mouse</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">|tissues=Cardiac Muscle</del></div></td><td colspan="2"></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>}}</div></td></tr>
</table>
Gnaiger Erich
https://wiki.oroboros.at/index.php?title=Esfandiary_2012_Abstract_IOC68&diff=27229&oldid=prev
Meissner Barbara at 14:01, 27 March 2012
2012-03-27T14:01:02Z
<p></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 14:01, 27 March 2012</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Abstract</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Abstract</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>|title=Esfandiary A, Pak O, Weissmann N, Sommer N (2012) Mitochondrial respiration in experimental right heart hypertrophy. <del style="font-weight: bold; text-decoration: none;">IOC68_MiPNet17</del>.08</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|title=Esfandiary A, Pak O, Weissmann N, Sommer N (2012) Mitochondrial respiration in experimental right heart hypertrophy. <ins style="font-weight: bold; text-decoration: none;">MiPNet17</ins>.08</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|authors=Esfandiary A, Pak O, Weissmann N, Sommer N</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|authors=Esfandiary A, Pak O, Weissmann N, Sommer N</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|year=2012</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|year=2012</div></td></tr>
</table>
Meissner Barbara
https://wiki.oroboros.at/index.php?title=Esfandiary_2012_Abstract_IOC68&diff=27223&oldid=prev
Meissner Barbara at 13:59, 27 March 2012
2012-03-27T13:59:43Z
<p></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 13:59, 27 March 2012</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Abstract</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Abstract</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>|title=Esfandiary A, Pak O, Weissmann N, Sommer N (2012) Mitochondrial respiration in experimental right heart hypertrophy. <del style="font-weight: bold; text-decoration: none;">MiPNet IOC68</del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|title=Esfandiary A, Pak O, Weissmann N, Sommer N (2012) Mitochondrial respiration in experimental right heart hypertrophy. <ins style="font-weight: bold; text-decoration: none;">IOC68_MiPNet17.08</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|authors=Esfandiary A, Pak O, Weissmann N, Sommer N</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|authors=Esfandiary A, Pak O, Weissmann N, Sommer N</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|year=2012</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|year=2012</div></td></tr>
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Meissner Barbara
https://wiki.oroboros.at/index.php?title=Esfandiary_2012_Abstract_IOC68&diff=27214&oldid=prev
Meissner Barbara: moved Esfandiary IOC68 to Esfandiary MiPNet17.08
2012-03-27T13:57:24Z
<p>moved <a href="/index.php?title=Esfandiary_IOC68&action=edit&redlink=1" class="new" title="Esfandiary IOC68 (page does not exist)">Esfandiary IOC68</a> to <a href="/index.php/Esfandiary_MiPNet17.08" class="mw-redirect" title="Esfandiary MiPNet17.08">Esfandiary MiPNet17.08</a></p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
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<td colspan="1" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="1" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 13:57, 27 March 2012</td>
</tr><tr><td colspan="2" class="diff-notice" lang="en"><div class="mw-diff-empty">(No difference)</div>
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Meissner Barbara
https://wiki.oroboros.at/index.php?title=Esfandiary_2012_Abstract_IOC68&diff=27061&oldid=prev
Meissner Barbara at 12:29, 26 March 2012
2012-03-26T12:29:55Z
<p></p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 12:29, 26 March 2012</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|abstract=Right heart failure is the leading cause of death in diseases which induce increased right heart afterload (e.g. pulmonary hypertension). Right heart hypertrophy can compensate for increased afterload, before right heart failure develops. Increased right heart afterload and right heart hypertrophy may induce mitochondrial alterations that determine right heart performance. This study aims to investigate the role of mitochondria in right heart hypertrophy. Right heart hypertrophy was induced in C57Bl6/J wild type mice by pulmonary artery banding (PAB). Control mice received sham surgery. Three weeks later, the development of right heart hypertrophy was evaluated by measurement of right ventricular systolic pressure (RVP) and weight of the right ventricle. Mitochondrial respiration of freshly prepared heart biopsies from the right and left ventricles was quantified by respirometry. We used a substrate-inhibitor protocol with pyruvate, ADP, malate, octanoylcarnitine, rotenone, succinate and antimycin A. PAB caused a significant increase in RVP and right ventricular weight in comparison to sham operated animals. Systolic arterial pressure and the ratio of the weight of the left ventricle to body weight were not significantly changed. We could not detect significant differences in respiration of the right ventricular biopsies after PAB compared to sham operation. Thus, respiration was not altered in the right ventricle during right ventricular hypertrophy induced by PAB. Further studies to evaluate the role of mitochondrial membrane potential, ROS and other metabolic pathways need to be performed.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|abstract=Right heart failure is the leading cause of death in diseases which induce increased right heart afterload (e.g. pulmonary hypertension). Right heart hypertrophy can compensate for increased afterload, before right heart failure develops. Increased right heart afterload and right heart hypertrophy may induce mitochondrial alterations that determine right heart performance. This study aims to investigate the role of mitochondria in right heart hypertrophy. Right heart hypertrophy was induced in C57Bl6/J wild type mice by pulmonary artery banding (PAB). Control mice received sham surgery. Three weeks later, the development of right heart hypertrophy was evaluated by measurement of right ventricular systolic pressure (RVP) and weight of the right ventricle. Mitochondrial respiration of freshly prepared heart biopsies from the right and left ventricles was quantified by respirometry. We used a substrate-inhibitor protocol with pyruvate, ADP, malate, octanoylcarnitine, rotenone, succinate and antimycin A. PAB caused a significant increase in RVP and right ventricular weight in comparison to sham operated animals. Systolic arterial pressure and the ratio of the weight of the left ventricle to body weight were not significantly changed. We could not detect significant differences in respiration of the right ventricular biopsies after PAB compared to sham operation. Thus, respiration was not altered in the right ventricle during right ventricular hypertrophy induced by PAB. Further studies to evaluate the role of mitochondrial membrane potential, ROS and other metabolic pathways need to be performed.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|keywords=Right heart hypertrophy, Right ventricular failure, Cardiac afterload, Pulmonary artery banding, Heart ratio, Mitochondria, Respiration, PAB (Pulmonary Artery Banding), RVP (right ventricular pressure)</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|keywords=Right heart hypertrophy, Right ventricular failure, Cardiac afterload, Pulmonary artery banding, Heart ratio, Mitochondria, Respiration, PAB (Pulmonary Artery Banding), RVP (right ventricular pressure)</div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">|mipnetlab=DE Giessen Weissmann N</ins></div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Labeling</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Labeling</div></td></tr>
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Meissner Barbara