Difference between revisions of "Flavin adenine dinucleotide"
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|description='''Flavin adenine dinucleotide''', FAD and FADH<sub>2</sub>, is an oxidation-reduction coenzyme (redox cofactor; compare [[NADH]]). FMN and FAD are the prosthetic groups of flavoproteins (flavin dehydrogenases). [[Electron-transfer-pathway state |Type F substrates]] (fatty acids) generate FADH<sub>2</sub>, the substrate of [[electron transferring flavoprotein]] (CETF). Thus FADH<sub>2</sub> forms a junction or funnel of electron transfer to CETF, the [[F-junction]] (compare [[N-junction]], [[Q-junction]]), in the [[F-pathway control state]]. In contrast, FADH<sub>2</sub> is not the substrate but the product of [[succinate dehydrogenase]] (CII). FAD is the oxidized (quinone) form, which is reduced to FADH<sub>2</sub> (hydroquinone form) by accepting two electrons and two protons. | |description='''Flavin adenine dinucleotide''', FAD and FADH<sub>2</sub>, is an oxidation-reduction coenzyme (redox cofactor; compare [[NADH]]). FMN and FAD are the prosthetic groups of flavoproteins (flavin dehydrogenases). [[Electron-transfer-pathway state |Type F substrates]] (fatty acids) generate FADH<sub>2</sub>, the substrate of [[electron transferring flavoprotein]] (CETF). Thus FADH<sub>2</sub> forms a junction or funnel of electron transfer to CETF, the [[F-junction]] (compare [[N-junction]], [[Q-junction]]), in the [[F-pathway control state]]. In contrast, FADH<sub>2</sub> is not the substrate but the product of [[succinate dehydrogenase]] (CII). FAD is the oxidized (quinone) form, which is reduced to FADH<sub>2</sub> (hydroquinone form) by accepting two electrons and two protons. | ||
}} | }} | ||
== | == FADH<sub>2</sub> and CII == | ||
[[File:Yepez 2018 PLOS One Fig1B.jpg|400px|left|link=Yepez 2018 PLOS One]] | [[File:Yepez 2018 PLOS One Fig1B.jpg|400px|left|link=Yepez 2018 PLOS One]] | ||
* A commonly found error requires correction. For clarification, see page 48 in [[Gnaiger_2020_BEC_MitoPathways |Gnaiger (2020)]] | * A commonly found error requires correction. For clarification, see page 48 in [[Gnaiger_2020_BEC_MitoPathways |Gnaiger (2020)]] |
Revision as of 18:32, 15 May 2021
Description
Flavin adenine dinucleotide, FAD and FADH2, is an oxidation-reduction coenzyme (redox cofactor; compare NADH). FMN and FAD are the prosthetic groups of flavoproteins (flavin dehydrogenases). Type F substrates (fatty acids) generate FADH2, the substrate of electron transferring flavoprotein (CETF). Thus FADH2 forms a junction or funnel of electron transfer to CETF, the F-junction (compare N-junction, Q-junction), in the F-pathway control state. In contrast, FADH2 is not the substrate but the product of succinate dehydrogenase (CII). FAD is the oxidized (quinone) form, which is reduced to FADH2 (hydroquinone form) by accepting two electrons and two protons.
Abbreviation: FAD, FADH2
FADH2 and CII
- A commonly found error requires correction. For clarification, see page 48 in Gnaiger (2020)
MitoPedia topics:
Substrate and metabolite