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| <big><big>''' Functional Mitochondrial Diagnostics '''</big></big>
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| [[File:VASCage logo.png|right|200px|VASCage]]
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| [[File:FFG-logo.png|right|200px|FFG]]
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| __TOC__
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| == Functional Mitochondrial Diagnostics ==
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| ::::* '''Duration''': 4 years
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| ::::* '''Start''': 2023-04-01
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| ::::* '''End''': 2027-03-31
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| == About Functional Mitochondrial Diagnostics ==
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| :::: The Functional Mitochondrial Diagnostics project is a collaboration between VASCage and Oroboros Instruments with the goal to establish in vitro mitochondrial diagnostic standards.
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| :::: The medical community and society in general are becoming increasingly aware of the central role of mitochondria in pharmacology, diseases, and healthy ageing. Functional mitochondrial diagnostics ('bioenergetic snapshots') reflects the evolutionary-genetic background, age, biological sex, lifestyle, and environmental, pharmacological, and toxicological exposure of a person. However, in contrast to genetic mitochondrial screening ('genomic fingerprints'), functional mitochondrial diagnostics has been largely neglected so far in clinical trials. Diagnostic services remain limited and must be established with a focus on quality and affordability for the support of large- and small-scale projects and pilot studies.
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| === Aims ===
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| ::::* Build upon the concept of standardized functional analyses and interpretation of bioenergetic snapshots, which are obtained from substrate-uncoupler-inhibitor titration protocols in bioenergetics assays with PBMCs interrogating specific mitochondrial functions.
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| ::::* Develop a proficiency test to ensure reproducibility.
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| ::::* Establish a Mitochondrial Clinical Center for diagnostics together with VASCage as a service for clinical partners, public interest groups, and stakeholders in the healthcare system.
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| == Coordinator ==
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| ::::* [[Laner V| '''Verena Laner''']] - Oroboros project management
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| == Network ==
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| === Participants ===
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| :::: '''VASCage GmbH''' Research Centre on Vascular Ageing and Stroke - [https://www.vascage.at/ www.vascage.at]
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| :::: '''Oroboros Instruments GmbH''' - [https://www.oroboros.at/ www.oroboros.at]
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| ::::* [[Gnaiger E| '''Erich Gnaiger, Ph.D.''']] - PI
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| ::::* [[Schmitt Sabine| '''Sabine Schmitt, Ph.D''']]
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| ::::* [[Gnaiger C| '''Carolina Gnaiger''']] - Oroboros project management
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| ::::* [[Laner V| '''Verena Laner''']] - Oroboros project management
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| :::: '''Medical University Innsbruck''', Department of Neurology
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| ::::* '''Michael Knoflach'''
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| == Open positions ==
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| ::::* VASCage - PostDoc
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| ::::* VASCage - Technician
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| ::::* VASCage - Quality Manager
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| :::: [https://www.oroboros.at/index.php/about-us/careers/ More information]
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| == Oroboros project involvement ==
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| == Mitochondrial Diagnostics Events ==
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| {{#ask:[[Category:Publications]] [[Additional label::Mitochondrial Diagnostics events]]
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| |?Was published in year=When
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| |?Has title=Where
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| |format=broadtable
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| |limit=5000
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| |offset=0
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| |sort=Was published in year
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| |order=descending
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| }}
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| == Mitochondrial Diagnostics Publications ==
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| {{#ask:[[Additional label::Mitochondrial Diagnostics]]
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| | mainlabel=Link
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| |?Has title=Reference
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| |?Has info=View
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| |?Was published in year=Year
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| |format=broadtable
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| |limit=5000
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| |offset=0
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| |sort=Has title
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| |order=descending
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| }}
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| == Links ==
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| '''News and articles'''
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| :::: [https://tirol.orf.at/stories/3184465/ 18 Millionen für Schlaganfallforschung] tirol.orf.at, online 2022-12-01
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| == Support ==
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| :::: This project has received funding from the Austrian Research Promotion Funding Agency (FFG). [[File:FFG-logo.png|left|100px]]
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