George 2015 Abstract MiPschool Greenville 2015

Mitochondria do not directly oxidize lactate within the cerebral cortex or hippocampus.

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George MAJ, Herbst EAF, Brebner K, Holloway GP, and Kane DA (2015)

Event: MiPschool Greenville 2015

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Affiliations

1-Dept Human Kinetics, St Francis Xavier Univ, Nova Scotia; 2-Dept Human Health Nutritional Sc, Univ Guelph, Ontario; 3-Dept Psychology, St Francis Xavier Univ, Nova Scotia, Canada. - [email protected]

References and acknowledgements

1. Passarella S, Paventi G, Pizzuto R (2014) The mitochondrial L-lactate dehydrogenase affair. Frontiers Neurosc 8:407.
2. Herbst EA, Holloway GP (2015) Permeabilization of brain tissue in situ enables multiregion analysis of mitochondrial function in a single mouse brain. The J Physiology 593:787-801.
3. Jacobs RA, Meinild AK, Nordsborg NB, Lundby C (2013) Lactate oxidation in human skeletal muscle mitochondria. Am Jo Physiol-Endocrin Metabol 304:E686-94.
4. Elustondo PA, White AE, Hughes M, Brebner K, Pavlov E, Kane DA (2013) Physical and functional association of lactate dehydrogenase (LDH) with skeletal muscle mitochondria. J Biolo Chem 288:25309-17.

Supported by: National Science and Engineering Research Council.

• MAJG and EAFH contributed equally to this study.