Difference between revisions of "Glutamate-anaplerotic pathway control state"
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Revision as of 11:24, 8 February 2016
- high-resolution terminology - matching measurements at high-resolution
Glutamate-anaplerotic pathway control state
Description
G: Glutamate as the sole fuel substrate is transported by the electroneutral glutamate-/OH- exchanger, and is oxidised via glutamate dehydrogenase in the mitochondrial matrix.
Abbreviation: G
Reference: Gnaiger 2014 MitoPathways - Chapter 3.3
MitoPedia O2k and high-resolution respirometry: "SUIT state" is not in the list (O2k hardware, DatLab, Oroboros QM, O2k-Open Support, O2k-Respirometry, O2k-FluoRespirometry) of allowed values for the "MitoPedia O2k and high-resolution respirometry" property.
SUIT state"SUIT state" is not in the list (O2k hardware, DatLab, Oroboros QM, O2k-Open Support, O2k-Respirometry, O2k-FluoRespirometry) of allowed values for the "MitoPedia O2k and high-resolution respirometry" property.
G(L)
G(P)
G(E)
Details
In human skeletal muscle mitochondria, OXPHOS capacity with glutamate alone is 50% to 85% of respiration with Glutamate&Malate. Accumulation of fumarate inhibits succinate dehydrogenase and glutamate dehydrogenase. Glutamate derived from hydrolyzation of glutamine is an important aerobic substrate in cultured cells. Mitochondrial glutamate dehydrogenase is particularly active in astrocytes, preventing glutamate induced neurotoxicity. mtNAD-malic enzyme supports an anaplerotic pathway when carbohydrate is limiting.
