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Gnaiger 2023 MiP2023

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Gnaiger 2023 MiP2023

Erich Gnaiger
From globesity to mitObesity.

Link: MiP2023 Obergurgl AT

Gnaiger Erich (2023)

Event: MiP2023 Obergurgl AT

‘Obesity is a complex condition, one with serious social and psychological dimensions, that affects virtually all age and socioeconomic groups and threatens to overwhelm both developed and developing countries’ ― the WHO perspective on ‘globesity’ (https://www.who.int/activities/controlling-the-global-obesity-epidemic). Obesity defined as BMI≥30 (WHO) is biased, overestimating obesity thresholds in taller persons (men) but underestimating it in smaller groups (women) ― a gender data gap. Here obesity is defined as accumulation of excess fat-tissue mass, MFE=MF-MF°. MF° is the fat mass per individual in the healthy reference population at any height and body mass M° without overweight. Body fat excess, BFE=MFE/M°, is related to body mass excess, BME=ME/M°, where ME=M-M°. A balanced BME is BME° = 0.0 with a band width of -0.1 towards underweight and +0.2 towards overweight. The BME is linearly related to the body fat excess in women and men.

mitObesity

Aerobic spiroergometric capacity per body mass VO2max/M and mitochondrial respiratory capacity per muscle mass [1] decline as a function of BME. Compromised mitochondrial fitness across metabolically active organs provides a functional connection between obesity and comorbidities bound to redox imbalance, inflammation, oxidative stress, and insulin resistance: diabetes, cardiovascular and neurodegenerative diseases, various types of cancer (Figure 1). mitObesity is the leading cause of deaths and early aging, prevented by improved quality of life in active lifestyles with exercise and caloric balance.

Obesity has reached the general news, without connection to mitochondria. How do we get from globesity to mitObesity to forge scientific results into knowledge impacting society, health system stakeholders, and politics?

Keywords: obesity, healthy reference population, body mass excess, body mass index, mitochondrial fitness, degenerative diseases


Labels: MiParea: Respiration, Exercise physiology;nutrition;life style, mt-Medicine, mt-Awareness  Pathology: Obesity 

Organism: Human  Tissue;cell: Skeletal muscle 


Coupling state: OXPHOS 


Event: Oral 


Affiliations

Gnaiger E
Oroboros Instruments, Innsbruck, Austria - [email protected]

Reference

  1. Gnaiger E (2009) Capacity of oxidative phosphorylation in human skeletal muscle. New perspectives of mitochondrial physiology. https://doi.org/10.1016/j.biocel.2009.03.013