The printable version is no longer supported and may have rendering errors. Please update your browser bookmarks and please use the default browser print function instead.
News and Events | Working Groups | Short-Term Scientific Missions | Management Committee | Members |
COST Action CA15203 (2016-2021): MitoEAGLE
Evolution-Age-Gender-Lifestyle-Environment: mitochondrial fitness mapping
Gonzalez-Franquesa Alba
MitoPedia topics: EAGLE
COST: ECI COST WG1: WG1 COST WG2: WG2
Name | Gonzalez-Franquesa Alba, Postdoctoral Research Fellow |
---|---|
Institution | The Novo Nordisk Center for Basic Metabolic Research,
Section for Integrative Physiology, KĂžbenhavns Universitet, DK |
Address | Blegdamsvej 3B, 7.7, 2200 |
City | Copenhagen |
State/Province | |
Country | Denmark |
[email protected] | |
Weblink | |
O2k-Network Lab | ES Barcelona Garcia-Roves PM |
Labels:
Publications
Published | Reference | |
---|---|---|
Chicco 2022 MitoFit | 2022 | Chicco AJ, Zilhaver PT, Whitcomb LA, Fresa KJ, Izon CS, Gonzalez-Franquesa A, Izon CS, Dometita C, Irving BA, Garcia-Roves PM (2022) Resolving the Rotenone Paradox: elucidating the complexity of multi-substrate respirometry protocols. https://doi.org/10.26124/mitofit:2022-0017 |
Gonzalez-Franquesa 2022 Redox Biol | 2022 | Gonzalez-Franquesa A, Gama-Perez P, Kulis M, Szczepanowska K, Dahdah N, Moreno-Gomez S, Latorre-Pellicer A, FernĂĄndez-Ruiz R, Aguilar-Mogas A, Hoffman A, Monelli E, Samino S, MirĂł-Blanch J, Oemer G, Duran X, Sanchez-Rebordelo E, Schneeberger M, Obach M, Montane J, Castellano G, Chapaprieta V, Sun W, Navarro L, Prieto I, Castaño C, Novials A, Gomis R, Monsalve M, Claret M, Graupera M, Soria G, Wolfrum C, Vendrell J, FernĂĄndez-Veledo S, EnrĂquez JA, Carracedo A, Perales JC, Nogueiras R, Herrero L, Trifunovic A, Keller MA, Yanes O, Sales-Pardo M, GuimerĂ R, BlĂŒher M, MartĂn-Subero JI, Garcia-Roves PM (2022) Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue. https://doi.org/10.1016/j.redox.2022.102353 |
MitoEAGLE muscle 1 | 2020 | Doerrier C, Gama-Perez P, Distefano G, Pesta D, Soendergaard SD, Chroeis KM, Gonzalez-Franquesa A, Goodpaster BH, Coen P, Larsen S, Gnaiger E, Garcia-Roves PM (2020) Inter-laboratory harmonization of respiratory protocols in permeabilized human muscle fibers. - Updated: 2020-03-08 |
BEC 2020.1 doi10.26124bec2020-0001.v1 | 2020 | Gnaiger E et al â MitoEAGLE Task Group (2020) Mitochondrial physiology. Bioenerg Commun 2020.1. https://doi.org/10.26124/bec:2020-0001.v1 |
Doerrier 2019 MitoFit Preprint Arch EA | 2019 | Doerrier C, Gama-Perez P, Distefano G, Pesta D, Soendergaard SD, Chroeis KM, Gonzalez-Franquesa A, Goodpaster BH, Coen P, Larsen S, Gnaiger E, Garcia-Roves PM (2019) Inter-laboratory harmonization of respiratory protocols in permeabilized human muscle fibers. https://doi.org/10.26124/mitofit:ea19.MiPSchool.0009 |
Pardo 2018 FASEB J | 2018 | Pardo R, VilĂ M, Cervela L, de Marco M, Gama-PĂ©rez P, GonzĂĄlez-Franquesa A, Statuto L, Vilallonga R, SimĂł R, Garcia-Roves PM, Villena JA (2018) Calorie restriction prevents diet-induced insulin resistance independently of PGC-1-driven mitochondrial biogenesis in white adipose tissue. FASEB J 33:2343-58. |
Ejaz 2016 Diabetes | 2016 | Ejaz A, Martinez-Guino L, Goldfine AB, Ribas-Aulinas F, De Nigris V, RibĂł S, Gonzalez-Franquesa A, Garcia-Roves PM, Li E, Dreyfuss JM, Gall W, Kim JK, Bottiglieri T, Villarroya F, Gerszten RE, Patti ME, Lerin C (2016) Dietary betaine supplementation increases Fgf21 levels to improve glucose homeostasis and reduce hepatic lipid accumulation in mice. Diabetes 65:902-12. |
Torres 2016 Redox Biol | 2016 | Torres S, MatĂas N, Baulies A, Nuñez S, Alarcon-Vila C, Martinez L, Nuño N, Fernandez A, Caballeria J, Levade T, Gonzalez-Franquesa A, Garcia-RovĂ©s P, Balboa E, Zanlungo S, FabrĂas G, Casas J, Enrich C, Garcia-Ruiz C, FernĂĄndez-Checa JC (2016) Mitochondrial GSH replenishment as a potential therapeutic approach for Niemann Pick type C disease. Redox Biol 11:60-72. |
Errea 2015 J Neuroinflammation | 2015 | Errea O, Moreno B, Gonzalez-Franquesa A, Garcia-Roves PM, Villoslada P (2015) The disruption of mitochondrial axonal transport is an early event in neuroinflammation. J Neuroinflammation 12:152. |
Schneeberger 2013 Cell | 2013 | Schneeberger M, Dietrich MO, SebastiĂĄn D, ImbernĂłn M, Castaño C, Garcia A, Esteban Y, Gonzalez-Franquesa A, RodrĂguez IC, Bortolozzi A, Garcia-Roves PM, Gomis R, Nogueiras R, Horvath TL, Zorzano A, Claret M (2013) Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance. Cell 155:172-87. |
Abstracts
Published | Reference | |
---|---|---|
Chicco 2022 Abstract Bioblast | 2022 | 4.2. «10+5» Chicco Adam, Zilhaver PT, Whitcomb LA, Fresa KJ, Izon CS, Gonzalez-Franquesa A, Izon CS, Dometita C, Irving BA, Garcia-Roves PM (2022) Elucidating the complexity of substrate-uncoupler-inhibitor titration protocols. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001 »MitoFit Preprint« |
Doerrier 2020 PaduaMuscleDays Poster | 2020 | Doerrier C, Gama-Perez P, Chabi B, Ost M, Distefano G, Pesta D, Dahdah N, Lemieux H, Holody C, Carpenter RG, Tepp K, Puurand M, Kaambre T, Dubouchaud H, Cortade F, Calabria E, Casado M, Fernandez-Ortiz M, Acuna-Castroviejo D, Villena JA, Grefte S, Keijer J, O'Brien K, Sowton A, Murray AJ, Campbell MD, Marcinek DJ, Nollet E, Wuest R, Dayanidhi S, Soendergaard SD, Chroeis KM, Gonzalez-Franquesa A, Goodpaster BH, Coen PM, Larsen S, Gnaiger E, Garcia-Roves PM (2020) Commitment to reproducibility in mitochondrial respiration studies with permeabilized muscle fibers. PaduaMuscleDays. |
Doerrier 2019 MiP2019 | 2019 | Inter-laboratory harmonization of respiratory protocols in permeabilized human muscle fibers. |
Dahdah 2019 MiP2019 | 2019 | Approaches to assess mitochondrial respiration in white adipose tissue. |
Doerrier 2018 MiP2018c | 2018 | Inter-laboratory study on human permeabilized myofibers: effects of fiber preparation, respiration buffer, and blebbistatin on mitochondrial respiratory capacity and oxygen limitation. |
Villena 2017 MiP2017 | 2017 | PGC-1 co-activators mediate calorie restriction-induced mitochondrial biogenesis in white adipose tissue: implications on glucose homeostasis. |
Garcia-Roves 2016a Abstract MitoFit Science Camp 2016 | 2016 | Design and implementation of systems biology approaches to integrate heterogenic data in biomedical research. |
Garcia-Roves 2016b Abstract MitoFit Science Camp 2016 | 2016 | Technical perspective of high-resolution respirometry in permeabilized skinned muscle fibers from different mouse models. |
Garcia-Roves 2013 Abstract MiP2013 | 2013 | Garcia-Roves PM, Gonzalez-Franquesa A, Martinez-Navarro L, Fernandez-Ruiz R (2013) Metabolic flexibility before and after lifestyle intervention in a diet-induced type 2 diabetes animal model. Mitochondr Physiol Network 18.08. |
MitoEAGLE Short-Term Scientific Mission
- Work Plan summary
- Aim and motivation
- A collaboration already exist between the two partners involved in this STSM. This collaboration includes two main projects: the study of mitochondrial function in white adipose tissue (WAT) in order to understand its role and importance in the hallmark of type 2 diabetes; and the implication of both parts in the WG2 and WG3.
- Proposed contribution
- This STSM will be a first step into the assessment of most used protocol for the study of mitochondrial respiration in white adipose tissue preparations (not isolated mitochondria), given the lack of standardized protocols comparisons and the aims of the COST Action.
- Techniques
- Oroboros O2k will be used for measuring mitochondrial respiration in different type of white adipose tissue sample preparation (e.g. whole WAT homogenate, adipocyte after SVF removal, and permeabilized WAT depot after gentle centrifugation to remove lipid layer)
- Planning
- 1 day for study design and clarifying all the variables involved for a proper experimental performance
- 4 days for experimental performance
- 1 day for data analysis
- 4 days for data discussion, along with WG2 and WG3 results discussion
Participated at
- Mitochondrial dysfunction in insulin-dependent tissues such as liver, skeletal muscle and adipose tissue