Huetter 2002 Mol Biol Rep: Difference between revisions
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{{Publication | {{Publication | ||
|title=Hütter E, Renner K, Jansen-Dürr P, Gnaiger E (2002) Biphasic oxygen kinetics of cellular respiration and linear oxygen dependence of antimycin A inhibited oxygen consumption. Molec. Biol. Rep. 29: 83-87. | |title=Hütter E, Renner K, Jansen-Dürr P, Gnaiger E (2002) Biphasic oxygen kinetics of cellular respiration and linear oxygen dependence of antimycin A inhibited oxygen consumption. Molec. Biol. Rep. 29: 83-87. | ||
|info=[http://www.ncbi.nlm.nih.gov/pubmed/12241081 PMID: 12241081] | |||
|authors=Huetter E, Renner K, Jansen-Duerr P, Gnaiger E | |authors=Huetter E, Renner K, Jansen-Duerr P, Gnaiger E | ||
|year=2002 | |year=2002 | ||
|journal=Molec. Biol. Rep. | |journal=Molec. Biol. Rep. | ||
|mipnetlab=AT_Innsbruck_GnaigerE | |mipnetlab=AT_Innsbruck_GnaigerE, AT Innsbruck JansenDuerrP | ||
|abstract=Oxygen kinetics in fibroblasts was biphasic. This was quantitatively explained by a major mitochondrial hyperbolic component in the low-oxygen range and a linear increase of rotenone- and antimycin A- inhibited oxygen consumption in the high-oxygen range. This suggest an i9ncreased production of reactive oxygen species and oxidative stress at elevated, air-level oxygen concentrations. The high oxygen activity of mitochondrial respiration provides the basis for the maintenance of a high aerobic scope at physiological low-oxygen levels, whereas further pronounced depression induces energetic stress under hypoxia. | |abstract=Oxygen kinetics in fibroblasts was biphasic. This was quantitatively explained by a major mitochondrial hyperbolic component in the low-oxygen range and a linear increase of rotenone- and antimycin A- inhibited oxygen consumption in the high-oxygen range. This suggest an i9ncreased production of reactive oxygen species and oxidative stress at elevated, air-level oxygen concentrations. The high oxygen activity of mitochondrial respiration provides the basis for the maintenance of a high aerobic scope at physiological low-oxygen levels, whereas further pronounced depression induces energetic stress under hypoxia. | ||
}} | }} | ||
{{Labeling | {{Labeling | ||
|discipline=Mitochondrial Physiology | |discipline=Mitochondrial Physiology | ||
|injuries=Hypoxia | |||
|organism=Human | |organism=Human | ||
|tissues=Fibroblast | |tissues=Fibroblast | ||
|preparations=Intact Cell; Cultured; Primary | |preparations=Intact Cell; Cultured; Primary | ||
|kinetics=Oxygen | |kinetics=Oxygen | ||
|topics=Respiration; OXPHOS; ETS Capacity | |topics=Respiration; OXPHOS; ETS Capacity | ||
|instruments=Oxygraph-2k | |||
}} | }} | ||
Revision as of 14:02, 10 November 2010
| Hütter E, Renner K, Jansen-Dürr P, Gnaiger E (2002) Biphasic oxygen kinetics of cellular respiration and linear oxygen dependence of antimycin A inhibited oxygen consumption. Molec. Biol. Rep. 29: 83-87. |
Huetter E, Renner K, Jansen-Duerr P, Gnaiger E (2002) Molec. Biol. Rep.
Abstract: Oxygen kinetics in fibroblasts was biphasic. This was quantitatively explained by a major mitochondrial hyperbolic component in the low-oxygen range and a linear increase of rotenone- and antimycin A- inhibited oxygen consumption in the high-oxygen range. This suggest an i9ncreased production of reactive oxygen species and oxidative stress at elevated, air-level oxygen concentrations. The high oxygen activity of mitochondrial respiration provides the basis for the maintenance of a high aerobic scope at physiological low-oxygen levels, whereas further pronounced depression induces energetic stress under hypoxia.
• O2k-Network Lab: AT_Innsbruck_GnaigerE, AT Innsbruck JansenDuerrP
Labels:
Stress:Hypoxia Organism: Human Tissue;cell: Fibroblast Preparation: Intact Cell; Cultured; Primary"Intact Cell; Cultured; Primary" is not in the list (Intact organism, Intact organ, Permeabilized cells, Permeabilized tissue, Homogenate, Isolated mitochondria, SMP, Chloroplasts, Enzyme, Oxidase;biochemical oxidation, ...) of allowed values for the "Preparation" property.
Regulation: Respiration; OXPHOS; ETS Capacity"Respiration; OXPHOS; ETS Capacity" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property.
HRR: Oxygraph-2k
