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Juhasz 2017 MiPschool Obergurgl - Revision history
2024-03-29T08:03:18Z
Revision history for this page on the wiki
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Kandolf Georg at 11:33, 28 March 2018
2018-03-28T11:33:15Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 11:33, 28 March 2018</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>::::#Duan Y, Gross RA, Sheu SS (2007) Ca<sup>2+</sup>-dependent generation of mitochondrial reactive oxygen species serves as a signal for poly(ADP-ribose) polymerase-1 activation during glutamate excitotoxicity. J Physiol 585:741-58. </div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>::::#Duan Y, Gross RA, Sheu SS (2007) Ca<sup>2+</sup>-dependent generation of mitochondrial reactive oxygen species serves as a signal for poly(ADP-ribose) polymerase-1 activation during glutamate excitotoxicity. J Physiol 585:741-58. </div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>::::#Pinto BB, Dyson A, Umbrello M, Carré JE, Ritter C, Clatworthy I, Duchen MR, Singer M (2017) Improved Survival in a long term-model of sepsis is associated with reduced mitochondrial calcium uptake despite increased energetic demand. Crit Care Med 45:e840-48</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>::::#Pinto BB, Dyson A, Umbrello M, Carré JE, Ritter C, Clatworthy I, Duchen MR, Singer M (2017) Improved Survival in a long term-model of sepsis is associated with reduced mitochondrial calcium uptake despite increased energetic demand. Crit Care Med 45:e840-48<ins style="font-weight: bold; text-decoration: none;">.</ins></div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>::::Financial support: NKFIH K116689, GINOP-2.3.2-15-2016-00034</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>::::Financial support: NKFIH K116689, GINOP-2.3.2-15-2016-00034</div></td></tr>
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Kandolf Georg
https://wiki.oroboros.at/index.php?title=Juhasz_2017_MiPschool_Obergurgl&diff=155709&oldid=prev
Kandolf Georg at 11:33, 28 March 2018
2018-03-28T11:33:01Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 11:33, 28 March 2018</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>::::#Singer M (2014) The role of mitochondrial dysfunction in sepsis-induced multi-organ failure. Virulence 5:66-72.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>::::#Singer M (2014) The role of mitochondrial dysfunction in sepsis-induced multi-organ failure. Virulence 5:66-72.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>::::#Duan Y, Gross RA, Sheu SS (2007) Ca<sup>2+</sup>-dependent generation of mitochondrial reactive oxygen species serves as a signal for poly(ADP-ribose) polymerase-1 activation during glutamate excitotoxicity. J Physiol 585:741-58. </div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>::::#Duan Y, Gross RA, Sheu SS (2007) Ca<sup>2+</sup>-dependent generation of mitochondrial reactive oxygen species serves as a signal for poly(ADP-ribose) polymerase-1 activation during glutamate excitotoxicity. J Physiol 585:741-58. </div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>::::#Pinto BB, Dyson A, Umbrello M, Carré JE, Ritter C, Clatworthy I, Duchen MR, Singer M (2017) Improved Survival in a long term-model of sepsis is associated with reduced mitochondrial calcium uptake despite increased energetic demand. Crit Care Med <del style="font-weight: bold; text-decoration: none;">[Epub ahead of print]</del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>::::#Pinto BB, Dyson A, Umbrello M, Carré JE, Ritter C, Clatworthy I, Duchen MR, Singer M (2017) Improved Survival in a long term-model of sepsis is associated with reduced mitochondrial calcium uptake despite increased energetic demand. Crit Care Med <ins style="font-weight: bold; text-decoration: none;">45:e840-48</ins></div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>::::Financial support: NKFIH K116689, GINOP-2.3.2-15-2016-00034</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>::::Financial support: NKFIH K116689, GINOP-2.3.2-15-2016-00034</div></td></tr>
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Kandolf Georg
https://wiki.oroboros.at/index.php?title=Juhasz_2017_MiPschool_Obergurgl&diff=149787&oldid=prev
Nirschl Lisa at 14:08, 12 January 2018
2018-01-12T14:08:22Z
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Abstract</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Abstract</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|title=[[File:Juhasz L.jpg|left|90px]] Blockade of N-methyl-D-aspartate receptors improves polymicrobial sepsis-evoked mitochondrial dysfunction in rats.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|title=[[File:Juhasz L.jpg|left|90px]] Blockade of N-methyl-D-aspartate receptors improves polymicrobial sepsis-evoked mitochondrial dysfunction in rats.</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>|info=[[<del style="font-weight: bold; text-decoration: none;">MITOEAGLE</del>]]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|info=[[<ins style="font-weight: bold; text-decoration: none;">MitoEAGLE</ins>]]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|authors=Juhasz L, Poles MZ, Tallosy SZP, Rutai A, Boros M, Vecsei L, Szabo A, Kaszaki J</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|authors=Juhasz L, Poles MZ, Tallosy SZP, Rutai A, Boros M, Vecsei L, Szabo A, Kaszaki J</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|year=2017</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|year=2017</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|event=MiPschool Obergurgl 2017</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|event=MiPschool Obergurgl 2017</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>|abstract=[[Image:MITOEAGLE-logo.jpg|left|100px|link=http://www.mitoglobal.org/index.php/MITOEAGLE|COST Action <del style="font-weight: bold; text-decoration: none;">MITOEAGLE</del>]]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|abstract=[[Image:MITOEAGLE-logo.jpg|left|100px|link=http://www.mitoglobal.org/index.php/MITOEAGLE|COST Action <ins style="font-weight: bold; text-decoration: none;">MitoEAGLE</ins>]]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Sepsis-related changes in oxygen dynamics and subsequent multi-organ failure are associated with mitochondrial dysfunction and depleted energy supplies [1]. Recently, N-methyl-D-aspartate receptor (NMDA-R)-mediated increase in intracellular calcium (Ca<sup>2+</sup>) level has been suggested as a major source for mitochondrial Ca<sup>2+</sup> uptake and Ca<sup>2+</sup> overload [2,3]. However, the relationship between NMDA-R–linked Ca<sup>2+</sup> entry and electron transport system function is still not fully elucidated. Thus, our main goal was to investigate whether NMDA-receptor antagonists, the natural kynurenic acid (KYNA) and its synthetic analogue, SZR-72 affects mitochondrial respiration in a rodent model of peritonitis-induced sepsis (PS).</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Sepsis-related changes in oxygen dynamics and subsequent multi-organ failure are associated with mitochondrial dysfunction and depleted energy supplies [1]. Recently, N-methyl-D-aspartate receptor (NMDA-R)-mediated increase in intracellular calcium (Ca<sup>2+</sup>) level has been suggested as a major source for mitochondrial Ca<sup>2+</sup> uptake and Ca<sup>2+</sup> overload [2,3]. However, the relationship between NMDA-R–linked Ca<sup>2+</sup> entry and electron transport system function is still not fully elucidated. Thus, our main goal was to investigate whether NMDA-receptor antagonists, the natural kynurenic acid (KYNA) and its synthetic analogue, SZR-72 affects mitochondrial respiration in a rodent model of peritonitis-induced sepsis (PS).</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
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Nirschl Lisa
https://wiki.oroboros.at/index.php?title=Juhasz_2017_MiPschool_Obergurgl&diff=139446&oldid=prev
Kandolf Georg at 06:46, 18 July 2017
2017-07-18T06:46:23Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 06:46, 18 July 2017</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Sepsis-related changes in oxygen dynamics and subsequent multi-organ failure are associated with mitochondrial dysfunction and depleted energy supplies [1]. Recently, N-methyl-D-aspartate receptor (NMDA-R)-mediated increase in intracellular calcium (Ca<sup>2+</sup>) level has been suggested as a major source for mitochondrial Ca<sup>2+</sup> uptake and Ca<sup>2+</sup> overload [2,3]. However, the relationship between NMDA-R–linked Ca<sup>2+</sup> entry and electron transport system function is still not fully elucidated. Thus, our main goal was to investigate whether NMDA-receptor antagonists, the natural kynurenic acid (KYNA) and its synthetic analogue, SZR-72 affects mitochondrial respiration in a rodent model of peritonitis-induced sepsis (PS).</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Sepsis-related changes in oxygen dynamics and subsequent multi-organ failure are associated with mitochondrial dysfunction and depleted energy supplies [1]. Recently, N-methyl-D-aspartate receptor (NMDA-R)-mediated increase in intracellular calcium (Ca<sup>2+</sup>) level has been suggested as a major source for mitochondrial Ca<sup>2+</sup> uptake and Ca<sup>2+</sup> overload [2,3]. However, the relationship between NMDA-R–linked Ca<sup>2+</sup> entry and electron transport system function is still not fully elucidated. Thus, our main goal was to investigate whether NMDA-receptor antagonists, the natural kynurenic acid (KYNA) and its synthetic analogue, SZR-72 affects mitochondrial respiration in a rodent model of peritonitis-induced sepsis (PS).</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>PS was induced in male Sprague Dawley rats by intraperitoneal injection of faeces (n=18, 0.6 g/kg body weight). Animals in control group were given saline only (C; n=6). NMDA-R was blocked by by either KYNA or SZR-72 (160 µmol/kg, ip. administered twice ip. 3h and 22 h after PS induction). Blood gases and haemodynamic parameters were monitored under anaesthesia and then animals were sacrificed for the assessment of cellular respiratory function. Mitochondrial Complex-I dependent (CI; glutamate/malate+ADP) and Complex-II dependent (CII; rotenone+succinate+ADP) mitochondrial oxygen consumption was assessed from liver homogenates using high-resolution respirometry (O2k, <del style="font-weight: bold; text-decoration: none;">OROBOROS </del>Instruments, Innsbruck, Austria). </div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>PS was induced in male Sprague Dawley rats by intraperitoneal injection of faeces (n=18, 0.6 g/kg body weight). Animals in control group were given saline only (C; n=6). NMDA-R was blocked by by either KYNA or SZR-72 (160 µmol/kg, ip. administered twice ip. 3h and 22 h after PS induction). Blood gases and haemodynamic parameters were monitored under anaesthesia and then animals were sacrificed for the assessment of cellular respiratory function. Mitochondrial Complex-I dependent (CI; glutamate/malate+ADP) and Complex-II dependent (CII; rotenone+succinate+ADP) mitochondrial oxygen consumption was assessed from liver homogenates using high-resolution respirometry (<ins style="font-weight: bold; text-decoration: none;">Oroboros </ins>O2k, <ins style="font-weight: bold; text-decoration: none;">Oroboros </ins>Instruments, Innsbruck, Austria). </div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>We found that glutamate/malate supported LEAK respiration and succinate supported LEAK respiration decreased markedly 24 h after the induction of PS. Similarly, both CI and CII-driven OXPHOS exhibited significantly lower values in septic rats, compared to sham-operated control animals (40% and 35%, respectively). However, the PS-induced decrease in CII-linked substrate oxidation and CII-linked OXPHOS capacity were markedly restored either by KYNA (72%) or SZR-72 (90%) while CI-linked mitochondrial respiratory function was only affected by SZR-72 administration. In addition, electron transport coupled to ATP synthesis evaluated by respiratory control ratio, observed to be higher in SZR-72 treated rats (RCR: 30%).</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>We found that glutamate/malate supported LEAK respiration and succinate supported LEAK respiration decreased markedly 24 h after the induction of PS. Similarly, both CI and CII-driven OXPHOS exhibited significantly lower values in septic rats, compared to sham-operated control animals (40% and 35%, respectively). However, the PS-induced decrease in CII-linked substrate oxidation and CII-linked OXPHOS capacity were markedly restored either by KYNA (72%) or SZR-72 (90%) while CI-linked mitochondrial respiratory function was only affected by SZR-72 administration. In addition, electron transport coupled to ATP synthesis evaluated by respiratory control ratio, observed to be higher in SZR-72 treated rats (RCR: 30%).</div></td></tr>
</table>
Kandolf Georg
https://wiki.oroboros.at/index.php?title=Juhasz_2017_MiPschool_Obergurgl&diff=138317&oldid=prev
Gnaiger Erich at 08:32, 7 July 2017
2017-07-07T08:32:31Z
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|instruments=Oxygraph-2k</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|instruments=Oxygraph-2k</div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Affiliations ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Affiliations ==</div></td></tr>
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Gnaiger Erich
https://wiki.oroboros.at/index.php?title=Juhasz_2017_MiPschool_Obergurgl&diff=138085&oldid=prev
Kandolf Georg at 12:42, 5 July 2017
2017-07-05T12:42:59Z
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>::::Financial support: NKFIH K116689, GINOP-2.3.2-15-2016-00034</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>::::Financial support: NKFIH K116689, GINOP-2.3.2-15-2016-00034</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"></del></div></td><td colspan="2"></td></tr>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"></del></div></td><td colspan="2"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"></del></div></td><td colspan="2"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">== Instructions ==</del></div></td><td colspan="2"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"></del></div></td><td colspan="2"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">::::* ''All details'': [[MiPschool_Obergurgl_2017#Abstracts |Abstracts]]</del></div></td><td colspan="2"></td></tr>
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Kandolf Georg
https://wiki.oroboros.at/index.php?title=Juhasz_2017_MiPschool_Obergurgl&diff=137537&oldid=prev
Kandolf Georg at 14:54, 21 June 2017
2017-06-21T14:54:32Z
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Abstract</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Abstract</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>|title=[[File:Juhasz L.jpg|left|90px]]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|title=[[File:Juhasz L.jpg|left|90px]] Blockade of N-methyl-D-aspartate receptors improves polymicrobial sepsis-evoked mitochondrial dysfunction in rats.</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Blockade of N-methyl-D-aspartate receptors improves polymicrobial sepsis-evoked mitochondrial dysfunction in rats.</div></td><td colspan="2"></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|info=[[MITOEAGLE]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|info=[[MITOEAGLE]]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|authors=Juhasz L, Poles MZ, Tallosy SZP, Rutai A, Boros M, Vecsei L, Szabo A, Kaszaki J</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|authors=Juhasz L, Poles MZ, Tallosy SZP, Rutai A, Boros M, Vecsei L, Szabo A, Kaszaki J</div></td></tr>
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Kandolf Georg
https://wiki.oroboros.at/index.php?title=Juhasz_2017_MiPschool_Obergurgl&diff=136799&oldid=prev
Beno Marija at 12:14, 12 June 2017
2017-06-12T12:14:43Z
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>|title=[[File:<del style="font-weight: bold; text-decoration: none;">MITOEAGLE-representation</del>.jpg|left|<del style="font-weight: bold; text-decoration: none;">60px|link=http://www.mitoglobal.org/index.php/MITOEAGLE|COST Action MITOEAGLE</del>]]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|title=[[File:<ins style="font-weight: bold; text-decoration: none;">Juhasz L</ins>.jpg|left|<ins style="font-weight: bold; text-decoration: none;">90px</ins>]]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Blockade of N-methyl-D-aspartate receptors improves polymicrobial sepsis-evoked mitochondrial dysfunction in rats.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Blockade of N-methyl-D-aspartate receptors improves polymicrobial sepsis-evoked mitochondrial dysfunction in rats.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|info=[[MITOEAGLE]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|info=[[MITOEAGLE]]</div></td></tr>
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Beno Marija
https://wiki.oroboros.at/index.php?title=Juhasz_2017_MiPschool_Obergurgl&diff=136788&oldid=prev
Kandolf Georg at 11:19, 12 June 2017
2017-06-12T11:19:02Z
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|event=MiPschool Obergurgl 2017</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|event=MiPschool Obergurgl 2017</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|abstract=[[Image:MITOEAGLE-logo.jpg|left|100px|link=http://www.mitoglobal.org/index.php/MITOEAGLE|COST Action MITOEAGLE]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|abstract=[[Image:MITOEAGLE-logo.jpg|left|100px|link=http://www.mitoglobal.org/index.php/MITOEAGLE|COST Action MITOEAGLE]]</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">At </del>the <del style="font-weight: bold; text-decoration: none;">request </del>of the <del style="font-weight: bold; text-decoration: none;">authors</del>, <del style="font-weight: bold; text-decoration: none;">this abstract is not made available online</del>.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Sepsis-related changes in oxygen dynamics and subsequent multi-organ failure are associated with mitochondrial dysfunction and depleted energy supplies [1]. Recently, N-methyl-D-aspartate receptor (NMDA-R)-mediated increase in intracellular calcium (Ca<sup>2+</sup>) level has been suggested as a major source for mitochondrial Ca<sup>2+</sup> uptake and Ca<sup>2+</sup> overload [2,3]. However, </ins>the <ins style="font-weight: bold; text-decoration: none;">relationship between NMDA-R–linked Ca<sup>2+</sup> entry and electron transport system function is still not fully elucidated. Thus, our main goal was to investigate whether NMDA-receptor antagonists, the natural kynurenic acid (KYNA) and its synthetic analogue, SZR-72 affects mitochondrial respiration in a rodent model </ins>of <ins style="font-weight: bold; text-decoration: none;">peritonitis-induced sepsis (PS).</ins></div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">PS was induced in male Sprague Dawley rats by intraperitoneal injection of faeces (n=18, 0.6 g/kg body weight). Animals in control group were given saline only (C; n=6). NMDA-R was blocked by by either KYNA or SZR-72 (160 µmol/kg, ip. administered twice ip. 3h and 22 h after PS induction). Blood gases and haemodynamic parameters were monitored under anaesthesia and then animals were sacrificed for </ins>the <ins style="font-weight: bold; text-decoration: none;">assessment of cellular respiratory function. Mitochondrial Complex-I dependent (CI; glutamate/malate+ADP) and Complex-II dependent (CII; rotenone+succinate+ADP) mitochondrial oxygen consumption was assessed from liver homogenates using high-resolution respirometry (O2k, OROBOROS Instruments, Innsbruck</ins>, <ins style="font-weight: bold; text-decoration: none;">Austria). </ins></div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">We found that glutamate/malate supported LEAK respiration and succinate supported LEAK respiration decreased markedly 24 h after the induction of PS. Similarly, both CI and CII-driven OXPHOS exhibited significantly lower values in septic rats, compared to sham-operated control animals (40% and 35%, respectively). However, the PS-induced decrease in CII-linked substrate oxidation and CII-linked OXPHOS capacity were markedly restored either by KYNA (72%) or SZR-72 (90%) while CI-linked mitochondrial respiratory function was only affected by SZR-72 administration. In addition, electron transport coupled to ATP synthesis evaluated by respiratory control ratio, observed to be higher in SZR-72 treated rats (RCR: 30%).</ins></div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Our hypothesis suggests that inhibition of NMDA receptors, perhaps through the regulation of intramitochondrial Ca<sup>2+</sup> pool and/or by attenuating the overproduction of reactive oxygen species, may modulate mitochondrial respiration and improve ADP utilisation to produce ATP</ins>.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|editor=[[Kandolf G]],</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|editor=[[Kandolf G]],</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|mipnetlab=HU Szeged Boros M</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|mipnetlab=HU Szeged Boros M</div></td></tr>
</table>
Kandolf Georg
https://wiki.oroboros.at/index.php?title=Juhasz_2017_MiPschool_Obergurgl&diff=136733&oldid=prev
Beno Marija at 06:44, 12 June 2017
2017-06-12T06:44:44Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 06:44, 12 June 2017</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l7">Line 7:</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|event=MiPschool Obergurgl 2017</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|event=MiPschool Obergurgl 2017</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|abstract=[[Image:MITOEAGLE-logo.jpg|left|100px|link=http://www.mitoglobal.org/index.php/MITOEAGLE|COST Action MITOEAGLE]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|abstract=[[Image:MITOEAGLE-logo.jpg|left|100px|link=http://www.mitoglobal.org/index.php/MITOEAGLE|COST Action MITOEAGLE]]</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">Sepsis-related changes in oxygen dynamics and subsequent multi-organ failure are associated with mitochondrial dysfunction and depleted energy supplies [1]. Recently, N-methyl-D-aspartate receptor (NMDA-R)-mediated increase in intracellular calcium (Ca<sup>2+</sup>) level has been suggested as a major source for mitochondrial Ca<sup>2+</sup> uptake and Ca<sup>2+</sup> overload [2,3]. However, </del>the <del style="font-weight: bold; text-decoration: none;">relationship between NMDA-R–linked Ca<sup>2+</sup> entry and electron transport system function is still not fully elucidated. Thus, our main goal was to investigate whether NMDA-receptor antagonists, the natural kynurenic acid (KYNA) and its synthetic analogue, SZR-72 affects mitochondrial respiration in a rodent model </del>of <del style="font-weight: bold; text-decoration: none;">peritonitis-induced sepsis (PS).</del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">At </ins>the <ins style="font-weight: bold; text-decoration: none;">request </ins>of the <ins style="font-weight: bold; text-decoration: none;">authors</ins>, <ins style="font-weight: bold; text-decoration: none;">this abstract is not made available online</ins>.</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td colspan="2"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">PS was induced in male Sprague Dawley rats by intraperitoneal injection of faeces (n=18, 0.6 g/kg body weight). Animals in control group were given saline only (C; n=6). NMDA-R was blocked by by either KYNA or SZR-72 (160 µmol/kg, ip. administered twice ip. 3h and 22 h after PS induction). Blood gases and haemodynamic parameters were monitored under anaesthesia and then animals were sacrificed for </del>the <del style="font-weight: bold; text-decoration: none;">assessment of cellular respiratory function. Mitochondrial Complex-I dependent (CI; glutamate/malate+ADP) and Complex-II dependent (CII; rotenone+succinate+ADP) mitochondrial oxygen consumption was assessed from liver homogenates using high-resolution respirometry (O2k</del>, <del style="font-weight: bold; text-decoration: none;">OROBOROS Instruments, Innsbruck, Austria). </del></div></td><td colspan="2"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td colspan="2"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">We found that glutamate/malate supported LEAK respiration and succinate supported LEAK respiration decreased markedly 24 h after the induction of PS. Similarly, both CI and CII-driven OXPHOS exhibited significantly lower values in septic rats, compared to sham-operated control animals (40% and 35%, respectively). However, the PS-induced decrease in CII-linked substrate oxidation and CII-linked OXPHOS capacity were markedly restored either by KYNA (72%) or SZR-72 (90%) while CI-linked mitochondrial respiratory function was only affected by SZR-72 administration. In addition, electron transport coupled to ATP synthesis evaluated by respiratory control ratio, observed to be higher in SZR-72 treated rats (RCR: 30%).</del></div></td><td colspan="2"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td colspan="2"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">Our hypothesis suggests that inhibition of NMDA receptors, perhaps through the regulation of intramitochondrial Ca<sup>2+</sup> pool and/or by attenuating the overproduction of reactive oxygen species, may modulate mitochondrial respiration and improve ADP utilisation to produce ATP</del>.</div></td><td colspan="2"></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|editor=[[Kandolf G]],</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|editor=[[Kandolf G]],</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|mipnetlab=HU Szeged Boros M</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|mipnetlab=HU Szeged Boros M</div></td></tr>
</table>
Beno Marija