Kampjut 2022 Curr Opin Struct Biol
Kampjut D, Sazanov LA (2022) Structure of respiratory complex I - An emerging blueprint for the mechanism. Curr Opin Struct Biol 74:102350. doi: 10.1016/j.sbi.2022.102350 |
Kampjut D, Sazanov Leonid A (2022) Curr Opin Struct Biol
Abstract: Complex I is one of the major respiratory complexes, conserved from bacteria to mammals. It oxidises NADH, reduces quinone and pumps protons across the membrane, thus playing a central role in the oxidative energy metabolism. In this review we discuss our current state of understanding the structure of complex I from various species of mammals, plants, fungi, and bacteria, as well as of several complex I-related proteins. By comparing the structural evidence from these systems in different redox states and data from mutagenesis and molecular simulations, we formulate the mechanisms of electron transfer and proton pumping and explain how they are conformationally and electrostatically coupled. Finally, we discuss the structural basis of the deactivation phenomenon in mammalian complex I.
β’ Bioblast editor: Gnaiger E
Labels: MiParea: Comparative MiP;environmental MiP
Enzyme: Complex I Regulation: Coupling efficiency;uncoupling