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Kayser 2023 MiP2023

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Kayser 2023 MiP2023

Kayser Bengt
Obesity and hypoxia: from etiology to therapy.

Link: MiP2023 Obergurgl AT

Kayser Bengt (2023)

Event: MiP2023 Obergurgl AT

The increased prevalence of obesity worldwide has sparked interest in the potential therapeutic use of hypoxia for managing the disease, because lifelong exposure to altitude lowers the risk of obesity, while altitude sojourns are associated with weight loss. Exposure to hypoxia can lead to a negative energy balance by reducing energy expenditure through changes in resting metabolic rate and physical activity energy expenditure and by reducing appetite. On the other hand, obesity is frequently linked to sleep disorders that cause intermittent systemic hypoxia, which can result in cardiovascular and metabolic issues. Hypoxic regions within hypertrophic white adipose tissue can lead to chronic inflammation, and obesity is also a risk factor for acute mountain sickness. Despite these negative effects, intermittent hypoxia exposure has been shown to be beneficial in some cases and the potential therapeutic benefits of hypobaric or normobaric hypoxic exposure in individuals with obesity to lower body mass and improve health status are being studied. Various protocols have been developed, including actual altitude sojourns and intermittent normobaric hypoxic exposures, either at rest or in combination with physical activity. Several studies have shown benefits on body mass and cardiovascular and metabolic variables, but more research is needed before systematically integrating hypoxic exposure as part of obesity management programs. Further studies are also required to clarify the effects of hypoxia on appetite, the intestinal microbiota, and overall energy balance.

  1. Kayser B, Verges S (2013) Hypoxia, energy balance and obesity: from pathophysiological mechanisms to new treatment strategies. https://doi.org/10.1111/obr.12034.
  2. Kayser B, Verges S. (2021) Hypoxia, energy balance, and obesity: An update. https://doi.org/10.1111/obr.13192.


โ€ข O2k-Network Lab: CH Lausanne Place N


Affiliations

Kayser Bengt1, Verges Samuel2
  1. Institute of sport sciences, University of Lausanne, Switzerland.
  2. Laboratoire HP2, INSERM, Universitรฉ Grenoble Alpes, France.
Author contributions: BK and SV contributed equally.
Conflict of interest: none.


Labels: Pathology: Obesity  Stress:Hypoxia 





Event: Oral