Larsen 2014 World J Diabetes: Difference between revisions
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{{Publication | {{Publication | ||
|title=Larsen S, Skaaby S, Helge JW, Dela F (2014) Effects of exercise training on mitochondrial function in patients with type 2 diabetes. World J Diabetes 5:482-92 | |title=Larsen S, Skaaby S, Helge JW, Dela F (2014) Effects of exercise training on mitochondrial function in patients with type 2 diabetes. World J Diabetes 5:482-92. | ||
|info=[http://www.ncbi.nlm.nih.gov/pubmed/25126394 PMID:25126394] | |info=[http://www.ncbi.nlm.nih.gov/pubmed/25126394 PMID:25126394] | ||
|authors=Larsen S, Skaaby S, Helge JW, Dela F | |authors=Larsen S, Skaaby S, Helge JW, Dela F | ||
|year=2014 | |year=2014 | ||
|journal=World J Diabetes | |journal=World J Diabetes | ||
|abstract=Type 2 diabetes is characterized by a decreased ability of insulin to facilitate glucose uptake into insulin sensitive tissue, i.e., skeletal muscle. The mechanism behind this is at the moment unresolved. It has been suggested that increased amount of lipids inside the skeletal muscle (intramuscular triglyceride, diacylglycerol and ceramides) will impair insulin action in skeletal muscle, but data are not consistent in the human literature. It has also been hypothesized that the impaired insulin sensitivity is due to a dysfunction in the mitochondria resulting in an impaired ability to oxidize lipids, but the majority of the literature is not supporting this hypothesis. Recently it has been suggested that the production of reactive oxygen species play an essential role in skeletal muscle insulin sensitivity. It is well accepted that physical activity (endurance, | |abstract=Type 2 diabetes is characterized by a decreased ability of insulin to facilitate glucose uptake into insulin sensitive tissue, i.e., skeletal muscle. The mechanism behind this is at the moment unresolved. It has been suggested that increased amount of lipids inside the skeletal muscle (intramuscular triglyceride, diacylglycerol and ceramides) will impair insulin action in skeletal muscle, but data are not consistent in the human literature. It has also been hypothesized that the impaired insulin sensitivity is due to a dysfunction in the mitochondria resulting in an impaired ability to oxidize lipids, but the majority of the literature is not supporting this hypothesis. Recently it has been suggested that the production of reactive oxygen species play an essential role in skeletal muscle insulin sensitivity. It is well accepted that physical activity (endurance, strength and high intensity training) improves insulin sensitivity in healthy humans and in patients with type 2 diabetes. Whether patients with type 2 diabetes have the same beneficial effects (same improvement) as control subjects, when it comes to regular physical activity in regard to mitochondrial function, is not established in the literature. This review will focus only on the effect of physical activity on skeletal muscle (mitochondrial function) in patients with type 2 diabetes. | ||
|keywords=Mitochondria, Exercise, Type 2 diabetes | |keywords=Mitochondria, Exercise, Type 2 diabetes | ||
|mipnetlab=DK Copenhagen Dela F | |mipnetlab=DK Copenhagen Dela F, DK Copenhagen Larsen S | ||
}} | }} | ||
{{Labeling | {{Labeling | ||
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|topics=Substrate | |topics=Substrate | ||
|couplingstates=OXPHOS | |couplingstates=OXPHOS | ||
| | |pathways=F | ||
|instruments=Oxygraph-2k | |instruments=Oxygraph-2k | ||
}} | }} |
Latest revision as of 15:46, 5 March 2019
Larsen S, Skaaby S, Helge JW, Dela F (2014) Effects of exercise training on mitochondrial function in patients with type 2 diabetes. World J Diabetes 5:482-92. |
Larsen S, Skaaby S, Helge JW, Dela F (2014) World J Diabetes
Abstract: Type 2 diabetes is characterized by a decreased ability of insulin to facilitate glucose uptake into insulin sensitive tissue, i.e., skeletal muscle. The mechanism behind this is at the moment unresolved. It has been suggested that increased amount of lipids inside the skeletal muscle (intramuscular triglyceride, diacylglycerol and ceramides) will impair insulin action in skeletal muscle, but data are not consistent in the human literature. It has also been hypothesized that the impaired insulin sensitivity is due to a dysfunction in the mitochondria resulting in an impaired ability to oxidize lipids, but the majority of the literature is not supporting this hypothesis. Recently it has been suggested that the production of reactive oxygen species play an essential role in skeletal muscle insulin sensitivity. It is well accepted that physical activity (endurance, strength and high intensity training) improves insulin sensitivity in healthy humans and in patients with type 2 diabetes. Whether patients with type 2 diabetes have the same beneficial effects (same improvement) as control subjects, when it comes to regular physical activity in regard to mitochondrial function, is not established in the literature. This review will focus only on the effect of physical activity on skeletal muscle (mitochondrial function) in patients with type 2 diabetes. โข Keywords: Mitochondria, Exercise, Type 2 diabetes
โข O2k-Network Lab: DK Copenhagen Dela F, DK Copenhagen Larsen S
Labels: MiParea: Respiration
Pathology: Diabetes
Organism: Human Tissue;cell: Skeletal muscle Preparation: Permeabilized tissue
Regulation: Substrate Coupling state: OXPHOS Pathway: F HRR: Oxygraph-2k