Cookies help us deliver our services. By using our services, you agree to our use of cookies. More information

Lemieux 2019b MiP2019

From Bioblast
Revision as of 12:22, 26 September 2019 by Plangger Mario (talk | contribs)
Hélène Lemieux
Altered mitochondrial metabolism in the diabetic heart.

Link: MiP2019

Makrecka-Kuka M, Liepinsh E, Murray AJ, Lemieux H, Dambrova M, Tepp K, Puurand M4 Kaambre T, Han WH, de Goede P, O’Brien KA, Turan B, Tuncay E, Olgar Y, Rolo AP, Palmeira CM, Boardman NT, Wuest RCI, Larsen TS (2019)

Event: MiP2019

COST Action MitoEAGLE

Obesity-induced insulin resistance and type 2 diabetes mellitus can ultimately result in various complications, including diabetic cardiomyopathy. In this case, cardiac dysfunction is characterized by metabolic disturbances such as impaired glucose oxidation and an increased reliance on fatty acid oxidation. Mitochondrial dysfunction has often been associated with the altered metabolic function in the diabetic heart, and may result from fatty acid-induced lipotoxicity and uncoupling of oxidative phosphorylation. In this review, we address the metabolic changes in the diabetic heart, focusing on the loss of metabolic flexibility and cardiac mitochondrial function. We consider the alterations observed in mitochondrial substrate utilization, bioenergetics and dynamics, and highlight new areas of research which may improve our understanding of the cause and effect of cardiac mitochondrial dysfunction in diabetes. Finally, we explore how lifestyle (nutrition and exercise) and pharmacological interventions can prevent and treat metabolic and mitochondrial dysfunction in diabetes.


Bioblast editor: Plangger M, Tindle-Solomon L O2k-Network Lab: CA Edmonton Lemieux H


Labels: Pathology: Diabetes 

Organism: Other invertebrates  Tissue;cell: Heart 





Affiliations

Makrecka-Kuka M(1), Liepinsh E(1), Murray AJ(2), Lemieux H(3), Dambrova M(1), Tepp K(4), Puurand M(4), Käämbre T(4), Han WH(5), de Goede P(6), O’Brien KA(2), Turan B(6), Tuncay E(7), Olgar Y(7), Rolo AP(8), Palmeira CM(8), Boardman NT(9), Wüst RCI(10), Larsen TS(9)
  1. Latvian Inst Organic Synthesis, Riga, Latvia
  2. Dept Physiology, Development Neuroscience, Univ Cambridge, UK
  3. Fac Saint-Jean, Women Children's Health Research Inst, Dept Medicine, Univ Alberta, Canada
  4. National Inst Chemical Physics Biophysics, Tallinn, Estonia
  5. Fac Saint-Jean Univ Alberta, Canada
  6. Lab Endocrinology, Amsterdam Univ Medical Center, Univ Amsterdam, Amsterdam Gastroenterology & Metabolism, Amsterdam, The Netherlands
  7. Dept Biophysics, Fac Medicine, Ankara Univ, Ankara, Turkey
  8. Department of Life Sciences, University of Coimbra and Center for Neurosciences and Cell Biology, University of Coimbra, Portugal
  9. Cardiovascular Research Group, Department of Medical Biology, UiT the Arctic University of Norway
  10. Laboratory for Myology, Faculty of Behavioural and Movement Sciences, Department of Human Movement Sciences, Amsterdam Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.