Difference between revisions of "Melatonin"
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|description='''Melatonin''' (N-acetyl-5-methoxytryptamine, aMT) is a highly conserved molecule present in unicellular to vertebrate organisms. Melatonin is synthesized from tryptophan in the pinealocytes by the pineal gland and also is produced in other organs, tissues and fluids (extrapineal melatonin). Melatonin has lipophilic and hydrophilic nature which allows it to cross biological membranes. Therefore, melatonin is present in all subcellular compartments predominantly in the nucleus and mitochondria. Melatonin has pleiotropic functions with powerful antioxidant, anti-inflammatory and oncostatic effects at the level of mitochondria. | |description='''Melatonin''' (N-acetyl-5-methoxytryptamine, aMT) is a highly conserved molecule present in unicellular to vertebrate organisms. Melatonin is synthesized from tryptophan in the pinealocytes by the pineal gland and also is produced in other organs, tissues and fluids (extrapineal melatonin). Melatonin has lipophilic and hydrophilic nature which allows it to cross biological membranes. Therefore, melatonin is present in all subcellular compartments predominantly in the nucleus and mitochondria. Melatonin has pleiotropic functions with powerful antioxidant, anti-inflammatory and oncostatic effects at the level of mitochondria. | ||
|info=Reiter 2003 Acta Biochim Pol | |info=[Reiter 2003 Acta Biochim Pol] [Acuña-Castroviejo 2014 Cell Mol Life Sci] | ||
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{{MitoPedia methods}} | {{MitoPedia methods}} | ||
Revision as of 17:42, 5 November 2014
- high-resolution terminology - matching measurements at high-resolution
Melatonin
Description
Melatonin (N-acetyl-5-methoxytryptamine, aMT) is a highly conserved molecule present in unicellular to vertebrate organisms. Melatonin is synthesized from tryptophan in the pinealocytes by the pineal gland and also is produced in other organs, tissues and fluids (extrapineal melatonin). Melatonin has lipophilic and hydrophilic nature which allows it to cross biological membranes. Therefore, melatonin is present in all subcellular compartments predominantly in the nucleus and mitochondria. Melatonin has pleiotropic functions with powerful antioxidant, anti-inflammatory and oncostatic effects at the level of mitochondria.
Abbreviation: aMT
Reference: [Reiter 2003 Acta Biochim Pol] [Acuña-Castroviejo 2014 Cell Mol Life Sci]
References
Acuña-Castroviejo et al (2014) Extrapineal melatonin: sources, regulation, and potential functions.
Reiter et al (2003) Melatonin as an antioxidant: biochemical mechanisms and pathophysiological implications in humans.
