MitoCom Events

2011-07-16: Manuscript for minor revision in IJBCB

• "Mitochondrial respiratory control and early defects of oxidative phosphorylation in the failing human heart" by Lemieux H, Semsroth S, Antretter H, Höfer D, Gnaiger E was reviewed for publication in Intl. J. Biochem. Cell Biol.
• From the referee's comments:
  • Reviewer #1: "The manuscript by Lemieux and colleagues offers interesting insight into the bioenergetics of early phases of heart failure."
  • Reviewer #2: "This is a beautifully written work, replete with well-designed experiments and, within the space limitations, a nice review of the pertinent literature. The demonstration of impaired mitochondrial fatty acid oxidation in early stages of human failure is very important, as is the demonstration of defects in the phosphorylation system and Complex I-linked respiration."
  • Reviewer #3: "The manuscript belongs literally to the symphony of bioenergetics and have mastered on a maximum thorough and detailed level a priority study of human heart disease bioenergetics in an intermediate state of heart disease, which was done only scarcely in medical sciences and for this orthodox approach this work deserves a high attention. It elegantly describes detailed oxidative phosphorylation parameters in heart disease compared to the control human heart. Using high-resolution respirometry of permeabilized human heart muscle fibres authors progressively describe distinct aspect of measured data in logical steps to present important differences of diminished mitochondrial function during heart failure. Using elegant protocols developed for years, authors distinguish between phosphorylating (OXPHOS) and non-phosphorylating (ETS) conditions with both complex I and II input using physiological substrates of glucose and lipid oxidation. With presented protocols, authors are able to provide conclusions regarding, e.g., complex I impairment, phosphorylation system limitation (3.2) mitochondrial content (3.3), leak respiration involvement, etc., besides OXPHOS and ETS capacities. Authors use their own terminology describing respiratory states. It would be useful to explain briefly their terminology also in terms of the canonical state 2 - 4 terminology. In spite of this, the methodology approach and presented data are well explained."

2011-07-13: The K-Regio MitoCom project application

• The MitoCom_K-Regio ''MitoCom Tyrol'' was accepted.

2011-07-13: Manuscript accepted in AJP

• "Similar qualitative and quantitative changes of mitochondrial respiration following strength and endurance training in normoxia and hypoxia in sedentary humans" by Pesta D, Hoppel F, Macek C, Messner H, Faulhaber M, Kobel C, Parson W, Burtscher M, Schocke M, Gnaiger E was accepted for publication in Am. J. Physiol. Regul. Integr. Comp. Physiol.
• From the referee's comments: This is really a superb revision; the MS has been improved substantially, particularly with reference to the theory and methods re: the HRR.

2011-07-11 to 13: Introductory O2k-Workshop (IOC62) - MitoCom Tyrol

• Location: OROBOROS INSTRUMENTS, Schöpfstr. 18, Innsbruck, Austria.
• For more informatio see: IOC62

2012-12-12 to 15: Crystals in Mitochondrial Competence

• Conference on Crystals in Mitochondrial Competence
• Location: Alpbach, Tyrol, Austria

MitoCom past events