MitoEAGLE

MitoGlobal first

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MitoEAGLE

Mitochondrial fitness mapping: Evolution - Age - Gender - Lifestyle - Environment

COST MITOEAGLE approved

From: COST Association [1]

Sent: 12 February 2016 17:16

To: [email protected]

Re: COST OC-2015-2-19984 Evaluation Feedback and YOUR ACTION REQUIRED

Dear Prof Erich Gnaiger,

We are happy to inform you that proposal OC-2015-2-19984 Mitochondrial mapping: Evolution - Age - Gender - Lifestyle - Environment was approved by the COST Committee of Senior Officials.

You can find the Evaluation report at: MITOEAGLE_COST-Evaluation2016-02-12.pdf.

Please note that in order to start your Action, its Memorandum of Understanding (MoU) needs to be finalised and published in our website and accepted by at least 5 COST Member Countries and the Cooperating State. The COST Association will publish the MoUs of Actions approved under this Collection on 26/02/2016. Your input for preparing the MoU is required by 19/02/2016 at the latest. Kindly ensure that all required fields are filled in by this date.

...

A Science Officer has been assigned for this Action. Should you require additional information, please do not hesitate to contact Dr Federica Ortelli at [email protected]

After preparing the MoU you may wish to contact your COST National Coordinator, Ms Nicole Schmidt ([email protected]) for your formal nomination to the Management Committee. You may now also inform your colleagues in the Network of Proposers and suggest them to contact their COST National Coordinators to further discuss their possible nomination to the Management Committee.

The contact details of all CNCs can be found at http://www.cost.eu/about_cost/who/%28type%29/3.

Please note that you have been allocated the e-COST role "Action Proposer". Please inform the Science Officer, should you not wish to accept this role.

Best regards,

COST Association

Avenue Louise 149

1050 Brussels | Belgium

[email protected]

www.cost.eu

Ref: S-4.B

COST Action proposal: MITOEAGLE

Summary

The objective of the MITOEAGLE network is to improve our knowledge on mitochondrial function in health and disease related to Evolution, Age, Gender, Lifestyle and Environment. Every study of mitochondrial (mt) function and disease is faced with EAGLE as the essential background conditions characterizing the individual patient, subject, study group, species, tissue or even cell line. To address the complex interrelationships of EAGLE with an initial focus on humans and rodent models, the network will enhance the value of each individual study by starting to analyse and catalog data beyond the published record. Highlighting the topic of mitochondrial function in relation to age, gender, lifstyle and environmental factors, unique new information will emerge on human biology from the development of a European reference database. Protocols, technologies and standard procedures will be compared and strategies defined for improvement of quality control. An interlaboratory proficiency ring test will be established as a world-wide innovation in the field of mitochondrial respiratory physiology. The expertise gained and new standards developed will be integrated into a strategic dissemination and education programme for mitochondrial phenotyping, aiming at an expanding European and MitoGlobal EAGLE network where researchers collaborate on mapping mitochondrial fitness in physiology and medicine, complementary to established mtDNA databases.

Further details » MitoEAGLE

Keywords

mitochondrial physiology, gender, aging, oxidative stress, life style, nutrition, sports, degenerative diseases, neurodegeneration, obesity, diabetes, cardiovascular diseases, cancer, latent mitochondrial dysfunction, stress resistance, respirometry, membrane potential, ROS production, redox regulation, isolated mitochondria, homogenate, cells, permeabilized cells, muscle fibres, tissues, model organisms

• MITOEAGLE aims at meeting current demands of the global research community to improve the data base on mitochondrial function/dysfunction in various tissues of humans and animal models, and to diagnose the mitochondrial implications in various pathologies, for development and evaluation of mitochondria-targeted therapies.
• MITOEAGLE opens the feedback loop between the primary problems of attack (gender-specific mitochondrial roles in fitness, aging, pathologies) and the consequential models and methods employed.
• MITOEAGLE will generate the critical mass of partners required to address the complex conceptual and methodological problems that may have prevented so far the major break-though required for addressing the preventable diseases in westernized ageing societies.
• MITOEAGLE is an initiative towards a broad but focussed project, to ‘contribute substantially to the coordination and defragmentation of research efforts across Europe’.

Information

Participants

A participant of a COST Action means any researcher, engineer or scholar who participates actively in a COST Action.

» List of participants

» MITOEAGLE circulars

Proposers

The main proposer of a COST Action means the coordinator of the network of proposers who submit a proposal for a COST Action in response to the open call. MITOEAGLE is an initiative of MitoFit. If you are interested to participate in the MITOEAGLE network, please contact:

Erich Gnaiger, Ao.Univ.-Prof., Ph.D.

Medical University of Innsbruck

Department of Visceral, Transplant and Thoracic Surgery

D. Swarovski Research Laboratory

A-6020 Innsbruck, Austria

Email: [email protected]

Link: MitoFit

Disclosure: Dr Erich Gnaiger is founder and CEO of OROBOROS INSTRUMENTS – www.oroboros.at

COST timetable

• Submitted: 2015-09-08
• Approved: 2016-02-12

COST website

» Website COST Actions

» Current COST Actions in Biomedicine and Molecular Biosciences

COST member states

» COST member states

Austria, Belgium, Bosnia and Herzegovina, Bulgaria, Croatia, Cyprus, Czech Republic, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Iceland, Ireland, Italy, Latvia, Lithuania, Luxembourg, Malta, The Netherlands, Norway, Poland, Portugal, Romania, Serbia, Slovakia, Slovenia, Spain, Sweden, Switzerland, Turkey, United Kingdom and the former Yugoslav Republic of Macedonia.

COST member states in bold are represented in the COST MITOEAGLE consortium.

• COST cooperating state: Israel.
• The Management Committee (MC) may include up to two representatives from Near Neighbor Countries or International Partner Countries as MC Observers. MC Observers have no voting rights.

Egypt and the USA are representated in the COST MITOEAGLE consortium