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Difference between revisions of "MitoEAGLE"

From Bioblast
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{{MitoGlobal header page name}}
{{MitoGlobal header page name}}
:::: <big><big><big>Mitochondrial mapping: '''E'''</big>volution - <big>'''A'''</big>ge - <big>'''G'''</big>ender - <big>'''L'''</big>ifestyle - <big>'''E'''</big>nvironment</big></big>
:::: <big><big><big>Mitochondrial fitness mapping: '''E'''</big>volution - <big>'''A'''</big>ge - <big>'''G'''</big>ender - <big>'''L'''</big>ifestyle - <big>'''E'''</big>nvironment</big></big>




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=== Summary ===
=== Summary ===
The objective of the '''MITO<big>EAGLE</big>''' network is to improve our knowledge on mitochondrial function in health and disease related to '''<big>E</big>'''volution, '''<big>A</big>'''ge, '''<big>G</big>'''ender, '''<big>L</big>'''ifestyle and '''<big>E</big>'''nvironment. Every study of mitochondrial (mt) function and disease is faced with EAGLE as the essential background conditions characterizing the individual patient, subject, study group, species, tissue or even cell line. To address the complex interrelationships of EAGLE with an initial focus on humans and rodent models, the network will enhance the value of each individual study by starting to analyse and catalog data beyond the published record. Highlighting the topic of gender and mitochondrial function, unique new information will emerge on human biology from the development of a European reference database. Protocols, technologies and standard procedures will be compared and strategies defined for improvement of quality control. An inter-laboratory ring test will be established as a world-wide innovation in the field of mitochondrial respiratory physiology. The expertise gained and new standards developed will be integrated into a strategic dissemination and education programme for mitochondrial phenotyping, aiming at an expanding European and MitoGlobal EAGLE network where researchers collaborate on mapping mitochondrial physiology and medicine, complementary to established mtDNA databases.
The objective of the '''MITO<big>EAGLE</big>''' network is to improve our knowledge on mitochondrial function in health and disease related to '''<big>E</big>'''volution, '''<big>A</big>'''ge, '''<big>G</big>'''ender, '''<big>L</big>'''ifestyle and '''<big>E</big>'''nvironment. Every study of mitochondrial (mt) function and disease is faced with EAGLE as the essential background conditions characterizing the individual patient, subject, study group, species, tissue or even cell line. To address the complex interrelationships of EAGLE with an initial focus on humans and rodent models, the network will enhance the value of each individual study by starting to analyse and catalog data beyond the published record. Highlighting the topic of mitochondrial function in relation to age, gender, lifstyle and environmental factors, unique new information will emerge on human biology from the development of a European reference database. Protocols, technologies and standard procedures will be compared and strategies defined for improvement of quality control. An interlaboratory proficiency ring test will be established as a world-wide innovation in the field of mitochondrial respiratory physiology. The expertise gained and new standards developed will be integrated into a strategic dissemination and education programme for mitochondrial phenotyping, aiming at an expanding European and MitoGlobal EAGLE network where researchers collaborate on mapping mitochondrial fitness in physiology and medicine, complementary to established mtDNA databases.
: ''Further details'' » '''[[MitoGlobal EAGLE]]'''
: ''Further details'' » '''[[MitoGlobal EAGLE]]'''
=== Objective ===
Mitochondria play multiple roles in health and degenerative diseases. To understand these roles better is a current need in the European research, medical and commercial communities, particularly to implement protective and preventive measures optimized according to age, gender, lifestyle (nutrition, sport), and environment. In addition, results on humans and comparison with animal models requires evaluation of the evolutionary background beyond the scope of each individual study or research group. Therefore, the MITOEAGLE network aims at mapping data on mitochondrial function as a basis of better understanding the complex background of EAGLE. Strategies will be implemented to improve standardized methods for evaluating and scoring acute and latent mitochondrial dysfunction, at baseline and in response pathological stress. As a result, interventions (nutrition, exercise, drugs, novel treatments) that potentially impact on mitochondrial health, can be evaluated objectively in different labs and health-care institutions. By coordinating a critical mass of expertise, the network will address the problems that may have prevented so far the major break-though required for relating the quality of life and the severity of disease to a clinically standardized measure of mitochondrial function – providing vital knowledge to improve health.
Traditional lifestyles of ‘remote’ human populations are dwindling, such that these highly significant windows into our evolutionary past are about to becoming closed, forever. While studies of mitochondrial DNA (mtDNA) have become firmly established in the search for the evolutionary history and diversification of the human species, mitochondrial function remains largely unexplored, but may turn out to provide key information for preventing diseases which become epidemic in developing countries, and which become prevalent upon transition to a Westernized lifestyle. Ethnic-specific mitochondrial fitness in human populations is hardly accessible by todays regular approach of research, with few exceptional scientific expeditions providing examples of the difficulties involved. The experience gained by the cooperation of an enlarging scientific network will set the stage to extend the screening of mitochondrial fitness to a large variety of ethnic groups, such that the complete spectrum of EAGLE will be incorporated into an expanding MitoGlobal data base. MITOEAGLE will develop the standards required to make this possible. The project will include animal models used in research on aging and diseases. Future projects will extend the concept to gain invaluable information on comparative mitochondrial physiology by the study of a wide range of organisms, including endangered species.


=== Working groups (WG) ===
=== Working groups (WG) ===


'''WG1.     MITOEAGLE data base on gender and mt-function in health and disease'''
'''WG1. MITOEAGLE data repository on mt-fitness in human muscle tissue in health and disease'''
:* Mainly published data from WG participants will be cataloged in the detail beyond the published record (anonymised data on individuals in addition to group averages; tabulated results in addition to figures; conversion to common SI units; comparability of normalization).
 
'''WG2. MITOEAGLE data repository on mt-fitness in human blood cells in health and disease'''
 
'''WG3. MITOEAGLE data repository on mt-fitness in rodent tissues and cells in health and disease'''
 
'''WG4. MITOEAGLE data repository on mt-fitness in response to protection, disease, and therapies'''
 
:* In the MITOEAGLE data respositories mainly published data from WG participants will be cataloged in the detail beyond the published record (anonymised data on individuals in addition to group averages; tabulated results in addition to figures; conversion to common SI units; comparability of normalization).
:* Data management systems - diversity vs. unification to manage the MITOEAGLE biometrics database.
:* Data management systems - diversity vs. unification to manage the MITOEAGLE biometrics database.
:* Measures of mitochondrial respiratory function in human and rodent tissues, blood cells and cell lines will be structured according to the EAGLE background, with specific emphasis on gender-specific mt-function and gender medicine; joint publication.
:* Measures of mitochondrial respiratory function in human and rodent tissues, blood cells and cell lines will be structured according to the EAGLE background, with specific emphasis on aging, gender-specific mt-function and gender medicine, lifestyle and environmental factors; joint publication.


'''WG2.     Challenges on quality control for reference data in mitochondrial physiology'''
'''WG5. Challenges on quality control for reference data in mitochondrial physiology'''
:* Basic concepts and communication: Consolidation of concepts and nomenclature on mitochondrial respiratory states and control parameters; [[MitoPedia]]; joint publication.
:* Basic concepts and communication: Consolidation of concepts and nomenclature on mitochondrial respiratory states and control parameters; [[MitoPedia]]; joint publication.
:* Laboratory standards: Protocols, technologies and standard procedures; data base on laboratory protocols.
:* Laboratory standards: Protocols, technologies and standard procedures; data base on laboratory protocols.
:* Reference data in mitochondrial physiology: Quality control, documentation, bioinformatics standards.  
:* Reference data in mitochondrial physiology: Quality control, documentation, bioinformatics standards.  


'''WG3.     Inter-laboratory test and outreach'''
'''WG6. Interlaboratory proficiency test'''
:* An inter-laboratory ring test will be introduced in practice as a world-wide innovation in the field of mitochondrial respiratory physiology: design and implementation; reference sample dissemination; test protocol(s); data analysis; joint publication.
:* An inter-laboratory ring test will be introduced in practice as a world-wide innovation in the field of mitochondrial respiratory physiology: design and implementation; reference sample dissemination; test protocol(s); data analysis; joint publication.
:* Comparison of results between and within instrumental platforms.
:* Comparison of results between and within instrumental platforms.
:* Logistics for extended future collaboration in Europe, North and South America, Asia, Australia and Africa.
:* Logistics for extended future collaboration in Europe, North and South America, Asia, Australia and Africa.


'''WG4.     Training and data sharing'''
'''WG4. Recommendations, training and data management'''
:* Recommendations for quality control, data reporting and data sharing beyond the published record.
:* Recommendations for quality control, data reporting and data sharing beyond the published record.
:* Concepts on Open Access and institutionalized service for data management, data mining and health-care conforming standards of data interpretation.
:* Concepts on Open Access and institutionalized service for data management, data mining and health-care conforming standards of data interpretation.
:* Summary on strategic dissemination and education programme for MitoGlobal EAGLE.
:* Summary on strategic dissemination and education programme for MitoGlobal EAGLE.
=== Objective ===
Mitochondria play multiple roles in health and degenerative diseases. To understand these roles better is a current need in the European research, medical and commercial communities, particularly to implement protective and preventive measures optimized according to age, gender, lifestyle (nutrition, sport), and environment. In addition, results on humans and comparison with animal models requires evaluation of the evolutionary background beyond the scope of each individual study or research group. Therefore, the MITOEAGLE network aims at mapping data on mitochondrial function as a basis of better understanding the complex background of EAGLE. Strategies will be implemented to improve standardized methods for evaluating and scoring acute and latent mitochondrial dysfunction, at baseline and in response pathological stress. As a result, interventions (nutrition, exercise, drugs, novel treatments) that potentially impact on mitochondrial health, can be evaluated objectively in different labs and health-care institutions. By coordinating a critical mass of expertise, the network will address the problems that may have prevented so far the major break-though required for relating the quality of life and the severity of disease to a clinically standardized measure of mitochondrial function – providing vital knowledge to improve health.




=== Keywords ===
=== Keywords ===
mitochondrial physiology, gender, aging, oxidative stress, life style, nutrition, sports, degenerative diseases, neurodegeneration, obesity, diabetes, cardiovascular diseases, cancer, latent mitochondrial dysfunction, stress resistance, respirometry, membrane potential, ROS production, redox regulation, isolated mitochondria, homogenate, cells, permeabilized cells, muscle fibres, tissues, model organisms
mitochondrial physiology, gender, aging, oxidative stress, life style, nutrition, sports, degenerative diseases, neurodegeneration, obesity, diabetes, cardiovascular diseases, cancer, latent mitochondrial dysfunction, stress resistance, respirometry, membrane potential, ROS production, redox regulation, isolated mitochondria, homogenate, cells, permeabilized cells, muscle fibres, tissues, model organisms


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=== COST timetable===
=== COST timetable===
Submission deadline: 2015-03-24
* Submission: Oct 2015 (spring submission deadline would be 2015-03-24)
 
Final decision: 2015-10





Revision as of 09:34, 19 March 2015


MitoGlobal         MitoGlobal Societies         MiPsociety         Asia Society for Mitochondrial Research and Medicine         MitoGlobal Events         MitoGlobal first



MitoEAGLE

Mitochondrial fitness mapping: Evolution - Age - Gender - Lifestyle - Environment


COST Action proposal: MITOEAGLE

Summary

The objective of the MITOEAGLE network is to improve our knowledge on mitochondrial function in health and disease related to Evolution, Age, Gender, Lifestyle and Environment. Every study of mitochondrial (mt) function and disease is faced with EAGLE as the essential background conditions characterizing the individual patient, subject, study group, species, tissue or even cell line. To address the complex interrelationships of EAGLE with an initial focus on humans and rodent models, the network will enhance the value of each individual study by starting to analyse and catalog data beyond the published record. Highlighting the topic of mitochondrial function in relation to age, gender, lifstyle and environmental factors, unique new information will emerge on human biology from the development of a European reference database. Protocols, technologies and standard procedures will be compared and strategies defined for improvement of quality control. An interlaboratory proficiency ring test will be established as a world-wide innovation in the field of mitochondrial respiratory physiology. The expertise gained and new standards developed will be integrated into a strategic dissemination and education programme for mitochondrial phenotyping, aiming at an expanding European and MitoGlobal EAGLE network where researchers collaborate on mapping mitochondrial fitness in physiology and medicine, complementary to established mtDNA databases.

Further details » MitoGlobal EAGLE

Objective

Mitochondria play multiple roles in health and degenerative diseases. To understand these roles better is a current need in the European research, medical and commercial communities, particularly to implement protective and preventive measures optimized according to age, gender, lifestyle (nutrition, sport), and environment. In addition, results on humans and comparison with animal models requires evaluation of the evolutionary background beyond the scope of each individual study or research group. Therefore, the MITOEAGLE network aims at mapping data on mitochondrial function as a basis of better understanding the complex background of EAGLE. Strategies will be implemented to improve standardized methods for evaluating and scoring acute and latent mitochondrial dysfunction, at baseline and in response pathological stress. As a result, interventions (nutrition, exercise, drugs, novel treatments) that potentially impact on mitochondrial health, can be evaluated objectively in different labs and health-care institutions. By coordinating a critical mass of expertise, the network will address the problems that may have prevented so far the major break-though required for relating the quality of life and the severity of disease to a clinically standardized measure of mitochondrial function – providing vital knowledge to improve health.

Traditional lifestyles of ‘remote’ human populations are dwindling, such that these highly significant windows into our evolutionary past are about to becoming closed, forever. While studies of mitochondrial DNA (mtDNA) have become firmly established in the search for the evolutionary history and diversification of the human species, mitochondrial function remains largely unexplored, but may turn out to provide key information for preventing diseases which become epidemic in developing countries, and which become prevalent upon transition to a Westernized lifestyle. Ethnic-specific mitochondrial fitness in human populations is hardly accessible by todays regular approach of research, with few exceptional scientific expeditions providing examples of the difficulties involved. The experience gained by the cooperation of an enlarging scientific network will set the stage to extend the screening of mitochondrial fitness to a large variety of ethnic groups, such that the complete spectrum of EAGLE will be incorporated into an expanding MitoGlobal data base. MITOEAGLE will develop the standards required to make this possible. The project will include animal models used in research on aging and diseases. Future projects will extend the concept to gain invaluable information on comparative mitochondrial physiology by the study of a wide range of organisms, including endangered species.


Working groups (WG)

WG1. MITOEAGLE data repository on mt-fitness in human muscle tissue in health and disease

WG2. MITOEAGLE data repository on mt-fitness in human blood cells in health and disease

WG3. MITOEAGLE data repository on mt-fitness in rodent tissues and cells in health and disease

WG4. MITOEAGLE data repository on mt-fitness in response to protection, disease, and therapies

  • In the MITOEAGLE data respositories mainly published data from WG participants will be cataloged in the detail beyond the published record (anonymised data on individuals in addition to group averages; tabulated results in addition to figures; conversion to common SI units; comparability of normalization).
  • Data management systems - diversity vs. unification to manage the MITOEAGLE biometrics database.
  • Measures of mitochondrial respiratory function in human and rodent tissues, blood cells and cell lines will be structured according to the EAGLE background, with specific emphasis on aging, gender-specific mt-function and gender medicine, lifestyle and environmental factors; joint publication.

WG5. Challenges on quality control for reference data in mitochondrial physiology

  • Basic concepts and communication: Consolidation of concepts and nomenclature on mitochondrial respiratory states and control parameters; MitoPedia; joint publication.
  • Laboratory standards: Protocols, technologies and standard procedures; data base on laboratory protocols.
  • Reference data in mitochondrial physiology: Quality control, documentation, bioinformatics standards.

WG6. Interlaboratory proficiency test

  • An inter-laboratory ring test will be introduced in practice as a world-wide innovation in the field of mitochondrial respiratory physiology: design and implementation; reference sample dissemination; test protocol(s); data analysis; joint publication.
  • Comparison of results between and within instrumental platforms.
  • Logistics for extended future collaboration in Europe, North and South America, Asia, Australia and Africa.

WG4. Recommendations, training and data management

  • Recommendations for quality control, data reporting and data sharing beyond the published record.
  • Concepts on Open Access and institutionalized service for data management, data mining and health-care conforming standards of data interpretation.
  • Summary on strategic dissemination and education programme for MitoGlobal EAGLE.


Keywords

mitochondrial physiology, gender, aging, oxidative stress, life style, nutrition, sports, degenerative diseases, neurodegeneration, obesity, diabetes, cardiovascular diseases, cancer, latent mitochondrial dysfunction, stress resistance, respirometry, membrane potential, ROS production, redox regulation, isolated mitochondria, homogenate, cells, permeabilized cells, muscle fibres, tissues, model organisms

  • MITOEAGLE aims at meeting current demands of the global research community to improve the data base on mitochondrial function/dysfunction in various tissues of humans and animal models, and to diagnose the mitochondrial implications in various pathologies, for development and evaluation of mitochondria-targeted therapies.
  • MITOEAGLE opens the feedback loop between the primary problems of attack (gender-specific mitochondrial roles in fitness, aging, pathologies) and the consequential models and methods employed.
  • MITOEAGLE will generate the critical mass of partners required to address the complex conceptual and methodological problems that may have prevented so far the major break-though required for addressing the preventable diseases in westernized ageing societies.
  • MITOEAGLE is an initiative towards a broad but focussed project, to ‘contribute substantially to the coordination and defragmentation of research efforts across Europe’.


Information

Participants

A participant of a COST Action means any researcher, engineer or scholar who participates actively in a COST Action.

» List of participants
» MITOEAGLE circulars

Proposers

The main proposer of a COST Action means the coordinator of the network of proposers who submit a proposal for a COST Action in response to the open call. MITOEAGLE is an initiative of MitoCom. If you are interested to participate in the MITOEAGLE network, please contact:

Erich Gnaiger, Ao.Univ.-Prof., Ph.D.
Medical University of Innsbruck
Department of Visceral, Transplant and Thoracic Surgery
D. Swarovski Research Laboratory
A-6020 Innsbruck, Austria
Email: [email protected]
Link: MitoCom Tyrol
Disclosure: Dr Erich Gnaiger is founder and CEO of OROBOROS INSTRUMENTS – www.oroboros.at


COST timetable

  • Submission: Oct 2015 (spring submission deadline would be 2015-03-24)


COST website

» Website COST Actions
» Current COST Actions in Biomedicine and Molecular Biosciences


COST member states

» 35 member states:
Austria, Belgium, Bosnia and Herzegovina, Bulgaria, Croatia, Cyprus, Czech Republic, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Iceland, Ireland, Italy, Latvia, Lithuania, Luxembourg, Malta, The Netherlands, Norway, Poland, Portugal, Romania, Serbia, Slovakia, Slovenia, Spain, Sweden, Switzerland, Turkey, United Kingdom and the former Yugoslav Republic of Macedonia.