Difference between revisions of "MitoKIN"
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== MitoKIN: FFG BRIDGE 1 == | == MitoKIN: FFG BRIDGE 1 == | ||
::::* FFG BRIDGE 1 30. Call - Project No. 877163, University of Innsbruck, Institute of Biochemistry | ::::* FFG BRIDGE 1 30. Call - Project No. 877163, University of Innsbruck, Institute of Biochemistry | ||
::::* '''Duration''': 36 months | ::::* '''Duration''': 36 months extended additional 12 months | ||
::::* '''Start''': 2020-02-03 | ::::* '''Start''': 2020-02-03 | ||
[[File:MitoKIN O2ks.jpg|right|400px|thumb|Dr. Eduard Stefan and Dr. Omar Torres-Quesada receiving the O2k instruments for the MitoKIN project.]] | |||
== About MitoKIN == | |||
:::: Led by the Institute of Biochemistry at the University of Innsbruck, the MitoKIN project aims to connect specific/broad kinase activities to precise metabolic functions (mitochondria) relevant for cell proliferation or survival. Applied inhibitors could then be used to barcode involved kinase pathways that change the metabolome by boosting or preventing mitochondrial functions. | :::: Led by the Institute of Biochemistry at the University of Innsbruck, the MitoKIN project aims to connect specific/broad kinase activities to precise metabolic functions (mitochondria) relevant for cell proliferation or survival. Applied inhibitors could then be used to barcode involved kinase pathways that change the metabolome by boosting or preventing mitochondrial functions. | ||
=== Aims === | === Aims === | ||
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== Coordinator == | == Coordinator == | ||
::::* [[Stefan E| Eduard Stefan, Ph.D.]] - Institute of Biochemistry, University of Innsbruck - https://www.uibk.ac.at/biochemistry/people/stefan/ | ::::* [[Stefan E| Eduard Stefan, Ph.D.]] - Institute of Biochemistry, University of Innsbruck - https://www.uibk.ac.at/biochemistry/people/stefan/ | ||
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[[File:MitoKIN group photo.jpg|right|400px|thumb|Back row, left to right: Eduard, Verana, Carolina, Erich; front row left to right: Lisa, Omar]] | [[File:MitoKIN group photo.jpg|right|400px|thumb|Back row, left to right: Eduard, Verana, Carolina, Erich; front row left to right: Lisa, Omar]] | ||
=== Participants === | === Participants === | ||
::::'''Institute of Biochemistry, University of Innsbruck''' | ::::'''Institute of Biochemistry, University of Innsbruck''' | ||
::::* [[Stefan E| '''Eduard Stefan, Ph.D.''']] - Project Coordinator, WP 1 & 4 Leader | ::::* [[Stefan E| '''Eduard Stefan, Ph.D.''']] - Project Coordinator, WP 1 & 4 Leader | ||
::::* [[Torres-Quesada O| '''Omar Torres-Quesada, Ph.D.''']] - Project Coordinator, WP 2-4 Leader | ::::* [[Torres-Quesada O| '''Omar Torres-Quesada, Ph.D.''']] - Project Coordinator, WP 2-4 Leader | ||
:::: '''Oroboros Instruments GmbH''' - www.oroboros.at | :::: '''Oroboros Instruments GmbH''' - [https://www.oroboros.at/ www.oroboros.at] | ||
::::* [[Gnaiger E| '''Erich Gnaiger, Ph.D.''']] - PI | ::::* [[Gnaiger E| '''Erich Gnaiger, Ph.D.''']] - PI | ||
::::* [[ | ::::* [[Schmitt Sabine| '''Sabine Schmitt, Ph.D.''']] - WP 2 Leader | ||
::::* [[Laner V| '''Verena Laner''']] - Oroboros project management | ::::* [[Laner V| '''Verena Laner''']] - Oroboros project management | ||
::::* [[Tindle-Solomon L| '''Lisa Tindle-Solomon''']] - Oroboros project management | ::::* [[Tindle-Solomon L| '''Lisa Tindle-Solomon''']] - Oroboros project management | ||
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:::: Oroboros Instruments will provide both infrastructure and the expertise required to conduct the respirometric measurements of the project. | :::: Oroboros Instruments will provide both infrastructure and the expertise required to conduct the respirometric measurements of the project. | ||
:::: The Institute of Biochemistry has been equipped with 3 O2ks for the duration of the project. | |||
== MitoKIN | == MitoKIN publications, preprints, abstracts and events == | ||
{{#ask:[[Category:Publications]] [[Additional label::MitoKIN]] | {{#ask:[[Category:Publications]] [[Additional label::MitoKIN]] | ||
|?Was published in year=When | |?Was published in year=When | ||
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== Links == | == Links == | ||
:::: | |||
'''News and articles''' | |||
:::: [https://www.ffg.at/news/successstory-kincon-laesst-medikamenten-forschung-aufleuchten #SuccessStory: KinCon lässt Medikamenten-Forschung aufleuchten] www.ffg.at, 2022-08-08 | |||
:::: [https://www.uibk.ac.at/newsroom/krebs-kinasen-und-zellkraftwerke.html.de Krebs, Kinasen und Zellkraftwerke] www.uibk.ac.at, 2020-02-04 | |||
== Support == | == Support == | ||
This project has received funding from the Austrian Reserach Promotion Funding Agency (FFG). [[File:FFG-logo.png|left|100px]] | This project has received funding from the Austrian Reserach Promotion Funding Agency (FFG). [[File:FFG-logo.png|left|100px]] |
Latest revision as of 18:56, 1 December 2022
MitoKIN
MitoKIN - Systematic barcoding of kinase-controlled mitochondrial function
MitoKIN: FFG BRIDGE 1
- FFG BRIDGE 1 30. Call - Project No. 877163, University of Innsbruck, Institute of Biochemistry
- Duration: 36 months extended additional 12 months
- Start: 2020-02-03
About MitoKIN
- Led by the Institute of Biochemistry at the University of Innsbruck, the MitoKIN project aims to connect specific/broad kinase activities to precise metabolic functions (mitochondria) relevant for cell proliferation or survival. Applied inhibitors could then be used to barcode involved kinase pathways that change the metabolome by boosting or preventing mitochondrial functions.
Aims
- The MitoKIN project has three major aims:
- 1. Impact of specific/general kinase inhibition on metabolism & mitochondrial function.
- 2. Perturbation of PKA signaling in cancer cells (high cAMP levels).
- 3. Perturbation of PKA signaling in neurodegenerative disease models (low cAMP levels).
Coordinator
- Eduard Stefan, Ph.D. - Institute of Biochemistry, University of Innsbruck - https://www.uibk.ac.at/biochemistry/people/stefan/
Network
Participants
- Institute of Biochemistry, University of Innsbruck
- Eduard Stefan, Ph.D. - Project Coordinator, WP 1 & 4 Leader
- Omar Torres-Quesada, Ph.D. - Project Coordinator, WP 2-4 Leader
- Institute of Biochemistry, University of Innsbruck
- Oroboros Instruments GmbH - www.oroboros.at
- Erich Gnaiger, Ph.D. - PI
- Sabine Schmitt, Ph.D. - WP 2 Leader
- Verena Laner - Oroboros project management
- Lisa Tindle-Solomon - Oroboros project management
- Oroboros Instruments GmbH - www.oroboros.at
Oroboros project involvement
- Oroboros Instruments will provide both infrastructure and the expertise required to conduct the respirometric measurements of the project.
- The Institute of Biochemistry has been equipped with 3 O2ks for the duration of the project.
MitoKIN publications, preprints, abstracts and events
When | Where | |
---|---|---|
MiPNet25.06 IOC145 Innsbruck AT | 2020-01-27 | Innsbruck AT, 2020 Jan 27-29. O2k-Coaching Days - Basic IOC145. |
Torres-Quesada 2022 BEC | 2022 | Torres-Quesada O, Strich S, Stefan E (2022) Kinase perturbations redirect mitochondrial function in cancer. Bioenerg Commun 2022.13. https://doi.org/10.26124/bec:2022-0013 |
Torres-Quesada 2022 MitoFit | 2022 | Torres-Quesada O, Doerrier C, Strich S, Gnaiger E, Stefan E (2022) Human Plasma-Like Media fine-tune mitochondrial function and alter drug sensitivity in cancer cell lines. https://doi.org/10.26124/mitofit:2022-0008 — 2022-08-13 published in https://doi.org/10.3390/cancers14163917 |
Torres-Quesada 2022 MitoFit Kinase | 2022 | Torres-Quesada O, Strich S, Stefan E (2022) Kinase perturbations redirect mitochondrial function. https://doi.org/10.26124/mitofit:2022-0011 — 2022-11-15 published in Bioenerg Commun 2022.13. |
Torres-Quesada 2022 Cancers (Basel) | 2022 | Torres-Quesada O, Doerrier C, Strich S, Gnaiger E, Stefan E (2022) Physiological cell culture media tune mitochondrial bioenergetics and drug sensitivity in cancer cell models. https://doi.org/10.3390/cancers14163917 |
Links
News and articles
- #SuccessStory: KinCon lässt Medikamenten-Forschung aufleuchten www.ffg.at, 2022-08-08
- Krebs, Kinasen und Zellkraftwerke www.uibk.ac.at, 2020-02-04
Support
This project has received funding from the Austrian Reserach Promotion Funding Agency (FFG).