MitoKit-CII: Difference between revisions
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== Compounds of MitoKit-CII == | == Compounds of MitoKit-CII == | ||
:::: The MitoKit-CII consists of the first generation of NeuroVive Pharmaceutical AB's cell permeable succinate and malonate prodrugs. It was developed to stimulate (succinate) or inhibit (malonate) the Complex II of the respiratory electron transfer system in | :::: The MitoKit-CII consists of the first generation of NeuroVive Pharmaceutical AB's cell permeable succinate and malonate prodrugs. It was developed to stimulate (succinate) or inhibit (malonate) the Complex II of the respiratory electron transfer system in living cells, and will expand the toolbox for evaluating the role of mitochondria in disease. | ||
:::: The MitoKit-CII is composed of the following compounds: | :::: The MitoKit-CII is composed of the following compounds: |
Revision as of 14:19, 29 May 2019
MitoKit-CII
Description | Cell permeable compound - MitoKit-CII, 2 vials; 1 vial of plasma membrane-permeable succinate (NV118; 25 mg) and 1 vial of plasma membrane-permeable malonate (NV161; 10 mg). |
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Product ID | 60200-01 |
Type | O2k |
Link | MitoKit-CII MitoPedia |
Image |
Compounds of MitoKit-CII
- The MitoKit-CII consists of the first generation of NeuroVive Pharmaceutical AB's cell permeable succinate and malonate prodrugs. It was developed to stimulate (succinate) or inhibit (malonate) the Complex II of the respiratory electron transfer system in living cells, and will expand the toolbox for evaluating the role of mitochondria in disease.
- The MitoKit-CII is composed of the following compounds:
- Cell permeable compound NV118/MitoKit-CII
- Description: Succinate prodrug: C10H14O8, Molecular weight 262.2 g.mol-1
- Aliquots of 25 mg
- Cell permeable compound NV161/MitoKit-CII
- Description: Malonate prodrug: C9H12O8, Molecular weight 248.2 g.mol-1
- Aliquots of 10 mg
- Reference
- Ehinger JK, Piel S, Ford R, Karlsson M, SjΓΆvall F, Frostner EΓ , Morota S, Taylor RW, Turnbull DM, Cornell C, Moss SJ, Metzsch C, Hansson MJ, Fliri H, ElmΓ©r E (2016) Cell-permeable succinate prodrugs bypass mitochondrial Complex I deficiency. Nat Commun 7:12317. Β»Bioblast linkΒ« - Original publication introducing Mito-CII.
Expiry date of MitoKit-CII compounds (according to NeuroVive)
- Before preparation
- 3 years in -80Β° C
- 1 year in -20Β° C
- Before preparation
- Prepared
- In DMSO solution
- at room temperature: 24 h
- at -20 Β°C: for 6 months
- Prepared
- CAS-Numbers
- NV118/MitoKit-CII: 1592635-33-0
- NV161/MitoKit-CII: 1432752-62-9
- CAS-Numbers
Labels: MiParea: Instruments;methods
HRR: O2k-Protocol
O2k-chemicals and media