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Difference between revisions of "Mitophagy"

From Bioblast
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Autophagy (self-eating) in general is viewed as a degradation process which removes non-essential or damaged cellular constituents. ’’’Mitophagy’’’, which is specifically targeted to mitochondria, eliminates dysfunctional or damaged mitochondria. During the course of life, mitochondrial genomes accumulate mutations that impair respiration and can lead to excessive [[ROS]]. ROS is also a well-known side product of normal [[respiration]] and can damage other organelles. By eliminating damaged or dysfunctional components of the cell and the mitochondrion, mitophagy is an important mechanism in the cellular adaptation to stress and serves as a quality-control ensuring proper mitochondrial and cell function. Β 
Autophagy (self-eating) in general is viewed as a degradation process which removes non-essential or damaged cellular constituents. '''Mitophagy''', which is specifically targeted to mitochondria, eliminates dysfunctional or damaged mitochondria. During the course of life, mitochondrial genomes accumulate mutations that impair respiration and can lead to excessive [[ROS]]. ROS is also a well-known side product of normal [[respiration]] and can damage other organelles. By eliminating damaged or dysfunctional components of the cell and the mitochondrion, mitophagy is an important mechanism in the cellular adaptation to stress and serves as a quality-control ensuring proper mitochondrial and cell function. Β 


'''Mechanism'''
'''Mechanism'''


Autophagy, or in mitochondrial terms, mitophagy occurs by the formation of autophagosomes. These essentially double-membraned vesicles sequester damaged organelles, proteins, or portions of the cytoplasm, which then fuse with lysosomes. After being fused, the sequestered contents are degraded by the acidic environment of lysosomal enzymes. In order to accomplish this task, more than 30 Atg (AuTophaGy-related) proteins are recruited.
Autophagy, or in mitochondrial terms, mitophagy occurs by the formation of autophagosomes. These essentially double-membraned vesicles sequester damaged organelles, proteins, or portions of the cytoplasm, which then fuse with lysosomes. After being fused, the sequestered contents are degraded by the acidic environment of lysosomal enzymes. In order to accomplish this task, more than 30 Atg (AuTophaGy-related) proteins are recruited.

Revision as of 15:46, 20 May 2012


high-resolution terminology - matching measurements at high-resolution


Mitophagy

Description

Abbreviation: Mitophagy

Reference: Mitochondria and the autophagy-inflammation-cell death axis in organismal aging. Science, 2011, 333, 1109-1112


MitoPedia methods: Respirometry, Fluorometry 



Autophagy (self-eating) in general is viewed as a degradation process which removes non-essential or damaged cellular constituents. Mitophagy, which is specifically targeted to mitochondria, eliminates dysfunctional or damaged mitochondria. During the course of life, mitochondrial genomes accumulate mutations that impair respiration and can lead to excessive ROS. ROS is also a well-known side product of normal respiration and can damage other organelles. By eliminating damaged or dysfunctional components of the cell and the mitochondrion, mitophagy is an important mechanism in the cellular adaptation to stress and serves as a quality-control ensuring proper mitochondrial and cell function.

Mechanism

Autophagy, or in mitochondrial terms, mitophagy occurs by the formation of autophagosomes. These essentially double-membraned vesicles sequester damaged organelles, proteins, or portions of the cytoplasm, which then fuse with lysosomes. After being fused, the sequestered contents are degraded by the acidic environment of lysosomal enzymes. In order to accomplish this task, more than 30 Atg (AuTophaGy-related) proteins are recruited.