Difference between revisions of "Nuclear receptors"
| Line 1: | Line 1: | ||
{{MitoPedia | {{MitoPedia | ||
|abbr= | |abbr=NRs | ||
|description=Nuclear receptors are ligand-dependent transcription factors. | |description=Nuclear receptors are ligand-dependent transcription factors. | ||
|info=[http://www.ncbi.nlm.nih.gov/pubmed/22284354 Burris_2012_Chem Biol]; | |||
}} | }} | ||
{{MitoPedia methods}} | {{MitoPedia methods}} | ||
Revision as of 16:35, 28 May 2012
- high-resolution terminology - matching measurements at high-resolution
Nuclear receptors
Description
Nuclear receptors are ligand-dependent transcription factors.
Abbreviation: NRs
Reference: Burris_2012_Chem Biol;
In contrast to extracellular receptors such as the insulin receptor, intracellular receptors directely bind endocrine hormones and dietary lipids. Nuclear receptors interact directly with lipophilic ligands and bind to specific DNA response elements to regulate expression of target genes. All nuclear receptor members have a similar canonical domain structure that includes an N-terminal activation domain and conserved DNA and ligand-binding domains. Well known members of the nuclear-receptor superfamily include the three different ligand-activated peroxisome proliverator activated receptor (PPAR) subtypes, PPAR-Ξ±, PPAR-Ξ²/Ξ΄, and PPAR-Ξ³ or the retinoid X receptor (RXR).
